Navigation Links
Polycyclic aromatic hydrocarbons in smokeless tobacco products

A new study shows that the concentration of polycyclic aromatic hydrocarbons (PAHs) in smokeless tobacco products (STPs) can differ by as much as 60 fold, with the highest levels in moist snuff, and dry snuff and soft pellets; the lowest levels were in snus. Higher levels can be explained by the use of of fire-cured tobaccos in the products. The source of the trace amounts of PAHs in snus and other products using non-fire-cured tobaccos was previously unknown. The results of this study indicate the source to be environmental pollution, such as car exhausts and agricultural and wood fires.

Scientists at British American Tobacco and the University of Louisville analysed 70 contemporary STPs, representing 80-90% of market share in Sweden and the USA, including chewing tobacco, dry and moist snuff (dipping tobacco), hard and soft pellets, plug, and loose and portion snus, for 21 PAHs.

PAHs are produced during the incomplete burning of organic material such as coal, oil, gas, wood, and tobacco. They do not occur naturally in plants such as tobacco, but can be created during the drying (curing) process, for example, if the tobacco leaf is exposed to exhaust gases from heat sources that rely on burning wood, this can increase PAH level. Fire-cured tobaccos, whose production involves direct contact of the tobacco leaf with wood smoke, contain particularly high concentrations of PAHs.

The US Food and Drug Administration, has identified 15 PAHs as harmful or potentially harmful constituents in tobacco, and one, benzo(a)pyrene (B[a]P), is a known human carcinogen. This comprehensive analysis did not find seven of the FDA-specified PAHs in any of the STPs tested. However, it provided benchmark quantitative information on the PAHs in contemporary STPs used in Sweden and the USA.

In this study, PAHs were found in all STPs tested, but there were significant differences in the total and individual PAH concentrations in the different product styles. Substantially higher levels of total PAHs (10-60 fold) were found in moist and dry snuff and soft pellets than in the other STPs.

To establish the sources of PAHs in STPs, the researchers looked at ratios of different PAHs, which have previously been shown in a number of environmental and food matrices to differ according to source. Analysis confirmed that the use of fire-cured tobaccos in the snuffs and soft pellet were the major source of PAHs in these products suggesting this method can be used as a diagnostic tool to identify the source of PAHs in STPs.

Analysis also indicated, for the first time, a variety of contributors to the trace levels of PAHs in snus and other STPs. For example, lower temperature petrol-based sources (such as car exhaust fumes) and higher temperature combustion sources (such as agricultural or wood fires) appeared to be important contributors to PAHs in snus. The researchers note that such environmental pollution could be difficult to avoid.

'Data from this research will help scientists and regulators understand the diversity of tobacco products and the substantial differences in toxicant levels between these STP categories,' says Kevin McAdam, lead author of the study and Principal Scientist at British American Tobacco. 'Moreover, the use of the diagnostic analysis of PAH ratios represents a valuable tool for understanding where PAH contamination of STPs arises'.

Additionally, the study identified strong correlations between B[a]P and all the other PAHs except the naphthalenes. As there are well established methods for determining B[a]P in tobacco, this finding suggests that B[a]P could be used as a good surrogate marker for many PAHs in STPs.


Contact: Dr Marina Murphy
R&D at British American Tobacco

Related biology news :

1. A new breed of stable anti-aromatic compound
2. Leader of smoking cessation and tobacco prevention efforts receives Institute of Medicines 2013 Lienhard Award
3. AACR news: Misregulated genes common to tobacco-related cancers offer potential new prognostic tool
4. Experts believe plain packaging of tobacco products would cut smoking
5. Giant tobacco plants that stay young forever
6. Deterring signals: Tobacco plants advertise their defensive readiness to attacking leafhoppers
7. Finland to lead the way as a designer of cellulose-based products
8. Legionella bacteria found in compost products
9. hESC Products Market: Human Embryonic Stem Cell Patent IP Landscape Opportunity Analysis in New Research Report
10. The new frontier: Creating and marketing food products that prevent disease and obesity
11. REFORM, opening up the way for low environmental impact products
Post Your Comments:
(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... on what they believe could be a new and helpful biomarker for malignant ... Click here to read it now. , Biomarkers are components in ...
(Date:6/27/2016)... BOSTON , June 27, 2016   Ginkgo ... biology to industrial engineering, was today awarded as ... a selection of the world,s most innovative companies. ... at scale for the real world in the ... organism engineers work directly with customers including Fortune ...
(Date:6/23/2016)... WA (PRWEB) , ... June 23, 2016 , ... ... announces the release of its second eBook, “Clinical Trials Patient Recruitment and Retention ... recruitment and retention in this eBook by providing practical tips, tools, and strategies ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
Breaking Biology Technology: