Navigation Links
Pitt team identifies key protein causing excess liver production of glucose in diabetes
Date:9/28/2011

PITTSBURGH, Sept. 28 Researchers at the John G. Rangos Sr. Research Center at Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine have identified a powerful molecular pathway that regulates the liver's management of insulin and new glucose production, which could lead to new therapies for diabetes. The findings were published online this week in Diabetes, a journal of the American Diabetes Association.

Usually, the liver stores excess blood sugar as glycogen, which it doles out overnight during sleep and other periods of fasting to keep glucose levels within a normal physiological range, explained H. Henry Dong, Ph.D., associate professor of pediatrics, Pitt School of Medicine. But in diabetes, the liver continues to pump out glucose even when insulin is provided as a treatment.

"Scientists have been trying to find the factors that contribute to this liver overproduction of glucose for decades," Dr. Dong said. "If we can control that pathway, we should be able to help reduce the abnormally high blood sugar levels seen in patients with diabetes."

He and his team have been studying a family of proteins called Forkhead box or FOX, and for the current project focused on one called FOX06. They found that mice engineered to make too much FOX06 developed signs of metabolic syndrome, the precursor to diabetes, including high blood sugar and high insulin levels during fasting as well as impaired glucose tolerance, while mice that made too little FOX06 had abnormally low blood sugars during fasting.

"In a normal animal, a glucose injection causes blood sugar level to rise initially and then it goes back to normal range within two hours," Dr. Dong said. "In animals that made too much FOX06, blood sugar after a glucose injection doesn't normalize within two hours. They have lost the ability to regulate the level while the liver keeps making unneeded glucose."

Other experiment
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. International study identifies new gene targets for hypertension treatment
2. UT Southwestern program identifies families at high risk for colorectal cancer
3. Worldwide map identifies important coral reefs exposed to stress
4. Watermark ink device identifies unknown liquids instantly
5. Research identifies genes vital to preventing childhood leukemia
6. Scleroderma study identifies roadblocks to employment
7. Team identifies new breast cancer tumor suppressor and how it works
8. BUSM study identifies new potential approaches to treat myelofibrosis
9. Research identifies how cancer cells cheat death
10. TGen study identifies compounds that could slow down Alzheimers disease
11. AMIA identifies areas to strengthen Federal health IT strategic plan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... exists that cannabinoid receptor type 1 can ... influx, and reduce neurotransmitter release. However, some ... can increase extracellular Ca2+ influx and increase ... team, Tongji Hospital Affiliated to Tongji Medical ... China used whole cell voltage-clamp and calcium ...
(Date:7/11/2014)... Using spider toxins to study the proteins that let ... say they have stumbled upon a biological tactic that ... insect plagues in a safe and environmentally responsible way. ... be lethal for one species and harmless for a ... target specific pests without harming beneficial species like bees. ...
(Date:7/10/2014)... Fe, Albuquerque, and other major cities in New Mexico, ... treated municipal wastewater rather than precious potable water supplies. ... 40% of all golf courses receive treated effluent. Reusing ... , Additionally, golf courses and homeowners alike fertilize their ... fertilizer is nitrate. A New Mexico State University turfgrass ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3'Tailored' water -- the latest in lawn care 2
... 30 years with Chip Supply, Inc., President & CEO ... Perrott served in various capacities through the years, becoming ... Supply grew into the largest independent die distributor in ... of high reliability interconnect solutions, serving the military, aerospace, ...
... fulfill a range of diversified functions. Often such specialization ... places within a cell. It ensures that particular functions ... intracellular asymmetry in the otherwise fluid environment of the ... represent an especially important type of freight. They are ...
... through nearly 390,000 chemical compounds had led scientists to ... surrounding the brain with effects promising for new drugs ... substance, which blocks formation of cholesterol in the brain, ... Aleksey G. Kazantsev and colleagues previously discovered that blocking ...
Cached Biology News:How molecules get to the right place at the right time 2How molecules get to the right place at the right time 3
(Date:7/11/2014)... 11, 2014  Researchers have pioneered a revolutionary ... new technology, called Virtual Finger, allows scientists to ... neurons and synapses using the flat surface of ... 3D imaging studies orders of magnitude more efficient, ... level across many areas of experimental biology. The ...
(Date:7/10/2014)... Understanding the need for better quality and ... gap that currently exists in this area, ChanTest has ... of validated ion channel and GPCR cell lines. ... ion channels control many critical physiological functions throughout the ... potential to treat a variety of human diseases. ...
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has ... now comes with a second treatment cup to help prevent ... new cup is thinner on the edges for a softer ... thin and uneven surfaces on the face, neck and décolleté. ... treatment on areas such as the cheeks and neck, or ...
(Date:7/10/2014)... , July 10, 2014 /PRNewswire-iReach/ -- Tute ... interpretation, today announced an agreement with Lineagen, ... for Lineagen,s NextStep Dx PLUS.  Lineagen, ... and neurological disorders, currently offers FirstStep Dx ... testing service used by healthcare providers as ...
Breaking Biology Technology:Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... Mass., Sept. 19 PLC Systems Inc.,(Amex: PLC ... of failure to,meet listing qualifications dated September 17, 2008 ... Exchange. The notice,stated that the Company was not in ... the Company,s shareholders, equity was less,than $4,000,000 as of ...
... INNSBRUCK, Austria, September 19 Thirty seven medical,experts ... on the medical,community to take urgent action to ... mental illness such as schizophrenia or bipolar,disorder(i)., ... Illnesses in Patients with Severe Mental Disorders: Clinical,Policy, ...
... CLAREMONT, Calif., Sept. 18 Keck Graduate Institute,(KGI) ... program for industry,professionals to learn the latest developments ... "Mammalian cell biotechnology has undergone explosive growth over ... George B. and Joy Rathmann,Professor and director of ...
Cached Biology Technology:PLC Systems Receives Delisting Notice From American Stock Exchange 2Global Psychiatrists Unite to Improve Services in Mental Health 2Global Psychiatrists Unite to Improve Services in Mental Health 3KGI Offers Mammalian Cell Culture Program for Biotech Industry Professionals 2
... HandyStep electronic from BRAND adds ergonomics ... is the only electronic, motor-driven repeating ... tips, including BRAND PD-Tip syringe tips, ... Dispenser Tips,and VWRbrand Combi-Syringes. Select virtually ...
... The Nick Translation System is ideal ... DNA. The Nick Translation System: Provides ... labeled nucleotide incorporation Yields >10 8 ... Includes control DNA to monitor the performance ...
... printer is portable, easy-to-use and makes identifying your ... Easy to use Labels withstand ... slide sizes Time/Date stamp ... Serialization feature makes you more efficient ...
... cAMP - [125I] Direct SPA ... SPA.Includes lysis reagents that eliminate lengthy ... cAMP measurement (optional use).Range: 1.32-84.28 ng/ml ... pmol/ml).Overnight protocol.Store at 2-8 C. Category: ...
Biology Products: