Navigation Links
Pitt team recreates brain cell networks with new view of activity behind memory formation
Date:5/25/2011

PITTSBURGHUniversity of Pittsburgh researchers have reproduced the brain's complex electrical impulses onto models made of living brain cells that provide an unprecedented view of the neuron activity behind memory formation.

The team fashioned ring-shaped networks of brain cells that were not only capable of transmitting an electrical impulse, but also remained in a state of persistent activity associated with memory formation, said lead researcher Henry Zeringue [zuh-rang], a bioengineering professor in Pitt's Swanson School of Engineering. Magnetic resonance images have suggested that working memories are formed when the cortex, or outer layer of the brain, launches into extended electrical activity after the initial stimulus, Zeringue explained. But the brain's complex structure and the diminutive scale of neural networks mean that observing this activity in real time can be nearly impossible, he added.

The Pitt team, however, was able to generate and prolong this excited state in groups of 40 to 60 brain cells harvested from the hippocampus of ratsthe part of the brain associated with memory formation. In addition, the researchers produced the networks on glass slides that allowed them to observe the cells' interplay. The work was conducted in Zeringue's lab by Pitt bioengineering doctoral student Ashwin Vishwanathan, who most recently reported the work in the Royal Society of Chemistry (UK) journal, Lab on a Chip. Vishwanathan coauthored the paper with Zeringue and Guo-Qiang Bi, a neurobiology professor in Pitt's School of Medicine. The work was conducted through the Center for the Neural Basis of Cognition, which is jointly operated by Pitt and Carnegie Mellon University.

To produce the models, the Pitt team stamped adhesive proteins onto silicon discs. Once the proteins were cultured and dried, cultured hippocampus cells from embryonic rats were fused to the proteins and then given time to grow and connect to form a
'/>"/>

Contact: Morgan Kelly
mekelly@pitt.edu
412-624-4356
University of Pittsburgh
Source:Eurekalert  

Page: 1 2

Related biology news :

1. CCNY-led interdisciplinary team recreates colonial hydrology
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. During exercise, the human brain shifts into high gear on alternative energy
4. Millisecond brain signals predict response to fast-acting antidepressant
5. Food for thought -- regulating energy supply to the brain during fasting
6. Risk and reward compete in brain
7. Brainy genes, not brawn, key to success on mussel beach
8. Brain-nourishing molecule may predict schizophrenia relapse
9. Brain structure provides key to unraveling function of bizarre dinosaur crests
10. MU brain imaging center provides research for autism, schizophrenia and Parkinsons disease
11. Key to function of dinosaur crests found in brain structure
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pitt team recreates brain cell networks with new view of activity behind memory formation
(Date:4/23/2014)... in French and Spanish . ... 2014Today, the CEC released its Conservation Assessment for the ... Conservation, which identifies 29 priority conservation areas in a ... different protected areas in the states of Texas, Coahuila, ... and semi-arid habitats inhabited by rare and endangered plants ...
(Date:4/23/2014)... a unique rhythmic sound, recorded for decades in the ... minke whale ( Balaenoptera bonaerensis ). First described and ... it sounded like a duck, the bio-duck sound has ... but its source has remained a mystery, until now. ... deployed acoustic tags on two Antarctic minke whales in ...
(Date:4/23/2014)... TX (4/23/14) -- Researchers have found evidence of ... factors that increase aggressive behavior in children, especially ... not all children exposed to prenatal smoking will ... will not," said Brian Boutwell, Assistant Professor at ... and senior author on the study. "One ...
Breaking Biology News(10 mins):Conservation priorities released for several protected areas along US-Mexico border 2Conservation priorities released for several protected areas along US-Mexico border 3Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3Genetics risk, prenatal smoking may predict behavioral problems 2
... formed and how species remain separate are crucial questions in ... are often infertile or die when still in the womb. ... result of a cross between a sheep and a goat, ... example, because the sounds they make are a mixture of ...
... other planets and in extreme environments on Earth will ... under a five-year grant from NASA,s Astrobiology Institute for ... H. House, associate professor of geosciences, will lead an ... life, look for biological signatures in relevant ecosystems in ...
... release is available in Spanish . ... at the Institute for Research in Biomedicine (IRB Barcelona) ... Qumica" (ICIQ, Tarragona), have discovered a substance with the ... presents certain mutations that promote the appearance of cancer. ...
Cached Biology News:Turtle doves commit adultery 2Turtle doves commit adultery 3Penn State receives new NASA astrobiology grant 2Penn State receives new NASA astrobiology grant 3Design of a compound that stabilizes the main natural suppressor of tumors 2
(Date:1/15/2014)... Two champions of science, technology, engineering, and ... annual competition for middle and high school students designed ... study. The competition presents students with real-world problems experienced ... Mathematics, and Sciences is a program administered by ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched Sound ... Patients listen to sound therapy that is tailor-made for ... to months, their tinnitus volume decreases. , AudioNotch has previously ... Notched White Noise. Now, AudioNotch is pleased to announce to ...
(Date:1/14/2014)... 2014  3D Communications, a leading provider of strategic communications services to ... events in the United States and ... Cox , JD, is returning to the firm,s Washington, ... 3D after more than two years of service as Associate Commissioner ...
(Date:1/14/2014)... MA (PRWEB) January 14, 2014 iLab Solutions, ... Detwiler as the new Director of Product Strategy. In this ... well as iLab sub-teams to guide in the development of ... iLab provides the maximum possible benefit to the scientific community ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... Achieved an Objective Tumor Response by End of Four ... (Nasdaq: PPHM ) today reported that its ... in the first stage of its ongoing Phase II ... (NSCLC). The open-label, Simon two-stage study is designed ...
... Wis., Feb. 4 Mach One Corporation (Pink Sheets: ... develops biotechnology based solutions that produce positive, long term ... that it has signed a definitive agreement to acquire ... company that supplies ingredients to the food, feed and ...
... Kit provides a great introduction to the benefits of Shape Memory Alloys. ... labs, and provides both a comprehensive manual, and easy to follow demonstrations ... ... (PRWEB) February 4, 2009 -- Imagine a future where the only tool ...
Cached Biology Technology:Peregrine Pharmaceuticals' Bavituximab Achieves Primary Endpoint in First Stage of Phase II Lung Cancer Study 2Peregrine Pharmaceuticals' Bavituximab Achieves Primary Endpoint in First Stage of Phase II Lung Cancer Study 3Peregrine Pharmaceuticals' Bavituximab Achieves Primary Endpoint in First Stage of Phase II Lung Cancer Study 4Mach One Corporation Signs Definitive Agreement to Acquire Ceres Organic Harvest, Inc. 2Re-Shaping the Future with Shape Memory Alloys - SMA Starter Kit 2Re-Shaping the Future with Shape Memory Alloys - SMA Starter Kit 3
Conjugation services for Antibodies, Proteins, Oligos, Peptides, Beads, bioconjugation, antibody-oligonucleotide, LNA peptide, LNA protein, LNA antibody, HRP, Alkaline phosphatase, phycoerythrin, FIT...
SCP-1 (P-17)...
Immunogen: Purified native p24 from strain IIIB. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biotin d anti-mouse Tim-1...
Biology Products: