Navigation Links
Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients
Date:7/6/2009

thor Kazuhisa Konishi, M.D., a visiting postdoctoral fellow in Dr. Kaminski's lab who performed the gene profiling. "But nearly 600 genes were differentially expressed between IPF patients who had accelerated disease and those who were stable."

There was no evidence that infection or inflammation was the cause of disease acceleration, he noted. Instead, there were indications that the cells of the alveolar epithelium, which is the tissue that covers the surface of the air sacs, were rapidly dying.

"That could mean that drugs that are used to protect the epithelium in other illnesses, such as cancer, might help IPF patients survive an exacerbation," said study co-author Kevin Gibson, M.D., associate professor in the Division of Pulmonary, Allergy and Critical Care Medicine at Pitt School of Medicine and medical director of the Simmons Center. "If we can keep them alive, there's a chance they could get a life-saving lung transplant."

To test whether the changes in the lungs could be revealed in the blood, the Pitt investigators contacted Dr. Kaminski's longtime collaborator, Dong Soon Kim, M.D., a renowned IPF researcher at Asan Medical Center and the University of Ulsan in Seoul, South Korea, who has been at the forefront of studying the acceleration syndrome. With her help, they found that levels of a protein called alpha-defensin were particularly high in the blood of patients experiencing an exacerbation. If the findings are verified with more research, which is underway, the proteins could be the first biomarker blood tests that doctors could track to identify patients at risk for sudden deterioration of lung function.

"This work opens an important window into the mystery of why patients with lung fibrosis suddenly decompensate and how to identify these patients for more aggressive therapies," said Mark T. Gladwin, M.D., chief of Pitt's Division of Pulmonary, Allergy and Critical Care Medicine. "Our current research efforts i
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. First direct evidence of substantial fish consumption by early modern humans in China
2. Ovarian transplantation: First baby is born after a new technique
3. First riser-drilling research operations undertaken
4. Childrens Hospital Oakland scientists first to discover new source for harvesting stem cells
5. Scientists capture the first image of memories being made
6. Universitat Autonoma de Barcelona researchers first to clone mice in Spain
7. First ever worldwide census analysis of caribou/reindeer numbers reveals dramatic decline
8. Wildlife Conservation Society supports worlds first study of egg-laying mammal
9. MSU researchers receive $400,000 in first wave of stimulus funding
10. Afghanistan releases its first-ever list of protected species
11. The first hyperspectral scanner in Spain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... NEW YORK , April 14, 2015 /PRNewswire/ ... Fast IDentity Online (FIDO ® ) Alliance tm ... standards-based specifications. FIDO members commit to share technology ... authentication methods that are interoperable, more secure and ... specifications enable biometric identity verification that protects sensitive ...
(Date:4/13/2015)... 13, 2015 According to ... Biometrics Market Forecast & Opportunities, 2020", the global biometrics ... around 14% till 2020. The biometrics market is ... implementation and review of biometric management systems. The ... products with greater efficiency, are resulting in increasing ...
(Date:4/10/2015)... 10, 2015 Research and Markets ... "Security Competitive Profiles - NEC" report to ... NEC will continue to supply a range of ... with a company focus on the development of a ... Winning opportunities in the Asia-Pacific ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2
... The University of Texas at Austin whose technology developments in ... tens of thousands of patients with diseases such as cancer ... Institute of Medicine (IOM). Established in 1970, IOM is ... institute is considered one of the highest honors in health ...
... ) in the Journal of Integrated Pest Management ... and education (PIPE), a program that provides a new ... in the southern tier of the United States. ... experts have developed and delivered this program via the ...
... Ga. Nearly all active people suffer ankle sprains at ... Georgia study suggests that the different ways people move their ... In the past, sports medicine therapists prescribed strengthening and ... The study by UGA kinesiology researchers, published in the early ...
Cached Biology News:UT professor elected to the Institute of Medicine of the National Academies 2UT professor elected to the Institute of Medicine of the National Academies 3UGA study suggests key to avoiding ankle re-injury may be in the hips and knees 2
(Date:5/28/2015)... , May 28, 2015  PDS Biotechnology ... cancer immunotherapy treatment targeting HPV-16, has generated strong ... Currently, pre-cervical cancer is treated by surgical ... simple and effective non-surgical alternative. Results show that ... (T-cells) to recognize, target, and kill precancerous and ...
(Date:5/28/2015)... , May 28, 2015  GenVec, Inc. (Nasdaq: ... CEO, Douglas J. Swirsky , will present a ... at 11 a.m. EDT on Thursday, June 4, 2015. ... Mr. Swirsky,s presentation will be available at the following ... available on GenVec,s website.  To access, visit www.genvec.com ...
(Date:5/28/2015)... Glenn Keet, CEO of Clinovo , will ... Data Integration with EDC Systems ” at the upcoming ... June 14th-18th. , During the presentation, Glenn Keet will ... and will examine the value of patient engagement, in ... records/electronic medical records integration. , The presentation will ...
(Date:5/28/2015)... 2015 American Process Inc. (Atlanta, ... TN) recently signed a joint agreement ... resins using nanocellulose, a rapidly emerging high performance, ... is the limited number of feedstock materials available. ... to printed parts for load bearing applications. ...
Breaking Biology Technology:PDS Biotechnology reports positive Phase I clinical trial results in proprietary HPV-Cancer Immunotherapy 2GenVec To Present At The Jefferies Healthcare Conference 2Clinovo Presents at the DIA 2015 51st Annual Meeting in Washington, DC on June 14th-18th 2American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 2American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 3
Whitewater, Wis . - Sharon Ethanol , a subsidiary of <a...
... media era, there are many companies trying to aggressively use ... site revamps to well thought-out, limited-term campaigns using new media. ... some recent examples demonstrating these concepts and their perceived impact. ... Dell back at the helm, Dell is aggressively ...
... Saint Luke's Health System of Kansas City, will be a keynote ... and 10 in Madison. He recently spoke to WTN from his ... of health information technology. , , WTN : What are ... , , John Wade Wade: I think ...
Cached Biology Technology:On the case: Web lessons for connecting with customers 2On the case: Web lessons for connecting with customers 3On the case: Web lessons for connecting with customers 4On the case: Web lessons for connecting with customers 5Visions: Wade offers straight talk on e-medical records 2Visions: Wade offers straight talk on e-medical records 3Visions: Wade offers straight talk on e-medical records 4Visions: Wade offers straight talk on e-medical records 5
... Blood Vessel Staining Kit is a very ... vascular endothelial cells, containing both anti-von Willebrand ... applicable to a variety of species. This ... for the staining of frozen and paraffin-embedded ...
... Applied Biosystems and MDS Sciex present ... a high performance hybrid triple quadrupole/linear ... drug discovery, drug development or proteomics ... Technology from the leaders in mass ...
... acid synthetic peptide whose sequence corresponds to residues 1-18 from rat ... carboxy terminus): M(1) - A - S - A - S ... P - R - D - A - A - D ... for neutralization and control experiments with the polyclonal antibody that reacts ...
... is a fixative useful for routine procedures. ... is stable and will decalcify small bone ... can be stained successfully with most stains, ... stabilizes red blood cell membranes and cosinophil ...
Biology Products: