Navigation Links
Pittsburgh scientists identify human source of stem cells with potential to repair muscle
Date:9/4/2007

For the first time, scientists at Children's Hospital of Pittsburgh of UPMC have discovered a unique population of adult stem cells derived from human muscle that could be used to treat muscle injuries and diseases such as heart attack and muscular dystrophy.

In a study using human muscle tissue, scientists in Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Pault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell-sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cells.

These characteristics may make them ideally suited as a potential therapy for muscle injuries and diseases, according to Drs. Huard and P ault. Results of the study are published in the September issue of the journal Nature Biotechnology.

"Finding this population of stem cells in a human source represents a major breakthrough for us because it brings us much closer to a clinical application of this therapy," said Dr. Huard, the Henry J. Mankin Professor and vice chair for Research in the Department of Orthopaedic Surgery at the University of Pittsburgh School of Medicine. "To make this available as a therapy, we would take a muscle biopsy from a patient with a muscle injury or disease, remove the myoendothelial cells and treat the cells in the lab. The stem cells would then be re-injected into the patient to repair the muscle damage. Because this is an autologous transplant, meaning from the patient to himself, there is not the risk of rejection you would have if you took the stem cells from another source."

Working in dystrophic mice while searching for a cure for Duchenne muscular dystrophy (DMD), Dr. Huard's laboratory team first identified a unique population of muscle-derived stem cells with the ability to repair muscle 8 years ago.

Dr. Pault, a professor in t
'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
2. Pittsburgh researchers discover that certain chemicals in the blood may indicate brain injury
3. Whats in the water? Estrogenic activity documented in fish caught in Pittsburghs rivers
4. The sturdier sex? -- Study by Pittsburgh scientists finds female stem cells work better
5. University of Pittsburgh School of Medicine researchers develop off-the-shelf vascular grafts
6. Wisconsin scientists grow critical nerve cells
7. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
8. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
9. UAB scientists discover the origin of a mysterious physical force
10. Fox Chase Cancer Center scientists identify immune-system mutation
11. Scientists Replicate Hepatitis C Virus in Laboratory

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2009)...wire/ -- Glencoe Software, Inc., the commercial ar...ium ( http://openmicroscopy.org ), is proud to a...y of Cell Biology,s exciting new project titled "T...ded a $2.5M stimulus grant through the National In...gram, as part of the American Reinvestment and Rec...
(Date:11/3/2009)...ultimate loner of the ocean, cruising thousands of...rs has discovered that the sharks have maintained ...ens of thousands of years the white sharks in the ...es into a population genetically distinct from sha...a large, highly mobile species," said Salvador Jor...
(Date:11/3/2009)...women are as much as 28 percent less likely to bec...rding to research that earned a Michigan State Uni...gs by Barbara Luke, a researcher in the MSU Colleg...necology and Reproductive Biology, focused on data...e technology. , Luke,s findings, which also can ...
Breaking Biology News(10 mins):Glencoe Software to Support the ASCB 'Stimulus Grant' to Build Virtual Image Library of the Cell 2Tags reveal white sharks have neighborhoods in the north Pacific, say Stanford researchers 2Tags reveal white sharks have neighborhoods in the north Pacific, say Stanford researchers 3Tags reveal white sharks have neighborhoods in the north Pacific, say Stanford researchers 4MSU researcher: Obesity significantly cuts odds of successful pregnancy 2Advance in Bowel Cancer Test Research 4533 1Advance in Bowel Cancer Test Research 4533 2QIO Support Accelerates Hospital Improvement in Heart Care Researchers Find 47853 1QIO Support Accelerates Hospital Improvement in Heart Care Researchers Find 47853 2Two Ways to Tackle Tuberculosis 47849 1Two Ways to Tackle Tuberculosis 47849 2Two Ways to Tackle Tuberculosis 47849 3
...from Université Laval’s Faculty of Medicine have s...cells extracted from adult human skin. This is the...ifferentiation has been achieved from human skin, ...rthod. This breakthrough could eventually lead to ...generative illnesses such as Parkinson’s disease. ...
...from the NIOZ Royal Netherlands Institute for Sea ...mperature record for tropical central Africa over ...n with a German colleague from the University of B...thod to reconstruct the history of land temperatur.... They applied the method to a marine sediment cor...
...on,s under stress or injured, the adrenal gland re...ns to normal. But the hormone,s effects are many a...tem, helping create memories with short-term expos...for too long. Given the variety of its effects,und...oducing medications that can alter its production....
Other Biology News:Scientists produce neurons from human skin 2Microfossils unravel climate history of tropical Africa 2Scientists unravel clue in cortisol production 2
(Date:11/6/2009)...alif., Nov. 6 ,, 3...fer of Qutenza(TM) E.U. Marketing Authorization to...ogress in commercial readiness activities Expande...ctor, Marketing; and Director, Commercial Operatio...ctor and Audit Committee chairman , Upcomin...
(Date:11/6/2009)... The agenda for Arrowhead’s 2010 Pers...s set to take place on February 22-24, 2010 in Phi...onference we will highlight key issues in forming ... their experiences. , Min...a for Arrowhead’s 2010 Personalized Medicin...
(Date:11/5/2009)...N.J., Nov. 5 DSM Pharmaceutical Pr...uring alliance with Galenix, Saint Jean D,Illac, F...scale manufacturing partner for Galenix commercial... will collaborate on business development opportun...ies, based on the strength of Galenix in drug prod...
(Date:11/5/2009)... Nov. 5 Transgenomic, In...ncial results for the quarter ended September 30, ...d in the tables that follow. ,, Third Quarter ...6,000 or $0.01 per share for the third quarter of ...1 per share for the third quarter of 2008. ,, ...
Breaking Biology Technology:NeurogesX Reports Third Quarter 2009 Results 2NeurogesX Reports Third Quarter 2009 Results 3NeurogesX Reports Third Quarter 2009 Results 4NeurogesX Reports Third Quarter 2009 Results 5NeurogesX Reports Third Quarter 2009 Results 6NeurogesX Reports Third Quarter 2009 Results 7NeurogesX Reports Third Quarter 2009 Results 8NeurogesX Reports Third Quarter 2009 Results 9NeurogesX Reports Third Quarter 2009 Results 10Leaders in Biopharma and Molecular Diagnostics to Discuss Key Issues and Opportunities in Forming Partnerships at 2010 Personalized Medicine Partnerships Conference 2Leaders in Biopharma and Molecular Diagnostics to Discuss Key Issues and Opportunities in Forming Partnerships at 2010 Personalized Medicine Partnerships Conference 3DSM Pharmaceutical Products Forms Manufacturing Alliance With Galenix 2DSM Pharmaceutical Products Forms Manufacturing Alliance With Galenix 3Transgenomic, Inc. Reports Third Quarter 2009 Results 2Transgenomic, Inc. Reports Third Quarter 2009 Results 3Transgenomic, Inc. Reports Third Quarter 2009 Results 4Transgenomic, Inc. Reports Third Quarter 2009 Results 5Transgenomic, Inc. Reports Third Quarter 2009 Results 6Transgenomic, Inc. Reports Third Quarter 2009 Results 7
...IVUS, Inc. (Nasdaq: VVUS ), a biopharmaceutica...ialization of novel therapeutic products, today re...e first quarter ended March 31, 2009. , , Firs...ssuance of Key European Patent for Qnexa - In Jan...ffice had granted a patent for Qnexa. The European...
...al Arts Alliance , , BATON ROUGE, La., May 11 Th...ort, for the second year in a row, Louisiana State...n for Students (BIOS) program with scholarships an...n Foundation Digital Arts Fellows will use video c... along to future program participants. Films from ...
..., Inc. (Pink Sheets: NNLX) is pleased to announce ... evaluate and target research and development effo... the company with a vastly expanded scope of exper... , Dr. Robert Ollar, NanoLogix cofounder and autho... the NanoLogix Board of Directors to assume the po...
Other Biology Technology:VIVUS Reports First Quarter 2009 Financial Results and Highlights 2VIVUS Reports First Quarter 2009 Financial Results and Highlights 3VIVUS Reports First Quarter 2009 Financial Results and Highlights 4VIVUS Reports First Quarter 2009 Financial Results and Highlights 5VIVUS Reports First Quarter 2009 Financial Results and Highlights 6VIVUS Reports First Quarter 2009 Financial Results and Highlights 7Pearson Foundation Supports Incoming LSU Biology Students With 21st Century Learning Tools 2Pearson Foundation Supports Incoming LSU Biology Students With 21st Century Learning Tools 3A Global View: NanoLogix Creates Science Advisory Board 2A Global View: NanoLogix Creates Science Advisory Board 3A Global View: NanoLogix Creates Science Advisory Board 4A Global View: NanoLogix Creates Science Advisory Board 5
...nal [6331] to Salmonella typhimurium The genus Sa...eae. The genus is composed of Gram-negative bacill...Salmonellae possess 3 major antigens; the "H" or f... antigen (part of the LPS moiety) and the "Vi" or ...
...W4 liquid handling system from Molecular Devices p...l in one instrument. The system handles a variety ...6-, 384- and 1536-welland is the first to handle 1...optimized to dispense from four different channels...
...sodium pyruvate, 50 mg/L streptomycin sulfate, 100...lcium chloride, and magnesium chloride. The use of...is generally attributed to early workers in the fi...f inorganic salts designed to maintain contractili...
Horizontal Laminar Flow Work Station from Terra Universal, Inc.
Biology Products: