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Possible new treatment for Ewing sarcoma
Date:11/26/2012

roperties in several different cancers, including acute leukemias, breast and prostate cancers," Sharma said.

"After Steve showed that LSD-1 was directly regulating the function of EWS/FLI, we teamed up with him to see whether the LSD inhibitors we had discovered worked in Ewing sarcoma models," Sharma said. "Our tests in Ewing sarcoma tissue cultures show they are extremely potent."

Lessnick and Sharma are now working together to further test LSD inhibitors in animal models as they work toward approval of a first-in-man clinical trial. In addition, Lessnick's basic science research on LSD-1 in Ewing sarcoma continues. "We think it may play a larger role in Ewing sarcoma than simply turning off a handful of genes, and we're looking into that," said Lessnick.

"This is a great example of how collaboration between the therapeutics and basic science programs can lead to new treatments for patientsone of HCI's highest goals," said Sharma.


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Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

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