Navigation Links
Pitt researchers describe molecular '2-step' leading to protein clumps of Huntington's disease
Date:3/8/2009

PITTSBURGH, March 8 In a paper published in the early online version of Nature Structural and Molecular Biology, researchers at the University of Pittsburgh School of Medicine deconstruct the first steps in an intricate molecular dance that might lead to the formation of pathogenic protein clumps in Huntington's disease, and possibly other movement-related neurological disorders.

Huntington's is one of 10 diseases in which a certain protein, different for each disease, contains polyglutamine, a stretch of repeating blocks of the amino acid glutamine, explained Ronald Wetzel, Ph.D., professor in the Department of Structural Biology and member of the Pittsburgh Institute for Neurodegenerative Diseases at the University of Pittsburgh School of Medicine. The affected protein in Huntington's disease is called huntingtin.

Most people have a huntingtin protein whose polyglutamine segment contains 20 or so glutamines, and even a polyglutamine with as many as 35 repeats may not cause Huntington's symptoms. But the risk of developing Huntington's disease rises sharply in individuals whose polyglutamine sequences are only slightly larger. A block of 40 repeats, for example, is associated with a very high likelihood of having the disease.

"To a protein chemist, this is a fascinating situation," Dr. Wetzel said. "Polyglutamine doesn't seem to play a sophisticated role in these proteins, and it doesn't have a defined structure. Yet by changing its length to only a very slight extent, it takes on some new physical properties that somehow initiate diseases."

One consequence of the lengthening is protein aggregation, or clumping, a feature that consistently appears in brain cells of patients who have one of these neurodegenerative diseases. Many research groups, including Dr. Wetzel's, study how polyglutamine expansion alters the huntingtin protein's behavior.

In its most recent studies, the Pitt team worked out the details o
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Climate change affecting Europes birds now, say researchers
2. CSHL researchers pinpoint structure-building role for 2 non-coding RNAs
3. Ben-Gurion University of the Negev researchers develop new reversible, green window technology
4. Two UT Southwestern researchers awarded Sloan fellowships
5. 2 McGill researchers garner prestigious NSERC Steacie Fellowships
6. Texas Obesity Research Center at UH assembles researchers to discuss obesity
7. U-M researchers ID gene involved in pancreatic cancer
8. USC researchers identify gene variant associated with both autism and gastrointestinal dysfunction
9. Researchers piggyback to safer reprogrammed stem cells
10. Researchers capture wave of brain activity linked to anticipation
11. UMMS researchers publish DNA identification of czars children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... 2015 High crime rate, ... boosting access control systems market in Saudi ... recently published report by TechSci Research " Saudi Arabia Access ... control systems market in Saudi Arabia ... access control systems market in the Kingdom is growing ...
(Date:4/17/2015)... , April 17, 2015 ... security concerns, and technological advancement to drive biometric ... until 2020   According to ... Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems market ... projected to register growth at CAGR of over ...
(Date:4/13/2015)... 13, 2015 According to ... Biometrics Market Forecast & Opportunities, 2020", the global biometrics ... around 14% till 2020. The biometrics market is ... implementation and review of biometric management systems. The ... products with greater efficiency, are resulting in increasing ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... The National Science Foundation (NSF) is funding a new ... high-achieving science and math undergraduates for teaching careers. ... within the College of Arts and Sciences at Case ... majors to become high school math and science teachers. ...
... Assistant Professor of Biomedical Engineering and Orthopedic Surgery has ... in Aging by The Ellison Medical Foundation. Case Western ... to submit a proposal, and Alsberg was one of ... National competition was strong, with only 25 awards being ...
... virulent avian influenza virus strain called H5N1 forms tiny tubules ... during viral infection, which otherwise would prompt an antiviral immune ... in an online report in the journal Nature . ... to form tiny tubules where double-stranded RNA is hidden from ...
Cached Biology News:NSF grant to launch undergrads from Case Western Reserve into math and science teaching 2NSF grant to launch undergrads from Case Western Reserve into math and science teaching 3Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award 2Protein 'tubules' free avian flu virus from immune recognition 2
(Date:5/21/2015)... (PRWEB) May 21, 2015 As part ... Medical Center (BDWMC), Sun Health Foundation funded a $3.25 ... new inpatient pharmacy with the most up-to-date features and ... June 2. The pharmacy's 45 staff members will begin ... 4,895-square-foot space in the coming days. , The ...
(Date:5/21/2015)... 21, 2015 Veolia’s environmental monitoring ... North American distribution agreement with VWR to distribute ... With more than 160 years of experience, VWR, ... for laboratory and production facilities, has cultivated a ... differentiated services to enable science. Endetec’s TECTA™ ...
(Date:5/20/2015)... May 20, 2015 Research and Markets ... "Top Technologies in HW_Technical Insights" report to ... report evaluated technology trends in the Health and Wellness ... likely to have an impact in the year 2015. ... the top 10 health and wellness technologies that are ...
(Date:5/20/2015)... Pa. , May 20, 2015  Select ... that the Federal Trade Commission granted early termination ... Antitrust Improvements Act of 1976, as amended, applicable ... MJ Acquisition Corporation, a joint venture that Select ... L.P. As previously announced, MJ Acquisition ...
Breaking Biology Technology:Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 3Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Top Technologies in the Health and Wellness Industry 2015 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2
... the lithium batteries used in portable devices, including ... to be published in the Inderscience publication - ... nanotubes can prevent such batteries from losing their ... Shenyang National Laboratory for Materials Science, in China, ...
... VRML ), a molecular diagnostics company, today ... board of directors. Mr. Hamilton is,the former vice ... a,specialty pharmaceutical company., "John brings more than ... and audit matters to Vermillion. His solid experience,working ...
... Reach Wide Investor Audience, SPO Medical Inc. (SPOM), ... in portable monitoring devices,announced today that it will be ... platform on April 29, 2008 at 1 PM,Eastern Daylight ... Medical is a company,on the move, though many investors ...
Cached Biology Technology:Sweet nanotech batteries 2Vermillion Announces Appointment of John Hamilton to Board of Directors 2SPO Medical to Conduct Live Investor Meeting on April 29, 2008 2SPO Medical to Conduct Live Investor Meeting on April 29, 2008 3
Human Serpin A8/AGT Affinity Purified Polyclonal Ab Keywords: Ang II, AngII, Hypertension, Salt Homeostasis, Pre-eclampsia...
Human/Mouse G9a/EHMT2 MAb (Clone A8620A) Keywords: Eu-HMTase2...
Mouse GDF-8 Propeptide Affinity Purified Polyclonal Ab...
SRY (sex determining region Y)-box 10...
Biology Products: