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Pitt-led international study identifies human enzyme that breaks down potentially toxic nanomaterials, opens door to novel drug delivery
Date:4/7/2010

es by capturing them and exposing them to the enzyme. They implanted a sample of nanotubes with antibodies known as immunoglobulin G (IgG), which made them specific neutrophil targets. After 12 hours, 100 percent of IgG nanotubes were degraded versus 30 percent of those without IgG. The researchers also tested the ability of macrophages, another white blood cell, to break down nanotubes, but after two days, only 50 percent of the tubes had degenerated.

In subsequent laboratory tests, lung tissue exposed to the degraded nanotubes for seven days exhibited negligible change when compared to unexposed tissue. On the other hand, tissue exposed to untreated nanotubes developed severe inflammation.


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Contact: Morgan Kelly
Mekelly@pitt.edu
412-624-4356
University of Pittsburgh
Source:Eurekalert

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