Navigation Links
Pitt study: Lung lesions of TB variable, independent whether infection is active or latent
Date:12/15/2013

PITTSBURGH, Dec. 15, 2013 The lung lesions in an individual infected with tuberculosis (TB) are surprisingly variable and independent of each other, despite whether the patient has clinically active or latent disease, according to a new animal study led by researchers at the University of Pittsburgh School of Medicine. The findings, published online today in Nature Medicine, could point the way to new vaccines to prevent the hard-to-treat infection.

More than 30 percent of the world's population is infected with Mycobacterium tuberculosis, the bacterium that causes TB, yet only 5 to 10 percent of those infected develop active, contagious disease with symptoms of coughing, chest pain, night sweats and weight loss. Most have asymptomatic, or "latent," infections that are not contagious, but could become active years later.

When the lungs become infected with M. tuberculosis, the body's immune system walls off the bacteria into lesions called granulomas, explained co-senior investigator JoAnne Flynn, Ph.D., professor of microbiology and molecular genetics, Pitt School of Medicine.

"It's long been thought that the patient with a weakened immune system or some other immune vulnerability was more likely to develop active disease," Dr. Flynn said. "But to our surprise, our study showed that every infected individual has a collection of granulomas, some containing live bacteria and some that are sterile because the immune system has killed all the bacteria. So in this sense, there's no such thing as a latent or active granuloma."

For the study, the research team infected monkeys with TB and then carefully tracked the granulomas that developed in the lungs. They determined that each granuloma starts with only one bacterium, and that bacterial replication continued for about four weeks before the body counters with an adaptive immune response to kill off the invaders.

"This response was sufficient to kill all the
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Dallas study: Initial success for new tinnitus treatment
2. Drexel study: Consumers order a less unhealthy meal when the menu has nutritional labeling
3. Study: Metformin for breast cancer less effective at higher glucose concentrations
4. Study: Death by moonlight? Not always
5. Study: Acidity can change cell membrane properties
6. Penn study: Shutting off neurons helps bullied mice overcome symptoms of depression
7. Rutgers study: Worms may shed light on human ability to handle chronic stress
8. UT study: Chemical in antibacterial soaps may harm nursing babies
9. Study: Pedometer program helps motivate participants to sit less, move more
10. Study: MicroRNA cooperation mutes breast cancer oncogenes
11. Study: Environmental policies matter for growing megacities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Branch at Galveston are the first to recommend ... cancer should begin colorectal cancer screening earlier than ... a high incidence of secondary colorectal cancers among ... recommendations that the younger women in this group ... their initial cervical cancer diagnosis instead of waiting ...
(Date:4/17/2014)... "The Modern View of Domestication," a special feature of ... of Sciences ( PNAS ) published April 29, ... in our deep history that most of us take ... Age, people in many spots around the globe shifted ... cultivating livestock and plants. , It seems so straightforward ...
(Date:4/16/2014)... researchers have identified a new syndrome called "osteosarcopenic obesity" ... mass with obesity. , "It used to be the ... bones would be because the bones were supporting more ... Nutrition at Florida State. "But, that,s only true to ...
Breaking Biology News(10 mins):Radiation therapy for cervical cancer increases risk for colorectal cancer 2Genetic study tackles mystery of slow plant domestications 2Genetic study tackles mystery of slow plant domestications 3Genetic study tackles mystery of slow plant domestications 4Researchers: Obesity can amplify bone and muscle loss 2
... January 2014.- The gene therapy-based research project to tackle ... Institute for Research in Biomedicine (IRB), in Barcelona, and ... Madrid, has received 100,000 US$ per year for two ... is one of the main patients, organisations in the ...
... a deadly pathogen,s family tree may have ended centuries ago, ... with links to the modern world. An international team ... devastating pandemicsthe plague of Justinian and the Black Death, each ... Europewere caused by distinct strains of the same pathogen. ...
... a century, the Hell Creek and Fort Union formations ... paleontologists alike. In Montana and adjacent areas, these rocks ... rex and the epicenter for debate surrounding the mass ... The 15 chapters in this volume represent a surge ...
Cached Biology News:International patient alliance to fund Spanish Friedreich's ataxia gene-therapy project 2Research uncovers historical rise, fall and re-emergence of plague strains 2Research uncovers historical rise, fall and re-emergence of plague strains 3
(Date:1/14/2014)... Texas , Jan. 14, 2014 The ... and research medicinal plants and therapeutic derivatives thereof ... health professionals, and researchers about the challenges of ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society ...
(Date:1/14/2014)... In recent years, growing suspicion about the ... development and promotion has led to unprecedented levels of ... concerns about the insidious impact of commercialization of research, ... to the world’s biggest pharmas for illegal marketing activities, ...
(Date:1/14/2014)... 14, 2014   Kinaxis ®, provider of RapidResponse ®, ... and operations planning ( S&OP ) service, is proud to ... which will be held at the Hilton San Diego Bayfront, ... customer Elisabeth Kaszas , Director of Supply Chain at ...
(Date:1/14/2014)... During the 1600’s through the 1800’s doctors contributed ... In this time period, doctors did not know that they ... the death of vulnerable patients. In the same way, medical ... be unwittingly transmitting herpes viruses to their patients. The CBCD ...
Breaking Biology Technology:World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... Wis. - Imago Scientific Instruments Corp. , a ... materials, has won acclaim for the updated capabilities of its ... by Research and Development Magazine recently recognized the ... Tim Stultz, president and CEO of Imago, said the microscope, ...
... for Wisconsin governor are playing a game of one- upsmanship on ... turn to up the ante after Gov. Jim Doyle ... for ethanol. , ,Green, however, did not take that opportunity to ... he once voted for legislation to repeal the controversial law. Instead, ...
... - According to a recent article in Wisconsin Technology ... not only improve Wisconsin's business climate, but also put us ... of mutual cooperation and regional planning is what saved Denver ... ,Wait a minute. Wasn't Denver and all of Colorado reduced ...
Cached Biology Technology:Green doesnt up the ante on markup law 2Denver prospered because of "dreaded" TABOR 2Denver prospered because of "dreaded" TABOR 3
Best pricing for 100mg-1.0g scales. Phosphopeptides are our specialty....
... The JNK (c-Jun NH2-terminal kinase) signal ... identified MAP kinase pathways in mammals. ... to environmental stress, is associated with ... and is implicated in the immune ...
... 2D is an automated, two-dimensional fractionation system ... Part of Beckman Coulters ProteomeLab family ... in just hours. The system effectively ... cell lysates, addressing a key challenge in ...
... PA 800 is an automated, high-resolution ... Beckman Coulters ProteomeLab family of products, ... range of automated protein characterization solutions ... isoelectric focusing, carbohydrate profiling and mechanisms ...
Biology Products: