Navigation Links
Plant used in Chinese medicine fights chronic pain
Date:1/2/2014

A plant used for centuries as a pain reliever in Chinese medicine may be just what the doctor ordered, especially when it comes to chronic pain. A key pain-relieving ingredient is a compound known as dehydrocorybulbine (DHCB) found in the roots of the flowering plant Corydalis, a member of the poppy family, according to researchers who report their findings in the Cell Press journal Current Biology on January 2.

"Our study reports the discovery of a new natural product that can relieve pain," says Olivier Civelli of the University of California, Irvine. "This analgesic acts in animal assays against the three types of pain that afflict humans, including acute, inflammatory, and neuropathic or chronic pain."

Civelli, along with Xinmiao Liang, made the discovery as part of the "herbalome" project, an effort to catalogue all of the chemical components of traditional Chinese medicine. The Corydalis plants that were the focus of the new study grow mainly in central eastern China, where underground tubers are harvested, ground, and boiled in hot vinegar. Those concoctions are often prescribed to treat pain, including headaches and back pain.

The researchers went looking for compounds in Corydalis that appeared likely to act in a manner similar to morphine. "We landed on DHCB but rapidly found that it acts not through the morphine receptor but through other receptors, in particular one that binds dopamine," Civelli explains. The discovery adds to earlier evidence showing that the dopamine D2 receptor plays a role in pain sensation.

While Corydalis extracts or isolated DHCB work against all types of pain, they hold special promise for those who suffer with persistent, low-level chronic pain. For one thing, DHCB doesn't appear to lose effectiveness with time in the way that traditional opiate drugs do.

"We have good pain medications for acute pain: codeine or morphine, for example," Civelli says. "We have pain medication for inflammatory pain, such as aspirin or acetaminophen. We do not have good medications for chronic pain. DHCB may not be able to relieve strong chronic pain, but may be used for low-level chronic pain."

Although Corydalis preparations of various types can already be purchased online, Civelli and Liang say DHCB isn't ready for prime time just yet. Further testing for toxicity is needed before doctors should consider prescribing it to patients.


'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related biology news :

1. To grow or to defend: How plants decide
2. Competition in a rough neighborhood: Plant success in a desert environment
3. Meloidogyne mali: A new invasive plant parasitic nematode in Europe
4. Genetic discovery points the way to much bigger yields in tomato, other flowering food plants
5. Combination of cell transplantation and gene therapy for Alzheimers disease
6. Study offers clues to how plants evolved to cope with cold
7. Researchers create largest evolutionary timetree of land plants to investigate traits that permit survival in cold climates
8. Study: Some plants may not adapt quickly to future climate change
9. A gluttonous plant reveals how its cellular power plant devours foreign DNA
10. Enlisting cells protein recycling machinery to regulate plant products
11. The origin of flowers: DNA of storied plant provides insight into the evolution of flowering plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:3/30/2017)... 2017  On April 6-7, 2017, Sequencing.com will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... ... The AMA is happy to announce that $48,000 in scholarships will be awarded ... created through funds donated by model aviation organizations and individuals, AMA members, and a ... Committee, which is made up of model aviation pilots and enthusiasts. The committee evaluates ...
(Date:4/20/2017)... , April 20, 2017  Eli Lilly and Company ... data evaluating galcanezumab for the prevention of migraine at ... will take place April 22-28, 2017, in ... four abstracts at AAN, including safety and patient outcomes ... associated with a reduction in monthly migraine headache days ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... for advanced technology applications, announced today that Chief Executive Officer (CEO) Debbie Gustafson ... SEMI is the global industry association connecting the electronics manufacturing supply chain. ...
(Date:4/20/2017)... 2017 For today, Stock-Callers.com redirects investors, ... development and clinical research aimed at treating diseases and medical ... Keryx Biopharmaceuticals Inc. (NASDAQ: KERX), Kite Pharma Inc. (NASDAQ: KITE), ... can access our complimentary research reports on these stocks now ... http://stock-callers.com/registration ...
Breaking Biology Technology: