Navigation Links
Placental precursor stem cells require testosterone-free environment to survive
Date:10/29/2009

Tampa, Fla. (Oct. 29, 2009) Trophoblast stem cells (TSCs), cells found in the layer of peripheral embryonic stem cells from which the placenta is formed, are thought to exhibit "immune privilege" that aids cell survivability and is potentially beneficial for cell and gene therapies. Further, the survivability of TSCs has been thought to require the presence of ovarian hormones. However, none of these assumptions has ever been verified. This study, published in the current issue of the journal Cell Transplantation (18:7) - now freely available on-line at http://www.ingentaconnect.com/content/cog/ct - has demonstrated that it is the absence of male hormones, rather than the presence of female hormones, that allows extended transplanted cell survivability.

"Questioning whether a female hormonal environment is one of the physiological requirements for ectopic TSC survival, we surmised that a partially immune-privileged site other than the uterus might also allow TSCs to survive and exert a protective action on other nearby cells, enabling the latter to survive in locations where they normally could not," said Dr. Bert Binas, co-author of the study.

When the research team injected the livers of both male and female mice with TSCs, the cells survived in female animal livers but did not survive in male animal livers.

"This was not unexpected, given the natural uterine environment for TSCs," said Dr. Binas. "However, castration of the male mice abolished the sex hormone difference and the livers of the castrated male mice provided a perfect environment for the TSCs."

The researchers concluded that the presence of male hormones was toxic for the injected TSCs. The injected TSCs survived for three months with little if any proliferation, regardless of their immunological compatibility, but were dependent on a non-male hormonal environment in castrated male mice.

The TSCs were also found to promote survival of another cell type when transplanted together, suggesting that these cells may be able to modify their local environment and enhance the survival of co-transplanted cells. Thus a new "stem cell based trophoblastic approach" to therapeutic cell transplantation may prove to be beneficial.

"Our model provides a starting point for systematically assessing the hormonal and other physiological requirements for trophoblast cells in vivo," concludes Dr. Binas and his colleagues.

This study, for the first time, demonstrates that long term survival of trophoblast cells in the absence of ovarian hormones is possible.

"These are exciting results and clearly show that the relationship of stem cells with the host or transplant recipient includes a complex interaction between the 'seed and the soil'," said section editor Dr. Stephen Strom, professor in the Division of Cellular and Molecular Pathology at the University of Pittsburgh. "In the case described here, the "soil" or the natural female environment free of male hormones is an appropriate and supportive environment for TSCs, whereas, the presence of the male hormones proved quite unfavorable for the sustained engraftment of the cells.The good part is that this paper demonstrates that cells such as TSCs confer immunoprotection to another cell type when co-transplanted with the TSCs. However this benefit is only extended to female recipients - males need not apply".


'/>"/>

Contact: Bert Binas
bbinas@hanyang.ac.kr
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Vitamin D found to fight placental infection
2. Fate in fly sensory organ precursor cells could explain human immune disorder
3. Peripheral nerve repair with fat precursor cells led to wider nerves and less muscle atrophy
4. Slipper-shaped blood cells
5. Chemosensitivity of cancer cells depends on their protein dependency
6. Boston University scientists first to see RNA network in live bacterial cells
7. Synthetic cells shed biological insights while delivering battery power
8. Growing cartilage from stem cells
9. Checkered history of mother and daughter cells explains cell cycle differences
10. Small mechanical forces have big impact on embryonic stem cells
11. A major step in making better stem cells from adult tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... 2017  Catholic Health Services (CHS) has been ... (HIMSS) Analytics for achieving Stage 6 on the ... In addition, CHS previously earned a place in ... electronic medical record (EMR). "HIMSS Analytics ... EMR usage in an outpatient setting.  This recognition ...
(Date:3/23/2017)... , Mar. 23, 2017 Research and Markets ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 8.8% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
(Date:3/20/2017)... At this year,s CeBIT Chancellor Dr. Angela Merkel ... came to the DERMALOG stand together with the Japanese Prime Minster Shinzo ... At the largest German biometrics company the two government leaders could see ... as well as DERMALOGĀ“s multi-biometrics system.   Continue ... ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... April 25, 2017 , ... Franz Inc ., ... development tools, and market leader for Semantic Graph Database technology, today ... within the most effective system for developing and deploying applications to solve the ...
(Date:4/25/2017)... GREENVILLE, SC (PRWEB) , ... April 25, 2017 ... ... SC-based Piedmont Physical Medicine & Rehabilitation, P.A. , proudly announced today that ... will officially commence his duties on May 15, 2017. , Dr. Terzella completed ...
(Date:4/24/2017)... ... April 24, 2017 , ... It is well established that ... the broad application of this cellular target engagement concept to drug discovery has ... thermal stabilization assays are valuable methods for particular applications, but they can require ...
(Date:4/21/2017)... ... April 21, 2017 , ... Having worked on the design of ... pleased to introduce it to top lab design architects from around the country at ... VP of Industrial Design and Engineering Greg Casey will be at the show, where ...
Breaking Biology Technology: