Navigation Links
Pittsburgh researchers identify source of multipotent stem cells with broad regenerative potential
Date:9/22/2008

In a promising finding for the field of regenerative medicine, stem cell researchers at Children's Hospital of Pittsburgh of UPMC have identified a source of adult stem cells found on the walls of blood vessels with the unlimited potential to differentiate into human tissues such as bone, cartilage and muscle.

The scientists, led by Bruno Pault, PhD, deputy director of the Stem Cell Research Center at Children's Hospital, identified cells known as pericytes that are multipotent, meaning they have broad developmental potential. Pericytes are found on the walls of small blood vessels such as capillaries and microvessels throughout the body and have the potential to be extracted and grown into many types of tissues, according to the study.

"This finding marks the first direct evidence of the source of multipotent adult stem cells known as mesenchymal stem cells. We believe pericytes represent one of the most promising sources of multipotent stem cells that scientists have been searching for in the quest to make regenerative medicine possible," Dr. Pault said. "The encouraging aspect of this source is that blood vessels are the one structure that all tissues in the human body have in common. These cells can be extracted easily and painlessly from convenient sources such as fat tissue, dental pulp, umbilical cord and placental tissue, then grown in culture to large numbers and, possibly, re-injected into the patient to heal a broken bone, a failing joint or an injured muscle."

Results of the study are published in the September issue of the journal Cell Stem Cell.

In their laboratory in the John G. Rangos Sr. Research Center, researchers were able to identify pericytes in all human tissues they analyzed, including muscle, fat, pancreas, placenta and many other samples. Through purification in the lab, these pericytes could then be coaxed into becoming whatever type of tissue the scientists desired. For instance, the researchers took pericytes from the pancreas and then reinjected them into an injured muscle. The cells immediately began regenerating muscle tissue.


'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
Source:Eurekalert

Related biology news :

1. Womens health-related scientific findings presented by University of Pittsburgh researchers
2. University of Pittsburgh cardiologists identify new cardiac arrest gene
3. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
4. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
5. U of M researchers identify gene linked to common ailment in labrador retrievers
6. Friendly bacteria protect against type 1 diabetes, Yale researchers find
7. Using novel tool, UD researchers dig through cell trash and find treasure
8. More than skin deep: Theres no such thing as a safe suntan, researchers warn
9. Flatworm helps researchers study stem cells and cancer
10. Giant grass offers clues to growing corn in cooler climes, researchers report
11. Childrens Hospital researchers identify genetic mutation that may predict organ rejection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... India , March 23, 2017 The report "Gesture ... Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, ... at a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/22/2017)... YORK , March 21, 2017 ... Marketing Cloud used by retailers such as 1-800-Flowers ... its platform — Product Recommendations and Replenishment. Using Optimove,s ... give more personalized product and replenishment recommendations to ... but also on predictions of customer intent drawn ...
(Date:3/20/2017)... , March 20, 2017 PMD Healthcare ... personal spirometer and Wellness Management System (WMS), a remote, ... Founded in 2010, PMD Healthcare is a Medical Device, ... a mission dedicated to creating innovative solutions that empower ... With that intent focus, PMD developed the first ever ...
Breaking Biology News(10 mins):
(Date:6/16/2017)... CT (PRWEB) , ... June 16, 2017 , ... ... night’s Entrepreneur Innovation Awards (EIA), held at The LOFT at Chelsea Piers in Stamford. ... project ideas to a panel of judges for an opportunity to secure $10,000 awards ...
(Date:6/15/2017)... ... June 15, 2017 , ... The newest exhibition at the ... creative experimentation and interdisciplinary collaboration. Feature Creep, a solo exhibition by Maximillian Lawrence, ... will be held at EKG, located at 3600 Market Street in Philadelphia, on ...
(Date:6/15/2017)... ... June 15, 2017 , ... Adam Equipment, a ... to assemble a lab workstation. The guide outlines the procedure in four simple ... Eclipse balance, AVT anti-vibration table, OIML/ASTM certified weights, and Adam DU specialized software. ...
(Date:6/14/2017)... , ... June 14, 2017 , ... ... materials for pumps and process equipment, has appointed Andrew Ondish as Territory Sales ... Ondish holds a B.S. degree in Petroleum Engineering from Colorado School of Mines. ...
Breaking Biology Technology: