Navigation Links
Pitt researchers find promising candidate protein for cancer prevention vaccines
Date:8/4/2009

PITTSBURGH, Aug. 4 Researchers at the University of Pittsburgh School of Medicine have learned that some healthy people naturally developed an immune response against a protein that is made in excess levels in many cancers, including breast, lung, and head and neck cancers. The finding suggests that a vaccine against the protein might prevent malignancies in high-risk individuals.

Mice that were vaccinated to boost their immune response against this cell cycle protein, called cyclin B1, were able to reject a tumor challenge in which they were exposed to a cancer cell line that overproduced it, explained senior author Olivera Finn, Ph.D., Distinguished Professor and chair of the Department of Immunology at the Pitt School of Medicine. The results are reported this week in the online version of the Proceedings of the National Academy of Sciences.

"Cyclin B1 is known to be produced in excess amounts in several kinds of cancer," she said. "While we were studying it, we noted that many healthy people already had an immune response, or antibodies, against the protein, even though they'd never had cancer."

According to the researchers, the immune response most likely developed during a childhood viral infection, when inflammatory responses are strong. Cells infected with chicken pox virus, for example, look very much like tumor cells because they, too, overproduce cyclin B1. The virus actually packages the host protein, which ultimately gets shown to the immune system as a marker of infected cells that must be destroyed.

"Because cyclin B1 is a 'self' protein, there have been concerns that boosting the immune response against it would produce autoimmunity and create new problems," Dr. Finn said. "But now that we know that perhaps 20 to 30 percent of people already recognize it as abnormal when made in excess, we can be more confident about the safety of a vaccine strategy to immunize high-risk groups against it."

'/>"/>
Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. K-State researchers say after-school programs should promote activity, healthy nutrition
2. MU researchers create drought conditions to unearth solutions
3. Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers
4. UCSF researchers identify new drug target for Kaposis sarcoma
5. Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
6. 1 in 6 health workers wont report in flu pandemic -- study by Ben-Gurion U. researchers
7. Researchers team up to provide new hope for childhood hunger
8. UBC researchers help push for standard DNA barcodes for plants
9. Researchers develop brain-reading methods
10. ISU researchers find possible treatment for spinal muscular atrophy
11. Researchers capture bacterial infection on film
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market, announces it ... Conference on January 29 th at 10:30 a.m. ... of NXT-ID will present and host a live Q&A ... and its full suite of biometric technologies. Investors can ...
(Date:1/22/2015)... Valid S.A. ("Company") (BM&FBOVESPA: VLID3 ON), is pleased to inform ... State of Washington,s Department of Licensing, in the ... issuance system for driver,s licenses and identification cards to its ... development will start in January 2015, with enrollment and card ...
(Date:1/22/2015)... Jan. 16, 2015  A man-made form of insulin delivered ... mental capabilities in adults with mild cognitive impairment and ... by researchers at Wake Forest Baptist Medical Center. ... amnesic mild cognitive impairment (MCI) or mild to moderate ...
Breaking Biology News(10 mins):CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3Valid USA Signs Contract For Washington Driver's License Issuance 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3
... the last decade, Asian farmers have cleared tens of thousands ... demand for palm oil, an increasingly popular food ingredient. Ancient ... cut down. As a result, the landscape of equatorial Asia ... and having a serious impact on the air as well ...
... UC Santa Barbara have made a significant discovery in understanding ... nature,s way of controlling whether these cells will renew, or ... or any other part of the human body. The study ... Cell . The scientists say the finding bodes ...
... flu interventions must be imposed quickly, if they are ... journal BMC Public Health have shown that ... within the home should reduce infection, but only if ... maintained for a relatively long period. Professor George ...
Cached Biology News:NASA study says climate adds fuel to Asian wildfire emissions 2NASA study says climate adds fuel to Asian wildfire emissions 3NASA study says climate adds fuel to Asian wildfire emissions 4Scientists shed light on inner workings of human embryonic stem cells 2Scientists shed light on inner workings of human embryonic stem cells 3Social separation stops flu spread, but must be started soon 2
(Date:2/27/2015)... , Feb. 27, 2015 A ... the NCATS rare-diseases portfolio " in Science ... new financing technique to reduce the risk associated ... and potentially unlock new levels of funding for ... product of a unique collaboration between scientists at ...
(Date:2/27/2015)... -- Bionomics Limited (ASX:BNO, ADR:BMICY) is to present important ... patients with metastatic renal cancer at the ASCO Genitourinary ... The data will be presented by Dr. Sumanta ... Center in California in his ... Ferritin and IL-8 as two baseline biomarkers that correlate ...
(Date:2/27/2015)...  Steep Hill, the industry leader in cannabis testing ... open a full service medical cannabis quality assurance laboratory ... advanced scientific tools and methodology to the state, for ... currently the only laboratory licensed by the New Mexico ... in order to meet the recently adopted regulatory requirements ...
(Date:2/26/2015)... , Feb. 26, 2015  23andMe, the leading ... Kate Black as Privacy Officer and Corporate Counsel. ... state privacy laws as well as health care regulations. ... she will be responsible for reviewing, updating and enhancing ... the U.S. and abroad. She joined the company January ...
Breaking Biology Technology:New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 3New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 2New BNC105 Biomarker Data to be Presented at US Cancer Conference 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 5Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 223andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2
... Although the <A , href="http://www.ambion.com/catalog/CatNum.php?1632"> ... were developed for labeling siRNA, they can , ... can be used for this application. See "<A , ... Introduced dsRNA in Cells " for experimintal data using dsRNA , ...
... , May 20, 2002, ... initially considered a bizarre phenomenon limited to petunias and a few ... topics in molecular biology , (<A , ... it has become clear that PTGS occurs in both plants , ...
... border=0 align="left" cellPadding=8 cellSpacing=1>, , ... Assays , Northern Blotting , ... , , ... Yes , Yes , Yes ...
Cached Biology Technology:Fluorescently Labeling Long dsRNA with the Silencer siRNA Labeling Kit 2Fluorescently Labeling Long dsRNA with the Silencer siRNA Labeling Kit 3Fluorescently Labeling Long dsRNA with the Silencer siRNA Labeling Kit 4RNA Interference and Gene Silencing: History and Overview 2RNA Interference and Gene Silencing: History and Overview 3RNA Interference and Gene Silencing: History and Overview 4RNA Interference and Gene Silencing: History and Overview 5RNA Interference and Gene Silencing: History and Overview 6RNA Interference and Gene Silencing: History and Overview 7RNA Interference and Gene Silencing: History and Overview 8RNA Interference and Gene Silencing: History and Overview 9RNA Interference and Gene Silencing: History and Overview 10RNA Interference and Gene Silencing: History and Overview 11RNA Interference and Gene Silencing: History and Overview 12RNA Interference and Gene Silencing: History and Overview 13RNA Interference and Gene Silencing: History and Overview 14RNA Interference and Gene Silencing: History and Overview 15RNA Interference and Gene Silencing: History and Overview 16RNA Interference and Gene Silencing: History and Overview 17RNA Interference and Gene Silencing: History and Overview 18RNA Interference and Gene Silencing: History and Overview 19RNA Interference and Gene Silencing: History and Overview 20RNA Interference and Gene Silencing: History and Overview 21RNA Interference and Gene Silencing: History and Overview 22RNA Interference and Gene Silencing: History and Overview 23RNA Interference and Gene Silencing: History and Overview 24Comparison of Different Methods of mRNA Quantitation 2Comparison of Different Methods of mRNA Quantitation 3
sterile filtered, off the clot, all male donors, Total Protein: 4.5 to 8.5 g/dl...
Normal human AB serum, pooled...
Recombinant Human HGF...
Recombinant Mouse MMP-9, CF...
Biology Products: