Navigation Links
Polycyclic aromatic hydrocarbons in smokeless tobacco products
Date:10/24/2013

A new study shows that the concentration of polycyclic aromatic hydrocarbons (PAHs) in smokeless tobacco products (STPs) can differ by as much as 60 fold, with the highest levels in moist snuff, and dry snuff and soft pellets; the lowest levels were in snus. Higher levels can be explained by the use of of fire-cured tobaccos in the products. The source of the trace amounts of PAHs in snus and other products using non-fire-cured tobaccos was previously unknown. The results of this study indicate the source to be environmental pollution, such as car exhausts and agricultural and wood fires.

Scientists at British American Tobacco and the University of Louisville analysed 70 contemporary STPs, representing 80-90% of market share in Sweden and the USA, including chewing tobacco, dry and moist snuff (dipping tobacco), hard and soft pellets, plug, and loose and portion snus, for 21 PAHs.

PAHs are produced during the incomplete burning of organic material such as coal, oil, gas, wood, and tobacco. They do not occur naturally in plants such as tobacco, but can be created during the drying (curing) process, for example, if the tobacco leaf is exposed to exhaust gases from heat sources that rely on burning wood, this can increase PAH level. Fire-cured tobaccos, whose production involves direct contact of the tobacco leaf with wood smoke, contain particularly high concentrations of PAHs.

The US Food and Drug Administration, has identified 15 PAHs as harmful or potentially harmful constituents in tobacco, and one, benzo(a)pyrene (B[a]P), is a known human carcinogen. This comprehensive analysis did not find seven of the FDA-specified PAHs in any of the STPs tested. However, it provided benchmark quantitative information on the PAHs in contemporary STPs used in Sweden and the USA.

In this study, PAHs were found in all STPs tested, but there were significant differences in the total and individual PAH concentrations in the different product styles. Substantially higher levels of total PAHs (10-60 fold) were found in moist and dry snuff and soft pellets than in the other STPs.

To establish the sources of PAHs in STPs, the researchers looked at ratios of different PAHs, which have previously been shown in a number of environmental and food matrices to differ according to source. Analysis confirmed that the use of fire-cured tobaccos in the snuffs and soft pellet were the major source of PAHs in these products suggesting this method can be used as a diagnostic tool to identify the source of PAHs in STPs.

Analysis also indicated, for the first time, a variety of contributors to the trace levels of PAHs in snus and other STPs. For example, lower temperature petrol-based sources (such as car exhaust fumes) and higher temperature combustion sources (such as agricultural or wood fires) appeared to be important contributors to PAHs in snus. The researchers note that such environmental pollution could be difficult to avoid.

'Data from this research will help scientists and regulators understand the diversity of tobacco products and the substantial differences in toxicant levels between these STP categories,' says Kevin McAdam, lead author of the study and Principal Scientist at British American Tobacco. 'Moreover, the use of the diagnostic analysis of PAH ratios represents a valuable tool for understanding where PAH contamination of STPs arises'.

Additionally, the study identified strong correlations between B[a]P and all the other PAHs except the naphthalenes. As there are well established methods for determining B[a]P in tobacco, this finding suggests that B[a]P could be used as a good surrogate marker for many PAHs in STPs.


'/>"/>

Contact: Dr Marina Murphy
marina_murphy@bat.com
44-077-111-50135
R&D at British American Tobacco
Source:Eurekalert

Related biology news :

1. A new breed of stable anti-aromatic compound
2. Leader of smoking cessation and tobacco prevention efforts receives Institute of Medicines 2013 Lienhard Award
3. AACR news: Misregulated genes common to tobacco-related cancers offer potential new prognostic tool
4. Experts believe plain packaging of tobacco products would cut smoking
5. Giant tobacco plants that stay young forever
6. Deterring signals: Tobacco plants advertise their defensive readiness to attacking leafhoppers
7. Finland to lead the way as a designer of cellulose-based products
8. Legionella bacteria found in compost products
9. hESC Products Market: Human Embryonic Stem Cell Patent IP Landscape Opportunity Analysis in New Research Report
10. The new frontier: Creating and marketing food products that prevent disease and obesity
11. REFORM, opening up the way for low environmental impact products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... Solutions, a global clinical research organization (CRO), announces the launch of ... 4, 2017. Shadow is designed to assist medical writers and biometrics ... the European Medicines Agency (EMA) in meeting the requirements for de-identifying ... ... ...
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 ... a leader in dairy research, today announced a new ... help reduce the chances that the global milk supply ... this dairy project, Cornell University has become the newest ... Food Supply Chain, a food safety initiative that includes ...
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer ... treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and bind ...
(Date:10/10/2017)... International research firm Parks Associates announced today that Tom ... 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer ... first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With ... with the challenge of how to continue to feed a growing nation. At the ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C kit. Researchers ... perform Hi-C metagenome deconvolution using their own facilities, supplementing the company’s full-service ...
Breaking Biology Technology: