Navigation Links
Possible new treatment for Ewing sarcoma
Date:11/26/2012

SALT LAKE CITY Discovery of a new drug with high potential to treat Ewing sarcoma, an often deadly cancer of children and young adults, and the previously unknown mechanism behind it, come hand-in-hand in a new study by researchers from Huntsman Cancer Institute (HCI) at the University of Utah. The report appears in today's online issue of the journal Oncogene.

"Ewing sarcoma is almost always caused by a cancer-causing protein called EWS/FLI," said Stephen Lessnick, M.D., Ph.D., director of HCI's Center for Children's Cancer Research, professor in the Department of Pediatrics at the University of Utah School of Medicine, and an HCI investigator.

In the lab, Lessnick and his colleagues found that an enzyme, called lysine specific demethylase (LSD-1), interacts with EWS/FLI to turn off gene expression in Ewing sarcoma. By turning off specific genes, the EWS/FLI-LSD1 complex causes Ewing sarcoma development. "This makes LSD-1 an important target for the development of new drugs to treat Ewing sarcoma," Lessnick said.

"For a long time, we've known that EWS/FLI works by binding to DNA and turning on genes that activate cancer formation," said Lessnick. "It was a surprise to find out that it turns genes off as well.

"The beauty, if there's anything beautiful about a nasty disease like this, is that if we can inhibit EWS/FLI, we can inhibit this cancer, because EWS/FLI is the master regulator of Ewing sarcoma," Lessnick added.

While Lessnick and his colleagues worked on EWS/FLI in their basic science lab, Sunil Sharma, M.D., director of HCI's Center for Investigational Therapeutics, professor in the Department of Medicine at the University of Utah, and an HCI investigator, had already focused on LSD-1 as a possible target for new cancer treatments and had been working for several years to design drugs that would inhibit its actions.

"We had found that LSD-1 was important for regulation of a variety of p
'/>"/>

Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Houston study shows BP oil spill hurt marshes, but recovery possible
2. Researcher who identifed genetic cause and possible treatment for Marfan syndrome honored
3. New York University scientists discover possible treatment to reduce scarring
4. UCLA research makes possible rapid assessment of plant drought tolerance
5. Selfish DNA in animal mitochondria offers possible tool to study aging
6. Is long-term weight loss possible after menopause?
7. African research identifies strong candidate for possible single-dose malaria cure
8. Controlling gait of horses may be possible, says key study from Texas A&M
9. Weber State Scientists discover possible building blocks of ancient genetic systems
10. Estrogenic plants linked to altered hormones, possible behavior changes in monkeys
11. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... an EC-FP5 four-year project, delivering its first release in ... participations in several EC projects, as a part of ... (EU BON), to increase the general awareness of the ... general dissemination of the Fauna Europaea results, the ... novel e-Publishing tools to prepare data papers for all ...
(Date:9/17/2014)... plastic shopping bags and their environmental impact recently scored ... first statewide ban on the bags, and Governor Jerry ... bag industry is not yielding without a fight, according ... , the weekly newsmagazine of the American Chemical Society. ... that the anti-bag campaign logged its first small victory ...
(Date:9/17/2014)... have obtained the first partial genome sequence of an ... at the site of the Montsoriu Castle in Girona, ... closely related to today,s Iberian pig. Researchers also discard ... Iberian pigs. , The study, published in Heredity ... species, and particularly on that of the Iberian breed, ...
Breaking Biology News(10 mins):Contributions on Fauna Europaea: Data papers as innovative model on expert involvement 2Iberian pig genome remains unchanged after 5 centuries 2
... press release is available in German . ... at the Max Planck Institute for Developmental Biology in ... to identify neuronal correlates of behaviour by comparing maps ... different behaviour. They compared the pharyngeal nervous systems of ...
... had been in the business of trading wetlands rather than ... current guidelines for wetland restoration. Research from the University of ... over wetland restoration sites result in more environmentally positive outcomes. ... under the current policies if a wetland is scheduled for ...
... in The Journal of General Physiology ... results, indicating that the extracellular accumulation of potassium that ... thought. Muscle excitation involves the influx of sodium ... of ions that cross the muscle membrane with each ...
Cached Biology News:The neurobiological consequence of predating or grazing 2The neurobiological consequence of predating or grazing 3Trading wetlands no longer a deal with the devil 2Trading wetlands no longer a deal with the devil 3Study offers new insights into the mechanics of muscle fatigue 2
(Date:9/18/2014)... , Sept. 18, 2014  U.S. biotech company ... signing an exclusive license for technology developed by the ... gene expression in plants, including for applications in production ... The technology was developed under the direction ... at Kultevat and former president of the Danforth Plant ...
(Date:9/18/2014)... Oncothyreon Inc. (NASDAQ: ONTY ) today announced ... offerings of 10,000,000 shares of its Common Stock at ... for expected gross proceeds of $20 million and 10,000 ... a price to the public of $2,000.00 per share, ... of Series A Convertible Preferred Stock is non-voting and ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 OMICS ... the globe to participate in the ‘Open Access ... articles to OMICS Group Pharma Journals ... one of the fastest emerging Sciences, accelerating with ... healthcare services across the globe. The industry is ...
(Date:9/18/2014)... a research lab can be pretty expensive. Now a ... has published an open-source library of designs that will ... piece of equipment: the syringe pump. , Syringe pumps ... for drug delivery or mixing chemicals in a reaction. ... dollars. , Joshua Pearce and his team of Michigan ...
Breaking Biology Technology:Kultevat obtains license of gene switch technology 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3Doing science just got cheaper -- and faster 2
... Pioneering medical device company Signostics announced today ... Food and Drug Administration (FDA) for its ... http://www.newscom.com/cgi-bin/prnh/20090519/SF19276 )Signostics has developed a cost-effective device ... affordable for individual health professionals to use ...
... Inc. (TSX:SBS), specializing in the manufacture of high-value ... encouraging data from the Company,s Apo AI(Milano) development ... SemBioSys, plant-derived Apo AI(Milano) has exhibited the appropriate ... plaque volume. , New data from two of ...
... NANJING, China, May 19 /PRNewswire-Asia/ -- Simcere Pharmaceutical Group,(NYSE: ... of branded generic and,innovative anti-cancer pharmaceuticals in China, announced ... Officer. , Dr. Wang will ... and,innovative research projects. He will also participate in ...
Cached Biology Technology:Signostics Receives FDA Clearance for World's Smallest Ultrasound Product 2SemBioSys' plant-derived Apo AI(Milano) demonstrates encouraging biologic activity in seven preclinical models 2SemBioSys' plant-derived Apo AI(Milano) demonstrates encouraging biologic activity in seven preclinical models 3SemBioSys' plant-derived Apo AI(Milano) demonstrates encouraging biologic activity in seven preclinical models 4Simcere Pharmaceutical Group Appoints Dr. Peng Wang as Chief Scientific Officer 2
Sheep polyclonal to ErbB 2 ( Abpromise for all tested applications). Antigen: Recombinant full length c-ErbB2 protein (Human). Entrez GeneID: 2064 Swiss Protein ID: P04626...
... OA-Hy cis- 9-Octadecenoyl-N-hydroxylamide Oleoyl-N-hydroxylamide ... INERT GAS. A potent inhibitor of MMP-2 ... i = 1.7 μM). Purity: ... or DMSO. Unstable in solution, reconstitute just ...
MAb to Vasopressin Preservative: NaN3...
Rabbit Anti-Human Secretory Carrier Membrane Protein 2 (SCAMP2 Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: Western Blot...
Biology Products: