Navigation Links
Pitt team recreates brain cell networks with new view of activity behind memory formation
Date:5/25/2011

PITTSBURGHUniversity of Pittsburgh researchers have reproduced the brain's complex electrical impulses onto models made of living brain cells that provide an unprecedented view of the neuron activity behind memory formation.

The team fashioned ring-shaped networks of brain cells that were not only capable of transmitting an electrical impulse, but also remained in a state of persistent activity associated with memory formation, said lead researcher Henry Zeringue [zuh-rang], a bioengineering professor in Pitt's Swanson School of Engineering. Magnetic resonance images have suggested that working memories are formed when the cortex, or outer layer of the brain, launches into extended electrical activity after the initial stimulus, Zeringue explained. But the brain's complex structure and the diminutive scale of neural networks mean that observing this activity in real time can be nearly impossible, he added.

The Pitt team, however, was able to generate and prolong this excited state in groups of 40 to 60 brain cells harvested from the hippocampus of ratsthe part of the brain associated with memory formation. In addition, the researchers produced the networks on glass slides that allowed them to observe the cells' interplay. The work was conducted in Zeringue's lab by Pitt bioengineering doctoral student Ashwin Vishwanathan, who most recently reported the work in the Royal Society of Chemistry (UK) journal, Lab on a Chip. Vishwanathan coauthored the paper with Zeringue and Guo-Qiang Bi, a neurobiology professor in Pitt's School of Medicine. The work was conducted through the Center for the Neural Basis of Cognition, which is jointly operated by Pitt and Carnegie Mellon University.

To produce the models, the Pitt team stamped adhesive proteins onto silicon discs. Once the proteins were cultured and dried, cultured hippocampus cells from embryonic rats were fused to the proteins and then given time to grow and connect to form a
'/>"/>

Contact: Morgan Kelly
mekelly@pitt.edu
412-624-4356
University of Pittsburgh
Source:Eurekalert  

Page: 1 2

Related biology news :

1. CCNY-led interdisciplinary team recreates colonial hydrology
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. During exercise, the human brain shifts into high gear on alternative energy
4. Millisecond brain signals predict response to fast-acting antidepressant
5. Food for thought -- regulating energy supply to the brain during fasting
6. Risk and reward compete in brain
7. Brainy genes, not brawn, key to success on mussel beach
8. Brain-nourishing molecule may predict schizophrenia relapse
9. Brain structure provides key to unraveling function of bizarre dinosaur crests
10. MU brain imaging center provides research for autism, schizophrenia and Parkinsons disease
11. Key to function of dinosaur crests found in brain structure
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pitt team recreates brain cell networks with new view of activity behind memory formation
(Date:3/23/2015)... --  HOYOS Labs , a leading global authentication infrastructure ... Company will demonstrate multiple biometrics-based technologies under its identity ... on March 23 through 25, 2015, in ... IEEE Biometric Open Protocol Standard; free biometrics-based consumer app, ... system. BOPS was invented by HOYOS Labs and contributed ...
(Date:3/20/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) ... Global Strategic Business Report" report to their offering. ... in US$ Thousands. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific ... of World. Annual estimates and forecasts are provided ...
(Date:3/18/2015)... SPRINGS, Florida , March 18, 2015 ... well as businesses, new revolutionary smart wallets and apps continue ... pace.  Companies currently entrenched in the mobile payment industry in ... Alibaba Group Holding Ltd. (NYSE: BABA ), Apple ... GOOG ) and Facebook Inc. (NASDAQ: FB ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
... associate a picture with a reward, the reward by ... monkeys, visual cortex. This finding was made by neurophysiologists ... Medical School) and American colleagues using functional brain scans ... Neuron . Our visual perception is not determined ...
... and S. torgalensis , most generally belong to the ... largest fish, and vertebrate family, formed of freshwater fish with ... has an important economic value as a food source. More ... Leuciscinae , formed of small freshwater fish commonly known ...
... This press release is available in ... are indispensable for organisms. Function and evolution of these ... biology. Bioinformatician Thomas Rattei, University of Vienna, and physicist ... ancestral protein networks. The results are of high interest ...
Cached Biology News:Reward linked to image is enough to activate brain's visual cortex 2Genetic analysis calls for the protection of 2 highly endangered Portuguese fish species 2Novel insights into the evolution of protein networks 2Novel insights into the evolution of protein networks 3
(Date:4/17/2015)... Reed Technology and Information Services Inc. ... preparation, and submission to the U.S. Food and Drug ... Lot Distribution Report (LDR) service for manufacturers of biologics, ... the FDA’s new rule on electronic submission of LDRs. ... volume and timing of particular biologics introduced to the ...
(Date:4/17/2015)... Global Stem Cells Group has announced plans ... 27 - 29, 2015 in Boston. This world-class summit ... stem cell research including applications, biology, medicine, regulations, and ... , The conference will address recent developments in pre-clinical ... stem cell therapies, regenerative medicine, tissue engineering, stem cell ...
(Date:4/16/2015)... CAMBRIDGE, Mass. (PRWEB) April 16, 2015 ... of smart data solutions driven by Semantic Web ... provider of specialist information and services for the ... today announced that its joint solution ‘Smart Data ... named a finalist for the 2015 Bio-IT ‘Best ...
(Date:4/16/2015)... Morton Grove, IL (PRWEB) April 16, 2015 ... the American Association for Cancer Research (AACR) ... at the Pennsylvania Convention Center, starting Saturday, April 18, ... The AACR holds claim to title of the oldest ... several journals, provides fellowships and grants, and partners with ...
Breaking Biology Technology:Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 3Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Regis Technologies Joins American Association for Cancer Research Annual Meeting 2
... like Jack Welch and Larry Bossidy have been lionized ... attitude, relentless focus on bottom line performance and stellar ... run offer many valuable lessons, the management philosophies they ... for every company. Super Jacks rank and yank approach ...
... Engineering and Testing Services and Underwriters Laboratories have ... equipment building systems (NEBS) tests for telecommunications suppliers. ... such as seismic and transportation vibration, heat, humidity, ... not-for-profit product testing company, will provide customers of ...
... to be fooled by first impressions. And I have to admit ... Confoti in the January 2002 issue of DEMOletter, I was rather ... over the Internet. Dot-com businesses were imploding left and right ... site wouldn't be around for long. , ,I couldn't have been ...
Cached Biology Technology:Seven leadership lessons of Next Generation Companies 2Seven leadership lessons of Next Generation Companies 3Confoti: Revisiting a dotcom business model 2Confoti: Revisiting a dotcom business model 3Confoti: Revisiting a dotcom business model 4Confoti: Revisiting a dotcom business model 5
... Proteolytic degradation is critical to the ... and regulatory proteins as important and ... metabolism, heat shock and stress response, ... receptors and ion channels, cell cycle ...
... Proteolytic degradation is critical to ... short-lived and regulatory proteins as important ... cellular metabolism, heat shock and stress ... surface receptors and ion channels, cell ...
Each Yeast-GFP clone represents an individual S. cerevisiae strain containing an open reading frame with a C-terminal Aequorea Victoria GFP (S65T) fusion tag....
... be used for the identification of potential biomarkers ... and other diseases. Due to the fact that ... it provides an attractive alternative to blood plasma ... ProteoSpin Urine Protein Concentration Micro Kit provides ...
Biology Products: