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Pitt team finds protein that sets the stage for exchanges of DNA code in eggs and sperm
Date:10/13/2010

nd-1): crossovers instead occurred in the gene-rich, central areas of the chromosomes; and crossovers on the X chromosome often did not occur.

"This is the first gene in any system that is specifically required for the segregation of single chromosomes," she said. "The fact that this is the X chromosome is interesting because the sex chromosomes play a unique role both in germ line and general development."

These observations led the researchers to suggest that xnd-1affects the way chromosomes are packaged into the nucleus of the cell as a DNA protein complex known as chromatin. They further showed xnd-1 alters a component of chromatin that has been maintained through species evolution and that this packaging is directly responsible for the effects on crossover formation.


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Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

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