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Pitt research suggests EPA pesticide exposure test too short, overlooks long term effects
Date:8/17/2009

PITTSBURGHThe four-day testing period the U.S. Environmental Protection Agency (EPA) commonly uses to determine safe levels of pesticide exposure for humans and animals could fail to account for the toxins' long-term effects, University of Pittsburgh researchers report in the September edition of Environmental Toxicology and Chemistry.

The team found that the highly toxic pesticide endosulfana neurotoxin banned in several nations but still used extensively in U.S. agriculturecan exhibit a "lag effect" with the fallout from exposure not surfacing until after direct contact has ended. Lead author Devin Jones, a recent Pitt biological sciences graduate, conducted the experiment under Rick Relyea, an associate professor of biological sciences in Pitt's School of Arts and Sciences, with collaboration from Pitt post-doctoral researcher John Hammond. The paper is available on Pitt's Web site at www.pitt.edu/news2009/Endosulfan.pdf

The team exposed nine species of frog and toad tadpoles to endosulfan levels "expected and found in nature" for the EPA's required four-day period, then moved the tadpoles to clean water for an additional four days, Jones reported. Although endosulfan was ultimately toxic to all species, three species of tadpole showed no significant sensitivity to the chemical until after they were transferred to fresh water. Within four days of being moved, up to 97 percent of leopard frog tadpoles perished along with up to 50 percent of spring peeper and American toad tadpoles.

Of most concern, explained Relyea, is that tadpoles and other amphibians are famously sensitive to pollutants and considered an environmental indicator species. The EPA does not require testing on amphibians to determine pesticide safety, but Relyea previously found that endosulfan is 1,000-times more lethal to amphibians than other pesticides. Yet, he said, if the powerful insecticide canno
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Contact: Morgan Kelly
mekelly@pitt.edu
412-624-4356
University of Pittsburgh
Source:Eurekalert

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