Navigation Links
Possible treatment for kidney disease in lupus studied at UH
Date:5/4/2014

developing kidney disease once they've developed lupus."

Specifically, Mohan is referring to a pathogenic cascade found in inflammatory kidney diseases, which includes three molecules kallikreins, bradykinin and one of two bradykinin receptors. High levels of these three specific molecules work together to cause the disease.

The kallikrein enzyme leads to the production of bradykinin, which is a peptide that helps regulate blood pressure and inflammation. The kidneys also have elevated levels of the two bradykinin receptors (B1 and B2), which are proteins that chemically bond with bradykinin to set certain biological processes in motion. While the B2 receptor plays a role in disease protection, the B1 receptor induces inflammation and fibrosis in the kidneys, eventually leading to kidney failure. In lupus patients, B1 is more prevalent. The goal of the ALR grant is to determine whether this pathway can be blocked, thus preventing the activation of certain receptors in the kidneys.

Mohan and his research team, including research assistant professor Yong Du, are working with a drug already in clinical trials for other kidney diseases. This drug acts as an inhibitor that attaches to B1 and physically blocks it from bonding with bradykinin. No bond means no kidney inflammation. Mohan's group will study how subjects with lupus nephritis respond to this inhibitor drug.

"We will compare the efficacy of this novel therapy with that of steroids, which is currently the most common standard of care, in suppressing lupus nephritis," Mohan said. "If these subjects show significant improvement, we will have established the link between lupus nephritis and the pathogenic cascade we are targeting, as well as show that the inhibitor is an excellent candidate for treating lupus nephritis."

Mohan believes there is a high chance this will work, since the company that developed the drug has already gone through many libraries of molec
'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. University of Houston study shows BP oil spill hurt marshes, but recovery possible
2. Researcher who identifed genetic cause and possible treatment for Marfan syndrome honored
3. New York University scientists discover possible treatment to reduce scarring
4. UCLA research makes possible rapid assessment of plant drought tolerance
5. Selfish DNA in animal mitochondria offers possible tool to study aging
6. Is long-term weight loss possible after menopause?
7. African research identifies strong candidate for possible single-dose malaria cure
8. Controlling gait of horses may be possible, says key study from Texas A&M
9. Weber State Scientists discover possible building blocks of ancient genetic systems
10. Estrogenic plants linked to altered hormones, possible behavior changes in monkeys
11. Possible new treatment for Ewing sarcoma
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Possible treatment for kidney disease in lupus studied at UH
(Date:4/14/2015)... April 14, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... the 2015 New York Design Awards under the category  ... York City Design Awards are part of a global ... 2,500 ratings from the marketplace, industry and judging panel. ...
(Date:4/13/2015)... -- higi, a leading cloud-based consumer engagement platform that provides ... their communities around health and wellness, announced today the ... ... convenient vehicle to receive validated health information from consumers. ... API will allow higi,s trusted partners, on a user ...
(Date:4/9/2015)... SAN JOSE, Calif. , April 9, 2015 /PRNewswire/ ... of human interface solutions, announced today that it will ... 2015 on Thursday, April 23, 2015, after the close ... call for analysts and investors at 2:00 p.m. PT ... information.    To participate on the live ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2
... parasites, roads as weed highways, and chemical warfare between alien and ... covered in NeoBiota a new open-access, peer-reviewed, ... by Pensoft Publishers continuing the former NeoBiota ... Ingolf Khn from the Helmholtz Centre for Environmental Research ...
... NYU Langone Medical Center,s Departments of Orthopaedic Surgery and ... to detect subtle changes in joint cartilage microstructure ... markers of early osteoarthritis (OA). By using these techniques ... shift the management of the disease from eventual joint ...
... of Toronto, The Hospital for Sick Children (SickKids), St. ... identified a new treatment target for a virus that ... common colds. The virus, called human respiratory syncytial virus ... of infants and children under two years of age; ...
Cached Biology News:Open minded and open access: NeoBiota, a new publishing platform for invasion biologists 2Open minded and open access: NeoBiota, a new publishing platform for invasion biologists 3NYU Langone experts find MRI techniques can detect early osteoarthritis 2Researchers map pathway of infection for a common, potentially life-threatening respiratory virus 2
(Date:4/27/2015)... y HEIDELBERG , Alemania, April ... obtiene la patente para un nuevo receptor utilizando tecnología ... una necesidad no cubierta en el tratamiento de millones ... Molecular Health ha anunciado hoy que ha recibido una patente ... patente apoya el descubrimiento de Molecular Health de que ...
(Date:4/27/2015)... April 27, 2015 Dr. Robert Hanzlik, ... chemical toxicity carries implications for advancing the creation of ... at National University , the second-largest private, nonprofit ... Dr. Hanzlik, a professor at the University of Kansas ... drug design, starts at 5 p.m. and takes place ...
(Date:4/27/2015)... , April 27, 2015  Edico Genome today ... geneticists from Harvard and Stanford Universities showed the ... genome sequence with 300x depth of coverage by ... to 60 hours with standard software. ... challenge, especially for individual research and clinical labs, ...
(Date:4/27/2015)... April 27, 2015 Deadly viruses such ... newest resident of the University City Science Center's ... Philadelphia. , With a $4.5 million Phase 2 ... hand, Phelix Therapeutics is focused on therapies ... supplements. The company is developing first-in-class protease inhibitors based ...
Breaking Biology Technology:Molecular Health obtiene la patente para un nuevo receptor 2Molecular Health obtiene la patente para un nuevo receptor 3Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 2Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 3Edico Genome, in Collaboration with Researchers from Harvard and Stanford Universities, Speeds Analysis of Whole Genome Sequence with 300x Depth of Coverage Tenfold 2Edico Genome, in Collaboration with Researchers from Harvard and Stanford Universities, Speeds Analysis of Whole Genome Sequence with 300x Depth of Coverage Tenfold 3New Resident of Science Center’s Port Business Incubator Targets SARS and Ebola 2
... PRINCETON, N.J., July 7 Medarex, Inc.,(Nasdaq: MEDX ... to,listen to a live webcast of its 2008 R&D ... 2008 at 8:00 a.m. Eastern Time and is expected ... will,provide an overview of the company,s strategy, progress and ...
... 7 The winners of the Ferring Research,Infertility ... the,European Society for Human Reproduction & Embryology Congress. ... University Medical Centre Utrecht, The,Netherlands and the Universitair ... winning research institutions were selected for their outstanding,proposals ...
... 7, 2008 Senomyx, Inc.,(Nasdaq: SNMX ), ... discover and develop novel flavor ingredients for the ... one-year extension of its,exclusive collaborative research and license ... Cadbury plc, for the discovery and commercialization of,new ...
Cached Biology Technology:Medarex Announces July 10 Live Webcast of R&D Day Event 2Ferring Research Infertility and Gynaecology GrAnt (FRIGGA) 2008 Winners Announced 2Ferring Research Infertility and Gynaecology GrAnt (FRIGGA) 2008 Winners Announced 3SENOMYX ANNOUNCES EXTENSION OF DISCOVERY AND DEVELOPMENT COLLABORATION WITH CADBURY PLC 2SENOMYX ANNOUNCES EXTENSION OF DISCOVERY AND DEVELOPMENT COLLABORATION WITH CADBURY PLC 3
Request Info...
... service provides the premium quality siRNAs you ... siRNAs can be readily ordered online by ... or by providing the sense and antisense ... Validated and Silencer Pre-designed siRNAs, which are ...
Ready for formulation or direct injection into animals Provided in convenient 100, 250, 1000 and 10,000 nmol sizes HPLC purified, salt free, sterile filtered, and endotoxin tested ...
GEL FILTRATION CAL KIT HMW, 1 EA. *Category: Gel Filtration Gels....
Biology Products: