Navigation Links
Pivotal discoveries in age-related macular degeneration
Date:2/6/2011

or part of the "dark" genome. The discovery of Alu's toxicity and its control by Dicer should prove of great interest to other researchers in the biological sciences, Ambati says.

Ambati's team developed two potential therapies aimed at preventing geographic atrophy and demonstrated the efficacy of both approaches using laboratory models. The first involves increasing Dicer levels in the retina by "over-expressing" the enzyme. The second involves blocking Alu RNA using an "anti-sense" drug that binds and degrades this toxic substance. UK has filed patent applications for both technologies, and Ambati's group is preparing to start clinical trials by the end of this year.

Response from the scientific community has been enthusiastic.

"These findings provide important new clues on the biological basis of geographic atrophy and may provide avenues for intervention through preventing toxic accumulation of abnormal RNA products," said Dr. Paul Sieving, director of the National Eye Institute.

"Ambati's latest research provides important mechanistic insights in geographic atrophy, and identification of this novel pathway may result in new therapeutic targets for a major cause of blindness," said Dr. Napoleone Ferrara, a member of the National Academy of Sciences and Lasker-DeBakey awardee who is a researcher at Genentech.

This work has "widespread implications" for future study, said Dr. Stephen J. Ryan, president of the Doheny Eye Institute and member of the Institute of Medicine.

"The authors have opened an important line of research with real possibilities for future therapeutic intervention for patients with geographic atrophy," Ryan said.


'/>"/>

Contact: Keith L. Hautala
keith.hautala@uky.edu
859-257-1754 x231
University of Kentucky
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Onconova announces FDA agreement of a SPA for a pivotal phase 3 trial of Estybon in MDS
2. Volcanoes played pivotal role in ancient ice age, mass extinction
3. New discoveries improve climate models
4. New discoveries make it harder for HIV to hide from drugs
5. UTHealth discoveries shed more light on deadly thoracic aortic disease
6. New discoveries in North Americas Great Plains bring ammonites to life
7. Nanoparticle scientist speaks on new discoveries at Goldschmidt Conference
8. Charles Drew University researcher will be honored for discoveries
9. Society of Interventional Radiology highlights medical advances, new discoveries
10. New discoveries could improve climate projections
11. UCR plant scientists research spawns new discoveries showing how crops survive drought
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pivotal discoveries in age-related macular degeneration
(Date:8/28/2014)... traditional cigarettes, but still release toxins into the ... , Scientists studying secondhand smoke from e-cigarettes discovered ... particles, with close-to-zero exposure to organic carcinogens. However, ... second-hand e-cigarette smoke were found to be significantly ... of polycyclic aromatic hydrocarbons cancer-causing organic compounds ...
(Date:8/28/2014)... 2014) Researchers at the University of Minnesota have ... (FSHD) to be used for muscle regeneration research as ... for FSHD. , The research is published in the ... , There is no treatment for FSHD, which is ... of muscular dystrophy. FSHD is an unusual genetic disorder ...
(Date:8/28/2014)... the developmental on-off switch for Streptomyces , a ... of the world,s naturally derived antibiotic medicines. , ... is possible to manipulate this switch to make nature,s ... August 28 in Cell , found that a ... a larger protein called BldD ultimately controls whether a ...
Breaking Biology News(10 mins):Second-hand e-cig smoke compared to regular cigarette smoke 2UMN researchers find animal model for understudied type of muscular dystrophy 2Small molecule acts as on-off switch for nature's antibiotic factory 2Small molecule acts as on-off switch for nature's antibiotic factory 3
... of Sciences will honor 15 individuals with awards in recognition ... fields spanning the physical, biological, and medical sciences. The recipients ... Professor at the Pennsylvania State University, is the recipient of ... being honored for his innovative studies of the flow of ...
... applications as suspensions, engineers need to understand how to ... to understand DST and calculate when it will occur ... from consumer products to cement, a range of industries ... For simple liquids, such as water or ...
... and update of a controversial 20-year-old theory of consciousness ... that consciousness derives from deeper level, finer scale activities ... in "microtubules" inside brain neurons corroborates this theory, according ... They suggest that EEG rhythms (brain waves) also derive ...
Cached Biology News:Academy honors 15 for major contributions to science 2Academy honors 15 for major contributions to science 3Academy honors 15 for major contributions to science 4Academy honors 15 for major contributions to science 5CCNY team models sudden thickening of complex fluids 2Discovery of quantum vibrations in 'microtubules' corroborates theory of consciousness 2Discovery of quantum vibrations in 'microtubules' corroborates theory of consciousness 3
(Date:8/29/2014)... Boston, MA (PRWEB) August 29, 2014 Due ... (FRC) last week, the Adult Stem Cell Technology Center, ... donations to support stem cell therapy research that might benefit ... adult stem cells for new stem cell technologies and therapeutic ... ALS Ice Bucket Challenge donors who wish not ...
(Date:8/29/2014)... San Antonio, TX (PRWEB) August 29, 2014 ... 9001:2008 and ISO 13485:2003 certified, GAMP® 5 compliant ... been awarded an international Phase II clinical trial ... non-Hodgkin’s lymphoma. , Throughout this trial, Intrinsic Imaging ... but not limited to, protocol and charter development, ...
(Date:8/28/2014)... Best Sanitizers, Inc., a leader in ... industry, is asking industry professionals to prepare for fall ... E2 soap they’re currently using to the Best Sanitizers’ ... Hand hygiene is critical to fighting cross-contamination and the ... key criteria are identified to evaluate the effectiveness of ...
(Date:8/28/2014)... “This kit has an improved extraction efficiency ... to 150 ppb,” said Mark Tess, PhD, Mycotoxin Product Manager ... plant owners and USDA-GIPSA inspection agencies that have a need ... take place in a matter of minutes with nothing but ... the feed and grain before accepting it, but they no ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2
... Production of cellulosic ethanol in Scotland, S.D. to start in Q4 ... ... 2008 -- At the American Coalition for Ethanol conference, http://www.poet.com ... million pilot-scale cellulosic ethanol production facility later this year. The pilot ...
... 40.8% to $11.6 million ... Net Income increased 118.8% to $2.5 million, ... Medicine,Corporation (OTC Bulletin Board: CHME) ("China Medicine" or ... and over-the-counter,pharmaceuticals, traditional Chinese medicines ("TCM"), nutritional and,dietary-supplements, ...
... DuPont Tate & Lyle Bio Products today announced that its ... as a natural ingredient by ECOCERT®, one of the leading ... ... Loudon, TN August 13, 2008 –- http://www.duponttateandlyle.com/ ...
Cached Biology Technology:POET Announces That Cellulosic Ethanol Pilot Facility Will Be Operational This Year 2POET Announces That Cellulosic Ethanol Pilot Facility Will Be Operational This Year 3China Medicine Announces Strong Second Quarter 2008 Results 2China Medicine Announces Strong Second Quarter 2008 Results 3China Medicine Announces Strong Second Quarter 2008 Results 4China Medicine Announces Strong Second Quarter 2008 Results 5China Medicine Announces Strong Second Quarter 2008 Results 6China Medicine Announces Strong Second Quarter 2008 Results 7China Medicine Announces Strong Second Quarter 2008 Results 8China Medicine Announces Strong Second Quarter 2008 Results 9China Medicine Announces Strong Second Quarter 2008 Results 10China Medicine Announces Strong Second Quarter 2008 Results 11Zemea Propanediol Approved as a Natural Ingredient by ECOCERT 2Zemea Propanediol Approved as a Natural Ingredient by ECOCERT 3
... Series are a line of pre-integrated ... fast and reliable automated solutions to ... "automation-friendly" building blocks, Caliper has created ... than conventional approaches, take up little ...
... 2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one White solid. ... A brain-permeable and water soluble pyrimidinone compound ... + -competitive inhibitor of PARP (IC 50 ... for rhPARP1 and rmPARP2, respectively) with little ...
...
... The Mini-PROTEAN II multiscreen apparatus is used ... 7 cm) gels. The apparatus can screen up ... to cut the blot into strips. The apparatus ... templates that accommodate one or two 8 x ...
Biology Products: