Navigation Links
Plants can be used to study how and why people respond differently to drugs
Date:9/26/2007

RIVERSIDE, Calif. While prescription medications work successfully to cure an ailment in some people, in others the same dose of the same drug can cause an adverse reaction or no response at all.

According to a research team led by Sean Cutler, an assistant professor of plant cell biology at UC Riverside, such variation in drug responses can be analyzed by studying much simpler organisms like plants.

The genetics behind variable drug responses is not peculiar to humans but exists also in other branches on the tree of life, Cutler said. We can harness simple organisms to understand more about the genetics and biochemistry of variable drug responses, which could help uncover new factors that contribute to variable drug responses in humans.

Study results appear in the Sept. 23 online publication of Nature Chemical Biology.

Focusing on Arabidopsis thaliana, a weedy plant in the mustard family, Cutlers lab discovered a key protein in the plant that creates drug resistance. Called UGT (UDP-glycosyltransferase), the protein is a member of a family of proteins that also affect drug sensitivity in humans.

Similar biochemical processes are affecting drug sensitivity in both plants and animals, said Cutler, who joined UCRs Department of Botany and Plant Sciences and the Center for Plant Cell Biology in January 2007. These similarities suggest that plants can be useful for studying problems of human interest like drug responses.

In their research, Cutler and his research team first screened and tested thousands of drug-like compounds in the lab as they searched for new inhibitors of plant growth. In the process, they discovered a new molecule, called hypostatin, which acts like a drug in inhibiting plant growth in some Arabidopsis plants.

At the same time, the researchers grew Arabidopsis plants in a solution containing hypostatin, which allowed the plant cells to take up hypo
'/>"/>

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert

Page: 1 2

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Plants, animals share molecular growth mechanisms
3. Plants respond similarly to signals from friends, enemies
4. Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa
5. Plants defy Mendels inheritance laws, may prompt textbook changes
6. Antibodies from plants protect against anthrax
7. New RNA polymerase discovered in plants
8. Transgenic plants remove more selenium from polluted soil than wild plants, new tests show
9. Scientists discover how plants disarm the toxic effects of excessive sunlight
10. Defenseless plants arm themselves with metals
11. At long last, scientists figure out how plants grow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Aug. 21, 2014 Nxt-ID, Inc. (OTCQB: NXTD), ... commerce market, announced today that its shares of common ... be issued in its proposed underwritten public offering of ... on The Nasdaq Capital Market, subject to closing of ... and warrants, and will trade under the symbol "NXTD" ...
(Date:8/21/2014)... ubiquitous skin fungus linked to dandruff, eczema and other ... to even further global reachesincluding Hawaiian coral reefs and ... vents. , A review in the scientific journal ... of the fungi of the genus Malassezia ... sequencing datasets from around the world. , University of ...
(Date:8/21/2014)... -- Nine researchers from Beth Israel Deaconess ... in "The World,s Most Influential Scientific Minds 2014," ... Thomson Reuters ScienceWatch, a web resource for science metrics ... recognized as among the most influential "are performing and ... the advancement of their science," according to a Thomson ...
Breaking Biology News(10 mins):Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3
... commercially available mineral waters, the researchers found evidence of ... the water. What,s more, these chemicals are potent in ... in the New Zealand mud snail. These findings, which ... of plastic food packaging materials act as functional estrogens, ...
... diseases that can travel with the wind have the ... understood, according to a new study, in findings that ... but also a new fungus that threatens global wheat ... State University and other institutions, concluded that invading diseases ...
... is available in Spanish . , ... of psychosis and schizophrenia, and those episodes of psychosis ... characteristics, both before their appearance and in the clinical ... conclusions of the doctoral thesis "Neurodevelopment and environmental stress ...
Cached Biology News:Hormone-mimics in plastic water bottles -- just the tip of the iceberg? 2New wheat disease could spread faster than expected 2New wheat disease could spread faster than expected 3Daily consumption of cannabis predisposes to the appearance of psychosis and schizophrenia 2
(Date:8/22/2014)... Albany, New York (PRWEB) August 22, 2014 ... represent one of the interesting and challenging endeavors ... eye renders highly impervious properties to the foreign ... such as possibility of self medication and minimal ... of low molecular weight drugs and provides specific ...
(Date:8/22/2014)... Los Angeles (PRWEB) August 22, 2014 ... for age-defying products, is in the spotlight again. ... night cream and its NeriumFirmTM Body Contouring Cream ... presented by Backstage Creations during the 66th Primetime ... the patented NAE-8® extract, third-party clinical trials show ...
(Date:8/21/2014)... the Institute for Molecular Medicine Finland (FIMM), University ... a novel "man and machine" decision support system ... was described in PLOS One scientific ... on computer vision algorithms similar to those used ... only the diagnostically most relevant areas. Tablet computers ...
(Date:8/21/2014)... 21, 2014 Telomere Biosciences, LLC (Telomere ... "TELO-20 for Dogs" with Telomerase Activation Complex ... the world for dogs. Telomeres are the protective ... the body. A wealth of ground-breaking research by ... Science and Aging, including Nobel laureates, has demonstrated ...
Breaking Biology Technology:Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 4Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3
... of decorative, flower-like defects in the nanomaterial graphene could ... electrical and mechanical properties, according to researchers at the ... Tech. In a new paper,* the team for the ... could occur naturally or be induced to occur in ...
... of the March 11 earthquake and rolling blackouts that ... award-winning undergraduate internship program NanoJapan is scrambling to run ... U.S. undergraduates travel to Japan for lab internships, NanoJapan ... send 25-30 students to Rice University laboratories for three ...
... May 25, 2011 Anadys Pharmaceuticals, Inc. (Nasdaq: ... the treatment of hepatitis C, announced today that it will ... the Company,s oral immuno-modulator that acts via the TLR-7 pathway, ... Meeting in Chicago, IL.  The data from the completed Phase ...
Cached Biology Technology:Defect in graphene may present bouquet of possibilities 2Reverse NanoJapan: Rice to host 25-30 Japanese students 2Anadys Highlights ANA773 Data to be Presented at ASCO 2Anadys Highlights ANA773 Data to be Presented at ASCO 3Anadys Highlights ANA773 Data to be Presented at ASCO 4
... The CHEMICON APO-BRDU Kit is ... labeling DNA breaks and total cellular DNA ... The kit contains the instructions and ... including; positive and negative control cells for ...
... overlay agarose, is a low melting point ... to secure IPG strips in place for ... incorporated to allow monitoring of electrophoresis runs. ... melting point agarose in 1x Tris, glycine, ...
... cell is an apparatus dedicated to general ... agarose slab gels. The cell includes the ... tray, 5 glass plates, 50 sheets of ... templates, and instructions. Dimensions are 21 x ...
... range of next-generation features into a small-footprint ... for flexible laboratory solutions. It puts every ... dilution, dispensing, and integrations into a ... flexible as it is efficient and economical. ...
Biology Products: