Navigation Links
Possible drug target found for one of the most aggressive breast cancers
Date:7/8/2009

Grand Rapids, Mich. (July 8, 2009) Van Andel Research Institute (VARI) investigators have identified a gene that could be an important therapeutic target in the treatment of the most aggressive forms of breast cancer. Currently, patients with these cancers have few treatment options.

"Breast cancer mortality rates are actually declining, but the cancers that don't respond to traditional treatments tend to be more aggressive and have decreased survival rates," said VARI Research Scientist Carrie Graveel, Ph.D., lead author of the study published this week in Proceedings of the National Academy of Sciences U.S.A.

Researchers found that the Met gene may play a critical role in the development of an aggressive form of breast cancer known as basal breast cancer.

"Met has already been associated with decreased survival in breast cancer, but this study identifies its importance in specific types that can be distinguished at the molecular level," said VARI Distinguished Scientific Fellow George Vande Woude, Ph.D., who heads the laboratory that conducted the research.

In the 1980's, Dr. Vande Woude's laboratory at the National Cancer Institute demonstrated that inappropriate levels of Met occur in human tumors, and that cells with inappropriate Met signaling dramatically impact the spread of cancer. This signaling is implicated in most types of human cancers and high Met expression often correlates with poor prognosis.

"We found Met in the majority of breast cancers," said VARI Research Technician Jack DeGroot, another of the study's authors. "But levels were highest in aggressive types, making Met a promising drug target that could help patients that currently have few treatment options."

According to the American Cancer Society, breast cancers account for more than one in four cancers diagnosed in women in the United States. The National Cancer Institute estimates that 40,170 women in the U.S. will die
'/>"/>

Contact: Joe Gavan
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. New dinosaur species possible in Northwestern Alberta
2. Study validates means to measure possible leukemia marker
3. Bovine genome provides clues to possible new developments
4. Ultrasound imaging now possible with a smartphone
5. TGen researchers discover possible way to block the spread of deadly brain tumors
6. New high-throughput screening technique makes probing puzzling proteins possible
7. Peptides-on-demand: McGill researchers radical new green chemistry makes the impossible possible
8. A research work on molluscs nacre opens new doors for its possible use in biomedicine
9. Scientists unlock possible aging secret in genetically altered fruit fly
10. Control of blood vessels a possible weapon against obesity
11. Promising new drug being evaluated as possible treatment option for fragile X syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2015)... , Apr. 6, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/143028 for MINIATURE, ... ENERGY TRANSFER  NXT-ID introduces a new ... This patent surrounds the use of miniature antenna ...
(Date:4/2/2015)... -- At its 2015 ACMG Annual Clinical Genetics Meeting ... American College of Medical Genetics and Genomics (ACMG) announced ... Members of the ACMG Board of Directors serve as ... its policies and programs. ACMG is the national organization ... eventful time in medical genetics and genomics.  We are ...
(Date:4/2/2015)... April 2, 2015 Fingerprint Cards ... sensor FPC1025 from the distributor World Peace Industrial Group ... Q2 2015 although the major part of the shipments ... be used by smartphone manufacturers in China ... included in the communicated revenue guidance of + 1 000 ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... Writing in the International Journal of Nanoparticles ... how blasting silver nitrate solution with an electron beam ... all kinds of bacteria, including gram-negative species that are ... shoes, socks and even computer keyboard may be impregnated ...
... WALL, N.J. , May 24 BIO-key International, Inc. ... today announced that Evidian has integrated BIO-key,s biometric software into its ... biometric identification solution at two major pharmaceutical companies. , ... (Logo: http://www.newscom.com/cgi-bin/prnh/20050509/BIOKEYLOGO ) , ...
... Scientists at NYU Langone Medical Center have discovered that the ... parasites, is uncommon to M. tuberculosis where the antigens remain ... Genetics on May 23, 2010, suggests that M. tuberculosis ... by the body,s immune system perhaps because the host immune ...
Cached Biology News:Antibacterial silver nanoparticles are a blast 2BIO-key(R) Biometric Identification Now Incorporated Into Evidian Enterprise Single Sign-On Solution 2BIO-key(R) Biometric Identification Now Incorporated Into Evidian Enterprise Single Sign-On Solution 3BIO-key(R) Biometric Identification Now Incorporated Into Evidian Enterprise Single Sign-On Solution 4Immune evasion common in many viruses, bacteria and parasites is uncommon in M. tuberculosis 2
(Date:5/21/2015)... W. R. Grace & Co. (NYSE: ... Germany has received good manufacturing practice (GMP) certification ... Pharmaceutical Excipient Council (IPEC) Foundation. , ... FP brand of pharmaceutical grade excipient silica gels ... Bay, Maryland (USA) and Sorocaba, Brazil locations. The ...
(Date:5/21/2015)... 21, 2015 As part of its ... (BDWMC), Sun Health Foundation funded a $3.25 million project ... pharmacy with the most up-to-date features and technology. , ... The pharmacy's 45 staff members will begin moving from ... in the coming days. , The current pharmacy ...
(Date:5/21/2015)... May 21, 2015 Veolia’s environmental ... exclusive North American distribution agreement with VWR to ... , With more than 160 years of experience, ... services for laboratory and production facilities, has cultivated ... and differentiated services to enable science. Endetec’s ...
(Date:5/20/2015)... 20, 2015 Research and Markets ( ... "Top Technologies in HW_Technical Insights" report to their ... evaluated technology trends in the Health and Wellness sector ... to have an impact in the year 2015. The ... top 10 health and wellness technologies that are anticipated ...
Breaking Biology Technology:Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 3Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Top Technologies in the Health and Wellness Industry 2015 2
... EL SEGUNDO, Calif., Nov. 16 Medical and technical ... on the International Space Station. Their efforts will help ... what might be experienced in a future mission to ... astronaut health during space exploration missions and provide us ...
... , LANSING, Mich., Nov. 16 Neogen Corporation (Nasdaq: NEOG ... 3-for-2 stock split. With the split, shareholders of record on Nov. ... two shares held. , The stock split will be effected ... in newly issued common stock on Dec. 15, 2009. As of ...
... , , SEATTLE, Nov. 16 ... "Company") today announced that the Company,s product candidate PX-866, ... Information, Inc., as one of the Top 10 most ... partnering. , The selection was made by an independent ...
Cached Biology Technology:Wyle Personnel Take Part in Important Studies Aboard the International Space Station 2Wyle Personnel Take Part in Important Studies Aboard the International Space Station 3Neogen Announces 3 for-2 Stock Split 2Oncothyreon's PX-866 PI-3 kinase inhibitor named among Top 10 most promising oncology products for partnering by Windhover 2Oncothyreon's PX-866 PI-3 kinase inhibitor named among Top 10 most promising oncology products for partnering by Windhover 3
... is designed to purify double-stranded DNA (dsDNA) generated ... PCR. The process is simple and fast. DNA ... can be efficiently purified and concentrated. The DNAclear ... bound to the Microfilter Cartridge in the presence ...
GOAT ANTI PPP2R5B...
acridine orange 10-nonyl bromide (nonyl acridine orange)...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
Biology Products: