Navigation Links
Pittsburgh researchers identify source of multipotent stem cells with broad regenerative potential

In a promising finding for the field of regenerative medicine, stem cell researchers at Children's Hospital of Pittsburgh of UPMC have identified a source of adult stem cells found on the walls of blood vessels with the unlimited potential to differentiate into human tissues such as bone, cartilage and muscle.

The scientists, led by Bruno Pault, PhD, deputy director of the Stem Cell Research Center at Children's Hospital, identified cells known as pericytes that are multipotent, meaning they have broad developmental potential. Pericytes are found on the walls of small blood vessels such as capillaries and microvessels throughout the body and have the potential to be extracted and grown into many types of tissues, according to the study.

"This finding marks the first direct evidence of the source of multipotent adult stem cells known as mesenchymal stem cells. We believe pericytes represent one of the most promising sources of multipotent stem cells that scientists have been searching for in the quest to make regenerative medicine possible," Dr. Pault said. "The encouraging aspect of this source is that blood vessels are the one structure that all tissues in the human body have in common. These cells can be extracted easily and painlessly from convenient sources such as fat tissue, dental pulp, umbilical cord and placental tissue, then grown in culture to large numbers and, possibly, re-injected into the patient to heal a broken bone, a failing joint or an injured muscle."

Results of the study are published in the September issue of the journal Cell Stem Cell.

In their laboratory in the John G. Rangos Sr. Research Center, researchers were able to identify pericytes in all human tissues they analyzed, including muscle, fat, pancreas, placenta and many other samples. Through purification in the lab, these pericytes could then be coaxed into becoming whatever type of tissue the scientists desired. For instance, the researchers took pericytes from the pancreas and then reinjected them into an injured muscle. The cells immediately began regenerating muscle tissue.


Contact: Marc Lukasiak
Children's Hospital of Pittsburgh

Related biology news :

1. Womens health-related scientific findings presented by University of Pittsburgh researchers
2. University of Pittsburgh cardiologists identify new cardiac arrest gene
3. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
4. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
5. U of M researchers identify gene linked to common ailment in labrador retrievers
6. Friendly bacteria protect against type 1 diabetes, Yale researchers find
7. Using novel tool, UD researchers dig through cell trash and find treasure
8. More than skin deep: Theres no such thing as a safe suntan, researchers warn
9. Flatworm helps researchers study stem cells and cancer
10. Giant grass offers clues to growing corn in cooler climes, researchers report
11. Childrens Hospital researchers identify genetic mutation that may predict organ rejection
Post Your Comments:
(Date:10/6/2015)... 6, 2015  Maverix Biomics, Inc., a leading ... its software portfolio with the debut of its ... expression in eukaryotes. The software is integrated into ... genomic analysis solution that leverages proven open-source algorithms ... sequencing efforts. Garry Nolan,s laboratory ...
(Date:9/30/2015)... , Sept. 30, 2015  With nearly 300,000 ... number of new SCIs estimated to reach 12,500 annually, ... Southern California Resource Services for Independent Living (SCRS-IL) ... in California opening doors to ... of programs and services, notably assistive technology services and ...
(Date:9/29/2015)... , Sept. 29, 2015  iDAvatars is excited to be ... its product to market. The official announcement was recently made ... event in San Francisco , where ... powered by IBM Watson. "It is both an ... 100 companies to bring to market the cognitive power of ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... ... ... Clinovo recently appointed Jeff Parr and Ed Donaldson to its Business Development Management ... Jeff Parr has spent the past decade providing quality management software and consulting services ... Sciex to name a few. He is based in Salt Lake City, a ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... technologies, announced today that it received de novo clearance from the U.S. Food ... for the ablation of prostate tissue. Sonablate® is the first High Intensity Therapeutic ...
(Date:10/13/2015)... ... October 13, 2015 , ... Proove Biosciences, ... announce their partnership with the Keck Medicine of the University of Southern ... The T.R.O.J.A.N. Study (Therapeutic Evaluation to Research Clinical Objectives Linking Genotypic and Phenotypic ...
(Date:10/13/2015)... Jersey (PRWEB) , ... October 13, 2015 , ... ... enhance the educational opportunities for school age children in the areas of Science, ... for all sectors of the national economy, and the program aims to increase ...
Breaking Biology Technology: