Navigation Links
Pitt-led researchers create quick, simple fluorescent detector for TB
Date:3/19/2009

PITTSBURGHResearchers from the University of Pittsburgh and the Albert Einstein College of Medicine have developed an onsite method to quickly diagnose tuberculosis (TB) and expose the deadly drug-resistant strains of Mycobacterium tuberculosis that can mingle undetected with treatable strains. The researchers engineered bacteriophagestiny viruses that attack bacteriato inject TB bacteria with a glowing, fluorescent-green protein. They report their findings in the March 19 edition of PLoS ONE, a peer-reviewed online journal from the Public Library of Science.

The method must next undergo clinical trials, but it has potential as a valuable, timesaving tool in rural African areas besieged by TB, explained the paper's senior author Graham Hatfull, chair and Eberly Family Professor of Biological Sciences in Pitt's School of Arts and Sciences. Hatfull conducted the research with Professor William Jacobs Jr. of the Department of Microbiology and Immunology at the Albert Einstein College of Medicine of Yeshiva University in New York and Pitt postdoctoral fellow Mariana Piuri.

"A report from South Africa showed that the extensively drug-resistant TB strains can kill within 16 days, on average," Hatfull said. "In rural Africa, it takes too long to collect samples, send them off, do the test, and have the data sent back. Clinicians need rapid, relatively cheap, and simple methods for detecting TB and drug-resistant strains at the local clinic. This test provides a quick diagnosis so the patient can be isolated and treated."

The group constructed bacteriophages specific to TB that have a green fluorescence protein (GFP) implanted in their genome. Bacteriophages spread by injecting their DNA into bacterial cellsin this case the GFP gene accompanies the DNA into the TB cell, causing the cell to glow. A clinician can detect the GFP's glow with equipment available at many clinics.

Besides quick diagnosis, the test also could be used
'/>"/>

Contact: Morgan Kelly
mekelly@pitt.edu
412-624-4356
University of Pittsburgh
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... DUBLIN , Mar. 24, 2015 Research and ... addition of the "Global Iris Recognition Market 2015-2019" ... forecast the Global Iris Recognition market to grow at ... This report covers the present scenario and ... for the period 2015-2019. To calculate the market size, ...
(Date:3/23/2015)... , March 23, 2015 SoundView Technology Group ... NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView was one ... feedback on their experience with the Wocket in multiple scenarios ... CVS, Whole Foods and other retailers, making both debit and ... Tuttle also says, "If the company meets their plans ...
(Date:3/20/2015)... 2015 Research and Markets ( ... "India Sensors Market Forecast and Opportunities 2020" ... sensor market is projected to grow at a ... electronics, automotive, industrial and healthcare sectors are the ... In addition, adoption of MEMS technology in sensors ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... ON - In a new study from Lawson Health ... genetic pathway influencing the spread of cancer cells. The ... for treatment. Regular cell division is regulated by ... to ensure cells divide at a healthy, balanced rate. ...
... 3, 2012) A new book produced by the ... how well-managed protected areas with good law enforcement have ... of insecurity and war. , The book documents how ... on the planet, faces a variety of challenges from ...
... and improve lung-cancer screening by combining a blood test with ... trial combines a CT chest scan and the EarlyCDT-Lung blood ... recent research demonstrating that CT screening alone can reduce lung-cancer ... high-risk patients can reduce lung-cancer deaths. But we need to ...
Cached Biology News:Africa's Rift Valley saved by parks 2Trial seeks improved lung-cancer screening by combining imaging and biomarkers 2
(Date:3/26/2015)... San Bruno, CA (PRWEB) March 26, 2015 ... organization (CRO), announced today several management and executive ... role of Chief Financial Officer (CFO) and member of ... Vice President of Business Operations, and Sue Dowden will ... Tony Taricco, co-founder and current Chief Operations Officer (COO), ...
(Date:3/26/2015)... Massachusetts and CINCINNATI ... Shire plc (LSE: SHP, NASDAQ: SHPG ) ... a three-year, broad research collaboration for rare diseases. The ... develop novel therapies to treat rare diseases with ... commercialization capabilities with Cincinnati Children,s research expertise. As ...
(Date:3/26/2015)... "In America," the popular news television program that ... hosted by legendary film actor James Earl Jones, has announced ... upcoming segment. , Botany is commonly described as the ... quite a bit more complicated than that. Scientists and other ... organisms, from the smallest bacteria known to man to the ...
(Date:3/25/2015)... Agnition announced today that it will ... airing for the first time at 7:30 a.m. CST ... will explore the extremely important role soil microbes perform ... patented Microbial Catalystâ„¢ technology that enhances soil and plant ... will air again on April 28. , A biochemist ...
Breaking Biology Technology:PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 2PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 3Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 2Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 3Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 4Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 5Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2
... Wisconsin attracts far fewer defense research dollars annually than ... public and private initiatives are quietly positioning the state ... ,These projects and others like them could thrive as ... to the unique threats it poses. Tom Still, president ...
... - When scientists look back at this early period ... the hype surrounding this controversial research, but they won't ... cells from embryos of contributing to it. , ,Outlining ... University of Wisconsin-Madison professor James Thomson took ...
... - Wisconsin's role in tackling the world's most worrisome ... 2006 annual conference of the Wisconsin Biotechnology and Medical ... Oct. 12 at the GE Healthcare Institute in ... Doyle and former Gov. Tommy Thompson, but session topics ...
Cached Biology Technology:Chippewa Valley firms land more defense work 2Chippewa Valley firms land more defense work 3Chippewa Valley firms land more defense work 4Chippewa Valley firms land more defense work 5Chippewa Valley firms land more defense work 6Chippewa Valley firms land more defense work 7Thomson lends perspective to stem cell expectations 2Thomson lends perspective to stem cell expectations 3Wisconsin's role in health a focus of biotech event 2Wisconsin's role in health a focus of biotech event 3
... Time- and temperature-controlled microwave oven ... and Antigen Retrieval of formalin-fixed, ... ease of use, high throughput ... high performance. When used in ...
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
...
Biology Products: