Navigation Links
Polyphenol antioxidants inhibit iron absorption
Date:8/23/2010

University Park, Pa. Health benefits from polyphenol antioxidants substances found in many fruits and vegetables may come at a cost to some people. Penn State nutritional scientists found that eating certain polyphenols decreased the amount of iron the body absorbs, which can increase the risk of developing an iron deficiency.

"Polyphenols have been known to have many beneficial effects for human health, such as preventing or delaying certain types of cancer, enhancing bone metabolism and improving bone mineral density, and decreasing risk of heart disease," said Okhee Han, assistant professor of nutritional sciences. "But so far, not many people have thought about whether or not polyphenols affect nutrient absorption."

The researchers, led by Han, studied the effects of eating grape seed extract and epigallocatechin-3-gallate (EGCG) found in green tea. They used cells from the intestine where iron absorption takes place to assess the polyphenols' effect and found that polyphenols bind to iron in the intestinal cells, forming a non-transportable complex. This iron-polyphenol complex cannot enter the blood stream. Instead, it is excreted in the feces when cells are sloughed off and replaced.

Iron is necessary to carry oxygen from the lungs throughout the body and for other cellular functions. People already at risk for iron deficiency increase that risk if they consume high amounts of grape seed extract or EGCG.

"Iron deficiency is the most prevalent nutrient deficiency in the world, especially in developing countries where meats are not plentiful," said Han. "People at high risk of developing iron deficiency such as pregnant women and young children should be aware of what polyphenols they are consuming."

Han and her colleagues looked at the heme form of iron found in meats, poultry, and fish. Last year, they performed similar research with non-heme iron found in plants. They published the results of their study on grape seed extract and EGCG in the Journal of Nutrition, showing that eating polyphenols decreased iron absorption.

Both grape seed extract and EGCG are sold in extract form. The results of these studies suggest that consumers should be cautious if using these products.

Han and her colleagues recently received a grant from the National Institutes of Health, National Center for Complementary and Alternative Medicine to expand this research. They will conduct animal studies and eventually hope to do human studies as well. Other authors on the paper include Qianyi Ma, graduate student in nutritional sciences, and Eun-Young Kim, research assistant in nutritional sciences.


'/>"/>

Contact: Liam Jackson
lnj104@psu.edu
814-863-4325
Penn State
Source:Eurekalert

Related biology news :

1. Mounting evidence shows health benefits of grape polyphenols
2. Want to slow aging? New research suggests it takes more than antioxidants
3. Antioxidants do help arteries stay healthy
4. Well-defined quantity of antioxidants in diet can improve insulin resistance
5. University of Colorado study shows natural antioxidants give top barn swallows a leg on competitors
6. Antioxidants arent always good for you and can impair muscle function, study shows
7. Scientists discover influenzas Achilles heel: Antioxidants
8. Antioxidants in Midwestern black raspberries influenced by production site
9. Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
10. Purple tomatoes: The richness of antioxidants against tumors
11. Research shows Brazilian acai berry antioxidants absorbed by human body
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
(Date:6/2/2016)... YORK , June 2, 2016   The Weather ... is announcing Watson Ads, an industry-first capability in which consumers ... by being able to ask questions via voice or text ... Marketers have long sought ... the consumer, that can be personal, relevant and valuable; and ...
(Date:5/24/2016)... patient care by providing unparalleled technology to leaders of the medical imaging industry.  As ... added to the range of products distributed by Ampronix. Photo - ... ... ... ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension of ... higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... of the cuvette holder. , FireflySci has developed several Agilent flow cell product ...
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. ... test has received AOAC Research Institute approval 061601. , “This is another AOAC-RI ... stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... launch of the Supplyframe Design Lab . Located in Pasadena, Calif., the ... future of how hardware projects are designed, built and brought to market. , ...
Breaking Biology Technology: