Navigation Links
Poor response to anti-anemia drug predicts higher risk of heart disease or death
Date:12/28/2010

quire dialysis. Of these, 1,872 received injections of the drug, and 1,889 received placebo injections.

Participants receiving darbepoetin alpha also received periodic subcutaneous injections of the drug with the aim of increasing their levels of hemoglobin a protein in red blood cells that carries oxygen to a level of 13 grams per deciliter. If someone in the control group dropped to a dangerous hemoglobin level below 9 g/dl, he or she received "rescue therapy" with darbepoetin until the hemoglobin level returned to a level above 9 g/dl.

In analyzing the results, the researchers divided the participants into two groups: those whose hemoglobin levels promptly increased in response to early doses of darbepoetin alpha, and those whose bodies responded less strongly, with hemoglobin level staying low.

The participants who had poor initial responses to the drug had a higher rate of death, heart attack, stroke or heart failure, the researchers found.

The study cannot show whether those people had higher risk for those outcomes because they were in poorer health to begin with, or because of some action of the drug, the researchers stated.

However, it does raise the question of whether treatment for anemia should be customized according to a patient's response to the drug, Dr. Toto said.

"Our studies suggest that we might be able to use the initial dose response to identify high-risk groups in future studies," he said.

For instance, if a person's hemoglobin level doesn't improve within one or two months of anti-anemia treatment, it may be better to stop the drug and seek alternative treatment. A state of mild anemia might pose less cardiovascular risk in such a case than continuing or escalating the dose in an attempt to reach a normal hemoglobin level, Dr. Toto said. Conversely, for patients who respond quickly to the drug, treating them until they reach the normal goal range recommended by the Food an
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Millisecond brain signals predict response to fast-acting antidepressant
2. RNA molecules, delivery system improve vaccine responses, effectiveness
3. Response to immune protein determines pathology of multiple sclerosis
4. Forsyth scientists trigger cancer-like response from embryonic stem cells
5. NIAID funds studies of how SARS and bird flu evade antiviral responses
6. How eating fruit and vegetables can improve cancer patients response to chemotherapy
7. Lung airway cells activate vitamin D and increase immune response
8. Top scientific meeting urges coordinated response to economic and environmental crises
9. New type of vaccines deliver stronger and faster immune response
10. Researchers engineer pancreatic cell transplants to evade immune response
11. Slight changes in climate may trigger abrupt ecosystem responses
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Poor response to anti-anemia drug predicts higher risk of heart disease or death
(Date:8/31/2014)... us, germs go after each other. But when viruses ... infected microbes: Sometimes viruses actually carry helpful genes that ... or better attack its own hosts. , Scientists have ... robotically destroy anything it recognized as invading viral genes. ... that one variety of the bacterial immune system known ...
(Date:8/31/2014)... malaria diagnosis has changed very little. After taking a blood ... a glass slide, stains it with a special dye, and ... the disease. This approach gives an accurate count of how ... of disease severity but is not ideal because there ... the Singapore-MIT Alliance for Research and Technology (SMART) has now ...
(Date:8/29/2014)... Scientists at the Barshop Institute for Longevity and Aging ... UT Health Science Center at San Antonio, have found ... longest-lived rodent, the naked mole rat. , They ... mole rats protects and alters the activity of the ... , The factor also protects proteasome function in human, ...
Breaking Biology News(10 mins):Discovery reveals how bacteria distinguish harmful vs. helpful viruses 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 3A new way to diagnose malaria 2A new way to diagnose malaria 3Factor in naked mole rat's cells enhances protein integrity 2
... laser scanning technology allows researchers to tote their latest ... the form of lightweight digital data stored on a ... with others requires standard formats that are currently lacking, ... The SMU researchers used portable laser scanning technology to ...
... Spanish legislation stipulates that at least 60% of waste paper ... glass, 50% of metals and 22.5% of plastics. However, a ... Castelln shows that this minimum requirement is only exceeded in ... paper and cardboard stands at 45% in the best of ...
... has discovered that human-introduced, invasive species of plants can ... of biology at Penn State University, and Jason Gleditsch, ... studied how invasive fruiting plants affect ecosystems and how ... beneficial to an ecological community. The team,s research, which ...
Cached Biology News:3-D digital dinosaur track download: A roadmap for saving at-risk natural history resources 23-D digital dinosaur track download: A roadmap for saving at-risk natural history resources 33-D digital dinosaur track download: A roadmap for saving at-risk natural history resources 4Spanish cities fail to meet legal requirements on paper and container recycling 2Invasive plants can create positive ecological change 2Invasive plants can create positive ecological change 3Invasive plants can create positive ecological change 4
(Date:8/31/2014)... Available spectra is similar for ... and cultivation of a wide range of plants. ... with proven patented and pending wide spectrum technology. ... in critical applications in contrast to growth spectra ... customers have a large variety of differently sized ...
(Date:8/29/2014)... Inc. (NYSE MKT: PFNX), a clinical-stage biotechnology company ... to manufacture proteins including biosimilar therapeutics, today provided ... the second quarter ended June 30, 2014. ... public offering, we have the capital to continue ... our proprietary protein expression platform," stated Bertrand C. ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Pittcon is ... MacDonald, and colleague Koichiro Matsuda, Horiba Scientific, have organized ... September 5, 2014. JASIS , Asia’s largest analytical ... 2014, in Makuhari Messe, Japan. , The four ... for Bioanalysis from Single Molecules to Single Cells” will ...
(Date:8/29/2014)... August 29, 2014 Due to a misstatement ... week, the Adult Stem Cell Technology Center, LLC ( ASCTC ... stem cell therapy research that might benefit ALS patients. ... for new stem cell technologies and therapeutic applications, FRC listed ... Bucket Challenge donors who wish not to support research ...
Breaking Biology Technology:Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3
... Modern Mobility Aids, Inc. (OTCBB: MDRM) (the "Company") is ... required to execute its closing agreement to acquire all ... Modern Mobility Aids, Inc. is a Nevada-based ... development in the Bio-Pharma sector as well as scalable ...
... many polyhedral nanocrystals of silver can be packed into ... but the answer holds importance for one of today,s ... U.S. Department of Energy (DOE),s Lawrence Berkeley National Laboratory ... simpler approach for the fabrication of plasmonic materials by ...
... 22, 2011 SuperNova Diagnostics®, Inc., a privately-held global diagnostics ... Neil J. Campbell, President and CEO, will be presenting ... November 30, 2011 at 10:30 a.m. ET at the ... The presentation will include an overview of ...
Cached Biology Technology:Modern Mobility Aids, Inc. Secures Financing to Close Acquisition Agreement of LumiGene Technologies 2Modern Mobility Aids, Inc. Secures Financing to Close Acquisition Agreement of LumiGene Technologies 3On the road to plasmonics with silver polyhedral nanocrystals 2On the road to plasmonics with silver polyhedral nanocrystals 3SuperNova Diagnostics® to Present at the 23rd Annual Piper Jaffray Healthcare Conference in New York City 2
... LX80L is an extension of Parkers MX80 family ... compact cross-section. LX80L bolt hole patterns mimic the ... units and all accessory brackets to build multi-axis ... travel to 750 mm , Accelerations to 5 ...
... from the C-terminal end of the mouse retinoic acid receptor beta (RAR*). ... 448 of RAR*. The sequence of PEP-005 is (amino to carboxy ... - S - S - V - E - N - S ... - L - L - Q (The N-terminal cysteine has been ...
... Neural Stem Cell Kit with Medium High ... complete with optimized base medium for growth ... these unique cells generated from E18 fetal ... for a tissue-like mixture of in vitro ...
... The potential applications for the use of ... gene expression via the RNA interference (RNAi) ... cellular and molecular biology fields. siRNA for ... either chemically or enzymatically, and then transfected ...
Biology Products: