Navigation Links
Pitt team finds melatonin delays ALS symptom onset and death in mice
Date:4/24/2013

Melatonin injections delayed symptom onset and reduced mortality in a mouse model of the neurodegenerative condition amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, according to a new study by researchers at the University of Pittsburgh School of Medicine. In a report published online ahead of print in the journal Neurobiology of Disease, the team revealed that receptors for melatonin are found in the nerve cells, a finding that could launch novel therapeutic approaches.

Annually about 5,000 people are diagnosed with ALS, which is characterized by progressive muscle weakness and eventual death due to the failure of respiratory muscles, said senior investigator Robert Friedlander, M.D., UPMC Endowed Professor of neurosurgery and neurobiology and chair, Department of Neurological Surgery, Pitt School of Medicine. But the causes of the condition are not well understood, thwarting development of a cure or even effective treatments.

Melatonin is a naturally occurring hormone that is best known for its role in sleep regulation. After screening more than a thousand FDA-approved drugs several years ago, the research team determined that melatonin is a powerful antioxidant that blocks the release of enzymes that activate apoptosis, or programmed cell death.

"Our experiments show for the first time that a lack of melatonin and melatonin receptor 1, or MT1, is associated with the progression of ALS," Dr. Friedlander said. "We saw similar results in a Huntington's disease model in an earlier project, suggesting similar biochemical pathways are disrupted in these challenging neurologic diseases."

Hoping to stop neuron death in ALS just as they did in Huntington's, the research team treated mice bred to have an ALS-like disease with injections of melatonin or with a placebo. Compared to untreated animals, the melatonin group developed symptoms later, survived longer, and had less degeneration of motor neurons in the
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rescue me: New study finds animals do recover from neglect
2. Gene sequencing project finds new mutations to blame for a majority of brain tumor subtype
3. Exercise or make dinner? Study finds adults trade one healthy act for another
4. Sustainable fishing certification too lenient and discretionary, study finds
5. Couch potatoes may be genetically predisposed to being lazy, MU study finds
6. Notre Dame study finds Asian carp DNA not widespread in the Great Lakes
7. Marriage can threaten health: Study finds satisfied newlyweds more likely to gain weight
8. Southern California sagebrush better suited to climate change, UCI study finds
9. Pitt team finds immunity protein that ramps up inflammation, and agents that can block it
10. Study finds strong genetic component to childhood obesity
11. Do I know you? Memory patterns help us recall the social webs we weave, finds new Cornell study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ( ... Market Monitor: North America Perimeter Security Systems Market" report ... The North American perimeter security market is estimated ... 2019. Although the U.S. market holds a larger share in ...
(Date:12/17/2014)... NEW YORK , Dec. 15, 2014  HITLAB SM ... Practices (GCP) audit to confirm its adherence to current ... enables HITLAB to conduct regulated smart device and smart ... safety and research quality. "HITLAB is determined ...
(Date:12/11/2014)... Research and Markets , ... announced the addition of the "Biometrics Market in ... One major trend emerging in this market ... it is important to upgrade biometric solutions to the ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... entomologists are set to meet next week at the ... as the North Central Branch of the Entomological Society ... topics will include public health/bed bug entomology, biocontrol of ... and Sontrol tactics, soybean aphid management, and insect biodiversity ...
... -- It,s a cloak that surpasses all others: a ... the way bacteria and other cells are imaged. ... State University, and his research team are wrapping bacteria ... under electron microscopes. Berry,s method creates a carbon cloak ...
... , This release is available in Spanish ... grass breeder has rediscovered a forage grass that seems just ... of an unusual forage grass led Michael Casler, an Agricultural ... Research Center in Madison, Wis., to identify the grass as ...
Cached Biology News:All wrapped up: K-State researcher's graphene cloak protects bacteria, leading to better images 2All wrapped up: K-State researcher's graphene cloak protects bacteria, leading to better images 3Dairy farmer finds unusual forage grass 2
(Date:1/22/2015)... CO / Rootstown, OH (PRWEB) January 22, 2015 ... detection platform, announced today that it has received AOAC-PTM Certifications ... O45, O1O3, O111, O121, and O145; collectively referred to as ... coli) O157, at 1 colony forming unit (cfu) per 325 ...
(Date:1/22/2015)... 22, 2015 Selexis SA, a serial ... Cell Banks (RCBs) used for drug discovery to commercial ... will include Next-Generation Sequencing (NGS) data packages. ... biologic manufacturing by ensuring the integrity of the gene, ...
(Date:1/22/2015)...   GenoSpace , a precision medicine software company that has ... use of genomic, imaging and other biomedical data in research ... Munson , CEO of Aspera, an IBM Company, to its ... http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased to welcome ...
(Date:12/24/2014)... 24, 2014  Vermillion, Inc. (Nasdaq:   VRML), a ... today that the Company closed its previously announced ... Jack W. Schuler , Birchview Fund LLC ... million, before offering expenses.  The proceeds will be ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... no yellow tape or chalk outlines of a body, but ... want remedies, said a lawyer who spoke at the ... a partner with Michael Best & Friedrich , said ... or disgruntled employees can benefit from learning to work with ...
... a warning for chief information officers: By 2007, 80 percent ... executives. The CEO of Paragon Development Systems , an ... to stay involved with the business side of their companies ... change in a really short period of time," he said. ...
... If, five years ago, you asked a group of ... have said storage capacity, security or bandwidth. , ,Today, ... spate of securities legislation, highlighted by Congress's passage of ... has come to be called. SOX, which was passed ...
Cached Biology Technology:After a successful attack on your computer systems, then what? 2After a successful attack on your computer systems, then what? 3IT outsourcing remains on the horizon as companies focus on core business 2IT outsourcing remains on the horizon as companies focus on core business 3With Sarbanes-Oxley, compliance takes center stage for CIOs 2With Sarbanes-Oxley, compliance takes center stage for CIOs 3
... of BAC (100+kb), fosmid (40kb), and large ... than any othe BAC vector. On command ... and easy recombinant DNA purification. Available with ... VC) vectors for the highest insert stability. ...
... cloning of BAC (100+kb), fosmid (40kb), and ... stability than any othe BAC vector. On ... yields and easy recombinant DNA purification. Available ... (pSMART VC) vectors for the highest insert ...
RABBIT ANTI GLYCINE...
Request Info...
Biology Products: