Navigation Links
Possible hepatitis C vaccine
Date:9/5/2007

Hepatitis C Virus (HCV) infects up to 500,000 people in the UK alone, many of the infections going undiagnosed. It is the single biggest cause of people requiring a liver transplant in Britain. Now, in a collaborative effort with groups across Europe and the USA, scientists from The University of Nottingham have found monoclonal antibodies which may be a significant step towards a vaccine.

Hepatitis C treatment is expensive and not successful in all patients. Untreated or unresponsive patients can go on to develop cirrhosis of the liver, with life affecting consequences or the need for a liver transplant.

Dr Alexander Tarr, a Research Fellow at the Institute of Infection, Immunity and Inflammation presented a paper Human antibodies to Hepatitis C virus potential for vaccine design at the Society for General Microbiologys 161st meeting which is being held at The University of Edinburgh this week.

The group has recently analysed antibodies that can successfully prevent infection with many diverse strains of Hepatitis C virus in laboratory models. Dr Tarr said: The clinical potential of this work cannot be overstated. Historically, successful vaccines against viruses have required the production of antibodies, and this is likely to be the case for Hepatitis C virus. Identifying regions of the virus that are able to induce broadly reactive neutralising antibodies is a significant milestone in the development of a HCV vaccine, which will have distinct healthcare benefits for hepatitis sufferers, and could also help us design vaccines for other chronic viral diseases such as HIV.

Hepatitis C virus infects 180 million people worldwide. Infection with the virus can lead to liver cancer, and is the most common reason for liver transplantation in both the UK and the USA.

We are also currently exploring the possibility of improving liver transplantation success rates by passively infusing people with these antibodies said Dr Tarr. We are also using the information gained by identifying and characterising the antibody responses to Hepatitis C virus to design new ways of making vaccine candidates. If the antibodies we have discovered can be reproduced by vaccination, control of the disease might be possible.


'/>"/>

Contact: Dr. Alexander Tarr
alex.tarr@nottingham.ac.uk
University of Nottingham
Source:Eurekalert

Related biology news :

1. Viral DNA sequence a possible trigger for breast cancer
2. New studies suggest airborne SARS transmission is possible
3. New method shows it is possible to grow bone for grafts within a patients body
4. Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors
5. Possible treatment found for chemobrain
6. Protein amplification in melanoma is possible drug target
7. Is it Possible to Change Prescribing Habits?
8. From one cell, many possible cures
9. Group proves its possible to grow new lung alveoli by growing new blood vessels
10. Oh, rats! Designer animals reveal possible heart disease genes
11. Team discovers possible universal strategy to combat addiction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2016)... , Jan. 22, 2016 ... the addition of the "Global Biometrics ... to their offering. --> ... the "Global Biometrics Market in Retail ... --> Research and Markets ...
(Date:1/18/2016)... , Jan. 18, 2016  Extenua Inc., ... that simplifies the use and access of ubiquitous ... go-to-market partnership with American Cyber.  ... extensive experience leading transformational C4ISR and Cyber initiatives ... integrating the latest proven technology solutions," said ...
(Date:1/11/2016)... , Jan. 11, 2016  higi, the ... nearly 10,000 retail locations, web and mobile, today ... $40 million from existing investors. ... be devoted to further innovate higi,s health platform ... and web portal – including expanding services and ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... Sinovac Biotech Ltd. ("Sinovac" or the "Company") (NASDAQ: ... China , today announced that the ... February 4, 2016 a preliminary non-binding proposal letter, dated ... V-Ming ( Shanghai ) Investment Holdings Co., ... Shenzhen ) Fund Management Co., Ltd., Beijing ...
(Date:2/4/2016)... ... February 04, 2016 , ... Many of the engineers ... 10 years. What sets them apart from other cuvette manufacturers is their supercharged ... their website. On top of this steady flow of inside information, they have ...
(Date:2/3/2016)... Feb. 3, 2016  With the growing need ... that is underway, therapies such as monoclonal antibodies, ... whole host of indications are in high demand. ... the development and production of these therapeutics. However, ... and high costs, novel approaches and novel expression ...
(Date:2/3/2016)... BRUNSWICK, N.J. , Feb. 3, 2016 /PRNewswire-USNewswire/ ... grants totaling more than $1 million for researchers ... are working on health-related research that demonstrates exciting ... this round of funding for the New Jersey ... for faculty members at these educational institutions— Princeton ...
Breaking Biology Technology: