Navigation Links
Pittsburgh scientists identify human source of stem cells with potential to repair muscle
Date:9/4/2007

For the first time, scientists at Children's Hospital of Pittsburgh of UPMC have discovered a unique population of adult stem cells derived from human muscle that could be used to treat muscle injuries and diseases such as heart attack and muscular dystrophy.

In a study using human muscle tissue, scientists in Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Pault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell-sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cells.

These characteristics may make them ideally suited as a potential therapy for muscle injuries and diseases, according to Drs. Huard and P ault. Results of the study are published in the September issue of the journal Nature Biotechnology.

"Finding this population of stem cells in a human source represents a major breakthrough for us because it brings us much closer to a clinical application of this therapy," said Dr. Huard, the Henry J. Mankin Professor and vice chair for Research in the Department of Orthopaedic Surgery at the University of Pittsburgh School of Medicine. "To make this available as a therapy, we would take a muscle biopsy from a patient with a muscle injury or disease, remove the myoendothelial cells and treat the cells in the lab. The stem cells would then be re-injected into the patient to repair the muscle damage. Because this is an autologous transplant, meaning from the patient to himself, there is not the risk of rejection you would have if you took the stem cells from another source."

Working in dystrophic mice while searching for a cure for Duchenne muscular dystrophy (DMD), Dr. Huard's laboratory team first identified a unique population of muscle-derived stem cells with the ability to repair muscle 8 years ago.

Dr. Pault, a professor in t
'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
2. Pittsburgh researchers discover that certain chemicals in the blood may indicate brain injury
3. Whats in the water? Estrogenic activity documented in fish caught in Pittsburghs rivers
4. The sturdier sex? -- Study by Pittsburgh scientists finds female stem cells work better
5. University of Pittsburgh School of Medicine researchers develop off-the-shelf vascular grafts
6. Wisconsin scientists grow critical nerve cells
7. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
8. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
9. UAB scientists discover the origin of a mysterious physical force
10. Fox Chase Cancer Center scientists identify immune-system mutation
11. Scientists Replicate Hepatitis C Virus in Laboratory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... LaunchKey , the first decentralized mobile authentication and authorization ... era, today announced the close of $3 million in ... Metamorphic Ventures with participation from ENIAC Ventures, Crosslink Capital, ... has raised $4 million to date, and will use ...
(Date:12/17/2014)... , Dec. 16, 2014 Research and Markets ... the "Global Chemical Sensor Market 2015-2019" report ... One major trend upcoming in this ... biomedical applications. Chemical sensors help in recording of patient ...
(Date:12/11/2014)... blood pressure plays a role in human health has been ... for high blood pressure – was first described as a ... used in measuring blood pressure was invented in 1896. ... its triggers and its effects. In fact, recent findings have ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... in German . , X-ray microscopy ... obtain sharp images instrument and sample must stay absolutely ... Researchers at the Technische Universitaet Muenchen and the Paul ... method that relaxes these hard restrictions. Even fluctuations in ...
... But it,s a dog-eat-dog world, and with the exception of ... this vicious reality, a tiny insect that eats plants has ... its beetle predator. The pest is called the ... recent years has caused immeasurable loss of biodiversity. Cycads belong ...
... closer look at personalized or point-of-care healthcare was ... India organized and chaired by NJIT Distinguished Professor ... and Biology Society (EMBS) International Special Topic Conference ... world, focused on topics ranging from 21st century ...
Cached Biology News:Improved X-ray microscopic imaging 2Pest uses plant hairs for protection 2Personalized health care will revolutionize 21st century medicine, says NJIT professor 2Personalized health care will revolutionize 21st century medicine, says NJIT professor 3
(Date:12/24/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ) ... ) has submitted a pre-market approval application to the ... of Medtronic,s SynchroMed ® II implantable drug infusion ... United Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
(Date:12/24/2014)... December 23, 2014 “Preparative & ... HPLC, Flash), Consumables (Columns, Solvents, Buffers, Valves, Guages, ... & Agriculture) - Forecasts to 2019” provides a ... opportunities, current market trends, and strategies impacting the ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 Earlier this year ... Sherley, director of the Adult Stem Cell Technology Center, LLC ... under appreciated unique property of adult tissue stem cells. ... the Past, Important for the Future,” embodied the essence of ...
Breaking Biology Technology:United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4
... Abbott (NYSE: ABT ),will present at the 26th ... Thomas C. Freyman, executive vice president, finance and,chief financial ... at,11:00 a.m. Central time., A live audio webcast ... Web site at http://www.abbottinvestor.com . An,archived edition of ...
... Solstice Neurosciences, Inc.,("Solstice") announced the appointment of Dennis ... will also continue to serve as Chairman to ... specialty pharmaceutical industry experience,and expertise to Solstice that ... for growth as the company continues to broaden,its ...
... & Forbes Holdings Inc.,announced today that Dr. Eric ... also serves as Chief Executive Officer of SIGA ... Science Board (NBSB). The,NBSB will provide expert advice ... technical and other matters of special interest to ...
Cached Biology Technology:Dennis L. Smith Appointed President and Chief Executive Officer of Solstice Neurosciences, Inc. 2Department of Health & Human Services Names Dr. Eric Rose to National Biodefense Science Board 2
... Radiochemical Purity is >95%NEN Radiolabeled Ligands\n\nReceptor-related ... continual availability of new radiolabeled ligands selected ... offers a wide range of products and ... including over 400 state-of-the-art radioligands. If you ...
... system provides excellent performance with isocratic ... suppression, and column heater all standard, ... sensitivity and stability. The vacuum degas ... trace-level work. Operate in manual or ...
... The DMW143 taken from the SMZ line is ... of production and testing. It is available with ... (FBGG) or a space-saving compact base (N2GG). This ... TV and a projector all at the same ...
... data analysis , Automatic grid, subgrid and spot ... template assignment , ... Extensive background and signal options to optimize, ... results , Characterize ...
Biology Products: