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Possible treatment for kidney disease in lupus studied at UH
Date:5/4/2014

ules and selected this inhibitor, which seems to be working in clinical trails with other renal diseases. Additionally, the safety of the inhibitor has already been established, so if his team's experiments go well, he thinks the transition to clinical trials would come quickly.

"To put it in perspective, lupus affects so many pathways and cells. So, if we are successful, this would be one of many different ways of attacking such a complex disease," Mohan said. "We do believe this drug would be more efficacious than the currently available steroids, which essentially dampen the entire immune system."

Mohan, who is a Hugh Roy and Lillie Cranz Cullen Endowed Professor of biomedical engineering in the Cullen College of Engineering, focuses on the genetics of systemic lupus erythematosus (often simply called SLE or lupus). A major goal of his lab is trying to detect who would develop lupus or other chronic rheumatic autoimmune diseases, such as arthritis, and whether individuals will go on to develop kidney, lung, joint, skin or brain diseases, which are all common complications of SLE.


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Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

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