Plants can be used to study how and why people respond differentl...( RIVERSIDE Calif. While prescription...)

RIVERSIDE, Calif. While prescription medications work successfully to cure an ailment in some people, in others the same dose of the same drug can cause an adverse reaction or no response at all.

According to a research team led by Sean Cutler, an assistant professor of plant cell biology at UC Riverside, such variation in drug responses can be analyzed by studying much simpler organisms like plants.

The genetics behind variable drug responses is not peculiar to humans but exists also in other branches on the tree of life, Cutler said. We can harness simple organisms to understand more about the genetics and biochemistry of variable drug responses, which could help uncover new factors that contribute to variable drug responses in humans.

Study results appear in the Sept. 23 online publication of Nature Chemical Biology.

Focusing on Arabidopsis thaliana, a weedy plant in the mustard family, Cutlers lab discovered a key protein in the plant that creates drug resistance. Called UGT (UDP-glycosyltransferase), the protein is a member of a family of proteins that also affect drug sensitivity in humans.

Similar biochemical processes are affecting drug sensitivity in both plants and animals, said Cutler, who joined UCRs Department of Botany and Plant Sciences and the Center for Plant Cell Biology in January 2007. These similarities suggest that plants can be useful for studying problems of human interest like drug responses.

In their research, Cutler and his research team first screened and tested thousands of drug-like compounds in the lab as they searched for new inhibitors of plant growth. In the process, they discovered a new molecule, called hypostatin, which acts like a drug in inhibiting plant growth in some Arabidopsis plants.

At the same time, the researchers grew Arabidopsis plants in a solution containing hypostatin, which allowed the plant cells to take up hypo
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