Navigation Links
Portable device quickly detects early Alzheimer's

ATLANTA (January 16, 2008) The latest medications can delay the onset of Alzheimer's disease, but none are able to reverse its devastating effects. This limitation often makes early detection the key to Alzheimers patients maintaining a good quality of life for as long as possible.

Now, a new device developed by the Georgia Institute of Technology and Emory University may allow patients to take a brief, inexpensive test that could be administered as part of a routine yearly checkup at a doctors office to detect mild cognitive impairment (MCI) often the earliest stage of Alzheimers. The device is expected to be commercialized later this year.

Current assessment tests capable of detecting early Alzheimers typically are taken with a pen and paper or at a computer terminal and last about an hour and a half. They must be given by a trained technician in a quiet environment, because any distractions can influence the patients score and reduce the tests effectiveness. Because of their length and expense, the tests are not used as regular screening tools and typically are given only after there is obvious cognitive impairment such as forgetfulness or unsafe behavior.

Families usually wait until their mom or dad does something somewhat dangerous, like forgetting to take their medications or getting lost, before bringing them in for testing. At that point, the patient has already lost a significant portion of their cognitive function, said David Wright, MD, who helped develop the device. Wright is assistant professor of emergency medicine at Emory University School of Medicine and co-director of the Emory Emergency Medicine Research Center. With this device, we might be able to pick up impairment well before those serious symptoms occur and start patients on medications that could delay those symptoms.

The Georgia Tech and Emory device, called DETECT, gives individuals a roughly ten-minute test designed to gauge reaction time and memory functions that, when impaired, are associated with the earliest stages of Alzheimer's disease. The test is a specially modified, shortened version of the traditional pen and paper test and could be given repeatedly by doctors to evaluate any changes in cognitive functions.

We really envision this to be part of the normal preventative care a patient receives from a general practitioner, said Michelle LaPlaca, Ph.D., one of the creators of the device and an associate professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. It would be part of a regular preventative medicine exam much like a PSA test or EKG (electrocardiogram), serving as a cognitive impairment vital sign of sorts.

The portable test runs patients through a battery of visual and auditory stimuli such as pictures and words that assess cognitive abilities relative to age, gauging reaction time and memory capabilities. Its software can track cognitive capabilities and decline year to year during annual appointments. And because the device blocks outside sound and light from the patients environment, it can be administered in virtually any setting, providing more consistent results.

Preliminary analysis of the first 100 patients of a 400-person clinical study being conducted at Emory's Wesley Woods Center has shown that the 10-minute DETECT test has similar accuracy to the 90-minute Gold Standard pen and paper test.

With millions of baby boomers easing into late adulthood, the number of patients with Alzheimers is expected to skyrocket over the next few decades. More than 24 million people worldwide are currently thought to have Alzheimers disease and by 2040, an estimated 81 million people worldwide are expected to develop the disease.

To give these millions of potential Alzheimers sufferers a chance to slow the diseases advance before serious symptoms set in, doctors need an inexpensive and easy-to- administer test to detect and track the cognitive decline associated with the early stages of the disease.

The DETECT device is designed to be administered while a patient is still healthy, tracking any abnormal decreases in the patients cognitive performance over time. If a patients performance declines outside the normal range, the patient would then undergo additional testing and care from a neurologist, neuropsychologist or other specialist.

The DETECT system includes an LCD display in a visor with an onboard dedicated computer, noise reduction headphones and an input device (controller). The display projects the visual aspect of the test, the headphones provide the verbal instructions and the controller records the wearers response.

DETECTs creators have formed a company, called Zenda Technologies (, to commercialize the device for MCI, as well as other conditions. Georgia Tech and Emory researchers are exploring other types of cognitive impairment such as Attention Deficit/Hyperactivity Disorder (ADHD) that could be picked up by DETECT. A version of the system designed to detect mild concussions on the sidelines of a football game, during other high-impact sports or on a battlefield is still being tested.


Contact: Megan McRainey
Georgia Institute of Technology

Related biology news :

1. Portable electricity, life-like prosthetics on the way
2. Smiths Detection to launch a portable diagnostic system for foot-and-mouth disease and avian flu
3. Silex Introduces Worlds First Wireless USB Device Server With Streaming Video and Audio Data Transfer
4. Stanford researchers publish review of US medical device regulation
5. Device prevents potential errors in childrens medications
6. Better protection for biomedial devices could result from Rutgers-Camden research
7. EMD Serono launches easypod, new electronic growth hormone injection device
8. Atmospheric measuring device for understanding smog formation
9. MIT aids creation of neural prosthetic devices
10. IGERT fellows to design biodevices using flexible electronics
11. Researchers developing device to predict proper light exposure for human health
Post Your Comments:
(Date:10/29/2015)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is pleased to announce that it has been ... one of only three finalists for a 2015 ... Growing" category. The Tekne Awards honor Minnesota ... innovation and leadership. iMedNet™ eClinical ...
(Date:10/29/2015)... OXFORD, Connecticut , October 29, 2015 /PRNewswire/ ... "Company"), a biometric authentication company focused on the ... Wocket® smart wallet announces that StackCommerce, a leading ... will be featuring the Wocket® smart wallet on ... NXTD ) ("NXT-ID" or the "Company"), a ...
(Date:10/26/2015)... 26, 2015 ... adds Biometrics Market Shares, Strategies ... well as Emerging Biometrics Technologies: Global ... its collection of IT and Telecommunications ... --> . ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... ... November 25, 2015 , ... Jessica Richman and Zachary Apte, ... their initial angel funding process. Now, they are paying it forward to other ... stage investments in the microbiome space. In this, they join other successful ...
(Date:11/24/2015)... ... , ... The United States Golf Association (USGA) today announced Dr. Bruce Clarke, ... annually since 1961, the USGA Green Section Award recognizes an individual’s distinguished service to ... Clarke, of Iselin, N.J., is an extension specialist of turfgrass pathology in the department ...
(Date:11/24/2015)... Halozyme Therapeutics, Inc. (NASDAQ: HALO ) will be presenting at ... on Wednesday, December 2 at 9:30 a.m. ET/6:30 a.m. PT ... provide a corporate overview. th Annual Oppenheimer Healthcare ... ET/10:00 a.m. PT . Jim Mazzola , vice president ... --> th Annual Oppenheimer Healthcare Conference in ...
(Date:11/24/2015)... ... November 24, 2015 , ... Copper is an essential micronutrient ... to proteins, copper is also toxic to cells. With a $1.3 million award ... will conduct a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. ...
Breaking Biology Technology: