Navigation Links
Pittsburgh researchers identify source of multipotent stem cells with broad regenerative potential
Date:9/22/2008

In a promising finding for the field of regenerative medicine, stem cell researchers at Children's Hospital of Pittsburgh of UPMC have identified a source of adult stem cells found on the walls of blood vessels with the unlimited potential to differentiate into human tissues such as bone, cartilage and muscle.

The scientists, led by Bruno Pault, PhD, deputy director of the Stem Cell Research Center at Children's Hospital, identified cells known as pericytes that are multipotent, meaning they have broad developmental potential. Pericytes are found on the walls of small blood vessels such as capillaries and microvessels throughout the body and have the potential to be extracted and grown into many types of tissues, according to the study.

"This finding marks the first direct evidence of the source of multipotent adult stem cells known as mesenchymal stem cells. We believe pericytes represent one of the most promising sources of multipotent stem cells that scientists have been searching for in the quest to make regenerative medicine possible," Dr. Pault said. "The encouraging aspect of this source is that blood vessels are the one structure that all tissues in the human body have in common. These cells can be extracted easily and painlessly from convenient sources such as fat tissue, dental pulp, umbilical cord and placental tissue, then grown in culture to large numbers and, possibly, re-injected into the patient to heal a broken bone, a failing joint or an injured muscle."

Results of the study are published in the September issue of the journal Cell Stem Cell.

In their laboratory in the John G. Rangos Sr. Research Center, researchers were able to identify pericytes in all human tissues they analyzed, including muscle, fat, pancreas, placenta and many other samples. Through purification in the lab, these pericytes could then be coaxed into becoming whatever type of tissue the scientists desired. For instance, the researchers took pericytes from the pancreas and then reinjected them into an injured muscle. The cells immediately began regenerating muscle tissue.


'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
Source:Eurekalert

Related biology news :

1. Womens health-related scientific findings presented by University of Pittsburgh researchers
2. University of Pittsburgh cardiologists identify new cardiac arrest gene
3. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
4. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
5. U of M researchers identify gene linked to common ailment in labrador retrievers
6. Friendly bacteria protect against type 1 diabetes, Yale researchers find
7. Using novel tool, UD researchers dig through cell trash and find treasure
8. More than skin deep: Theres no such thing as a safe suntan, researchers warn
9. Flatworm helps researchers study stem cells and cancer
10. Giant grass offers clues to growing corn in cooler climes, researchers report
11. Childrens Hospital researchers identify genetic mutation that may predict organ rejection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a ... most common and aggressive adult brain cancer—announced today the appointments of its first ... charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows are ...
(Date:6/25/2020)... MANSFIELD, Mass. (PRWEB) , ... June 24, 2020 ... ... provider of cloud-based enterprise software and software-driven clinical data services that accelerate drug ... trials for low-dose selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. ...
(Date:6/23/2020)... ... 2020 , ... The field of quantitation of large molecules or proteins has ... area. However, the use of mass spectrometry in this field has gained a lot ... do you choose which approach to use (LBA or MS)?” In many cases, ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... , ... True Terpenes , the leading platform for terpene innovation, research ... research the medical potential of terpenes and the potential entourage effect , where ... is focused on expanding the recently launched line of effects-based terpenes - Terpology ...
(Date:8/7/2020)... ... 06, 2020 , ... VGXI, a highly regarded CDMO supporting ... purchase of greenfield for a new, expanded manufacturing facility. The site is located ... the initial acquisition, with an option to purchase an additional 21 acres for ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
(Date:7/31/2020)... (PRWEB) , ... July 30, ... ... of cloud-based software for the life sciences industry, today announced the release ... platform designed specifically for Medical Science Liaisons (MSLs) and other field medical ...
Breaking Biology Technology: