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Plants can be used to study how and why people respond differently to drugs
Date:9/26/2007

statin.

Cutler and his team found that the plants UGT activates hypostatin by adding a sugar molecule to it. They also found that in plants that had a genetically defective UGT, hypostatin did not work properly because no sugar molecules necessary for activating hypostatin were added to it; in such plants, therefore, growth was not affected.

This mechanism is very similar to that seen in humans, where altered drug sensitivity can occur because of defective or atypical sugar-tagging proteins, Cutler said.

His lab made the discovery as part of its ongoing research aimed at identifying and characterizing new bioactive compounds in plants. Next in their research, Cutler and his colleagues plan to expand their search for other sugar-activated molecules, like hypostatin.


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Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert

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