Navigation Links
Plant used in Chinese medicine fights chronic pain
Date:1/2/2014

A plant used for centuries as a pain reliever in Chinese medicine may be just what the doctor ordered, especially when it comes to chronic pain. A key pain-relieving ingredient is a compound known as dehydrocorybulbine (DHCB) found in the roots of the flowering plant Corydalis, a member of the poppy family, according to researchers who report their findings in the Cell Press journal Current Biology on January 2.

"Our study reports the discovery of a new natural product that can relieve pain," says Olivier Civelli of the University of California, Irvine. "This analgesic acts in animal assays against the three types of pain that afflict humans, including acute, inflammatory, and neuropathic or chronic pain."

Civelli, along with Xinmiao Liang, made the discovery as part of the "herbalome" project, an effort to catalogue all of the chemical components of traditional Chinese medicine. The Corydalis plants that were the focus of the new study grow mainly in central eastern China, where underground tubers are harvested, ground, and boiled in hot vinegar. Those concoctions are often prescribed to treat pain, including headaches and back pain.

The researchers went looking for compounds in Corydalis that appeared likely to act in a manner similar to morphine. "We landed on DHCB but rapidly found that it acts not through the morphine receptor but through other receptors, in particular one that binds dopamine," Civelli explains. The discovery adds to earlier evidence showing that the dopamine D2 receptor plays a role in pain sensation.

While Corydalis extracts or isolated DHCB work against all types of pain, they hold special promise for those who suffer with persistent, low-level chronic pain. For one thing, DHCB doesn't appear to lose effectiveness with time in the way that traditional opiate drugs do.

"We have good pain medications for acute pain: codeine or morphine, for example," Civelli
'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. To grow or to defend: How plants decide
2. Competition in a rough neighborhood: Plant success in a desert environment
3. Meloidogyne mali: A new invasive plant parasitic nematode in Europe
4. Genetic discovery points the way to much bigger yields in tomato, other flowering food plants
5. Combination of cell transplantation and gene therapy for Alzheimers disease
6. Study offers clues to how plants evolved to cope with cold
7. Researchers create largest evolutionary timetree of land plants to investigate traits that permit survival in cold climates
8. Study: Some plants may not adapt quickly to future climate change
9. A gluttonous plant reveals how its cellular power plant devours foreign DNA
10. Enlisting cells protein recycling machinery to regulate plant products
11. The origin of flowers: DNA of storied plant provides insight into the evolution of flowering plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... . Why do ... to reproduce? And why are there two sexes anyway? These ... of the research journal Molecular Human Reproduction published ... Bielefeld University Bielefeld has compiled this special issue on sperm ... to copulate with several males in quick succession – chimpanzees ...
(Date:10/17/2014)... German . ... When treating overdoses, doctors are often limited to supportive therapy ... is a combination of drugs involved. So what can be ... grandmother,s pills? ETH professor Jean-Christophe Leroux from the Institute of ... to this question. "The task was to develop an agent ...
(Date:10/16/2014)... at William and Mary,s Virginia Institute of Marine ... the Environmental Protection Agency to identify the streams ... to develop tools to help local governments and ... depends critically on a dataset of tidal-marsh observations ... Only with this historical baseline can today,s researchers ...
Breaking Biology News(10 mins):Sperm wars 2Emergency aid for overdoses 2Emergency aid for overdoses 3EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3
... weaker as they age and then die, but that,s not the ... of aging at all. These are among the findings in ... this week. The study compares the aging patterns of humans ... about aging and what it should be like," said Pedro F. ...
... release is available in French . ... by Canadian researchers may pave the way for more effective treatment ... ETMR/ETANTR. The tumour, which is seen only in children under four, ... a new model for how this brain tumour develops and suggests ...
... the science behind pain, from a simple "ouch" to the ... But now, researchers are reporting a promising step toward studying ... Journal of the American Chemical Society , scientists describe the ... that could result in better ways to relieve pain and ...
Cached Biology News:Not all species age the same; humans may be outliers 2Canadian researchers lead groundbreaking discovery in deadly childhood cancer 2Canadian researchers lead groundbreaking discovery in deadly childhood cancer 3
(Date:10/20/2014)... 20, 2014 Convey Computer , ... team from Iowa State University won first place in ... a Convey HC-2ex, the team’s solution achieved the highest ... than the second place finisher. , Experts from all ... the month long challenge, using a variety of design ...
(Date:10/20/2014)... Inc. (NASDAQ: GNVC ) today announced the retirement ... of directors effective on October 24, 2014.   Dr. Horovitz joined ... chairman from June 2006 to November 2013.  During his tenure, ... Audit Committees of the board.  "We deeply ... to GenVec, and its stockholders," said Wayne T. Hockmeyer ...
(Date:10/20/2014)... OR (PRWEB) October 20, 2014 Local ... participate in an investigational study of donor stem cells ... in stem cell therapy and has performed clinical stem ... this study is to determine if a single injection ... affected joints can help reduce pain and inflammation in ...
(Date:10/19/2014)... 19, 2014 The Asia-Pacific Bromine ... in Asia-Pacific with analysis and forecast of revenue. ... Pacific Bromine Market report, to get an idea ... a glimpse of the segmentation in the Asia-Pacific ... and figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , ...
Breaking Biology Technology:Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3
... Strand, founder of StrandWare Inc., has established a ... located in Eau Claire, provides services to companies ... , ,To promote his new company, Strand is ... of clients through March 17, 2003. Charging only ...
... a leading developer of K-12 software solutions for ... recently announced their online, ASP software that streamlines ... monitors the progress of children with disabilities. ... Wisconsin school districts during 2003, provides special education ...
... looks as if Small Tree Communications might be ... former Cray and SGI employees to brave the market and ... Minn.-based business, with ties to legacy Chippewa Valley computer companies, ... for Apple Computers enterprise customers who need enhanced networking for ...
Cached Biology Technology:Former SGI/Cray Team Develops Products for G5 Platform 2Former SGI/Cray Team Develops Products for G5 Platform 3
, Premium quality synthesis and purification , You provide the sequence, we'll do the rest , Rigorous quality control , Your choice of purification method, amount and format , Available annealed...
... service provides the premium quality siRNAs you ... siRNAs can be readily ordered online by ... or by providing the sense and antisense ... Silencer Validated and Silencer ...
... custom siRNA service provides the premium quality ... research. Custom siRNAs can be readily ordered ... target sequence, or by providing the sense ... Ambion's Silencer Validated and Silencer Pre-designed siRNAs, ...
Human TGF-beta RIIb Affinity Purified Polyclonal Ab...
Biology Products: