Navigation Links
Pocket chemistry: DNA helps glucose meters measure more than sugar
Date:7/24/2011

CHAMPAIGN, Ill. Glucose meters aren't just for diabetics anymore. Thanks to University of Illinois chemists, they can be used as simple, portable, inexpensive meters for a number of target molecules in blood, serum, water or food.

Chemistry professor Yi Lu and postdoctoral researcher Yu Xiang published their findings in the journal Nature Chemistry.

"The advantages of our method are high portability, low cost, wide availability and quantitative detection of a broad range of targets in medical diagnostics and environmental monitoring," Lu said. "Anyone could use it for a wide range of detections at home and in the field for targets they may care about, such as vital metabolites for a healthy living, contaminants in their drinking water or food, or potential disease markers."

A glucose meter is one of the few widely available devices that can quantitatively detect target molecules in a solution, a necessity for diagnosis and detection, but only responds to one chemical: glucose. To use them to detect another target, the researchers coupled them with a class of molecular sensors called functional DNA sensors.

Functional DNA sensors use short segments of DNA that bind to specific targets. A number of functional DNAs and RNAs are available to recognize a wide variety of targets.

They have been used in the laboratory in conjunction with complex and more expensive equipment, but Lu and Xiang saw the potential for partnering them with pocket glucose meters.

The DNA segments, immobilized on magnetic particles, are bound to the enzyme invertase, which can catalyze conversion of sucrose (table sugar) to glucose. The user adds a sample of blood, serum or water to the functional DNA sensor to test for drugs, disease markers, contaminants or other molecules. When the target molecule binds to the DNA, invertase is released into the solution. After removing the magnetic particle by a magnet, the glucose level of the sample rises in proportion to the amount of invertase released, so the user then can employ a glucose meter to quantify the target molecule in the original sample.

"Our method significantly expands the range of targets the glucose monitor can detect," said Lu, who also is affiliated with the Beckman Institute for Advanced Science and Technology and with the Frederick Seitz Materials Research Lab at U. of I. "It is simple enough for someone to use at home, without the high costs and long waiting period of going to the clinics or sending samples to professional labs."

The researchers demonstrated using functional DNA with glucose meters to detect cocaine, the disease marker interferon, adenosine and uranium. The two-step method could be used to detect any kind of molecule that a functional DNA or RNA can bind.

Next, the researchers plan to further simplify their method, which now requires users to first apply the sample to the functional DNA sensor and then to the glucose meter.

"We are working on integrating the procedures into one step to make it even simpler," Lu said. "Our technology is new and, given time, it will be developed into an even more user-friendly format."


'/>"/>

Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Related biology news :

1. BIO-key(R) Awarded PocketCop(R) Contracts From Major Law Enforcement Agencies
2. A pocketful of uranium
3. CCNY biologists identify new spiny pocket mouse species
4. Sorting device for analyzing biological reactions puts the power of a lab in a researcher’s pocket
5. Author predicts widespread acceptance of pocket-sized ultrasound machines
6. Sweet chemistry: Carbohydrate adhesion gives stainless steel implants beneficial new functions
7. MSU scientists find new gene that helps plants beat the heat
8. Extreme nature helps scientists design nano materials
9. Diatom genome helps explain success in trapping excess carbon in oceans
10. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
11. Swamping bad cells with good in ALS animal models helps sustain breathing
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pocket chemistry: DNA helps glucose meters measure more than sugar
(Date:6/14/2017)... PARIS , June 15, 2017  IBM (NYSE: IBM ... the international tech event dedicated to developing collaboration between startups ... on June 15-17. During the event, nine startups will ... deliver value in various industries. ... in the international market, with a 30 percent increase in ...
(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
(Date:4/13/2017)... India , April 13, 2017 According to ... Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, ... MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 Billion ... Growth Rate (CAGR) of 17.3%. ... MarketsandMarkets ...
Breaking Biology News(10 mins):
(Date:6/28/2017)... -- Scientific Analytics, Inc.,s DARI Motion Health is one of the ... healthcare providers at Premier Inc.,s 2017 Breakthroughs Conference and ... Motion Health was debuted during the conference,s annual Innovation ... industry suppliers committed to innovation and improving patient outcomes. ... ...
(Date:6/28/2017)... ... June 28, 2017 , ... Alevio, LLC ( http://www.aleviospine.com ... 500th case using the SiCure Sacroiliac Joint Fusion System. , SiCure is a ... can be implanted in either a lateral or posterior approach, and is indicated ...
(Date:6/28/2017)... New York and London, June 28, 2017 (PRWEB) , ... ... ... The latest release of Siemens’ STAR-CCM+® software for multiphysics ... features which enable automated product design exploration and optimization. STAR-CCM+ version 12.04 ...
(Date:6/27/2017)... ... June 27, 2017 , ... The recent vote by the ... a disease gives new hope to patients and hopefully sheds new light on the ... M.D. , an infertility expert and founding partner of Texas Fertility Center . ...
Breaking Biology Technology: