Navigation Links
Pitt-led international study identifies human enzyme that breaks down potentially toxic nanomaterials, opens door to novel drug delivery
Date:4/7/2010

PITTSBURGHAn international study based at the University of Pittsburgh provides the first identification of a human enzyme that can biodegrade carbon nanotubesthe superstrong materials found in products from electronics to plasticsand in laboratory tests offset the potentially damaging health effects of being exposed to the tiny components, according to findings published online in Nature Nanotechnology.

The results could open the door to the use of carbon nanotubes as a safe drug-delivery tool and also could lead to the development of a natural treatment for people exposed to nanotubes, either in the environment or the workplace, the team reported. The researchers found that carbon nanotubes degraded with the human enzyme myeloperoxidase (hMPO) did not produce the lung inflammation that intact nanotubes have been shown to cause. Furthermore, neutrophils, the white blood cells that contain and emit hMPO to kill invading microorganisms, can be directed to attack carbon nanotubes specifically.

"The successful medical application of carbon nanotubes rely on their effective breakdown in the body, but carbon nanotubes also are notoriously durable," said lead researcher Valerian Kagan, a professor and vice chair in the Department of Environmental and Occupational Health in Pitt's Graduate School of Public Health. "The ability of hMPO to biodegrade carbon nanotubes reveals that this breakdown is part of a natural inflammatory response. The next step is to develop methods for stimulating that inflammatory response and reproducing the biodegradation process inside a living organism."

Kagan and his research group led the team of more than 20 researchers from four universities along with the laboratory groups of Alexander Star, an assistant professor of chemistry in Pitt's School of Arts and Sciences, and Judith Klein-Seethharaman, an assistant professor of structural biology in Pitt's School of Medicine. Additional Pitt researchers inclu
'/>"/>

Contact: Morgan Kelly
Mekelly@pitt.edu
412-624-4356
University of Pittsburgh
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Pitt-led study identifies human enzyme that breaks down potentially toxic nanomaterials
2. Pitt-led team gets $5.6 million contract for heart assist device for infants and toddlers
3. Pitt-led researchers create quick, simple fluorescent detector for TB
4. International team of scientists describe first Cretaceous African amber deposit
5. BIO-key(R) International Taps JMR Worldwide for PR, IR and Strategic Communications
6. Smithsonian hosts 2010 International CAM Workshop in Panama
7. From international harbor to native habitat
8. UC Riverside to host 3-day international meeting on drought
9. BIO-key(R) International Biometric Accuracy Improved by More Than 23% as Reported in Recent NIST Testing
10. Leicesters internationally acclaimed genetics research involved in project into saffron production
11. BIO-key(R) International to Showcase Biometric Identification Technology at RSA Conference 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... of years has adapted to the arctic cold, and then ... dangerous for you. , This is happening to the small ... substance, called nonylphenol, comes from the use of certain detergents, ... endocrine disruptor, but when entering the worm it has another ... cells in its body from cold damage. , Enchytraeus ...
(Date:9/18/2014)... new GSA Bulletin study uses tree rings ... and Chaco Wash in northern New Mexico, USA. By ... and willow, investigators were able to precisely date arroyo ... combined this data with aerial imagery, LiDAR, longitudinal profiles, ... arroyos. , Arroyos are deep, oversized channels that have ...
(Date:9/18/2014)... can operate inside the bore of an MRI scanner ... research partnership program at Brigham and Women,s Hospital in ... in conjunction with real-time MRI images, can make prostate ... discomforting for the patient. The novel system also has ... precision. , Developed by a team of robotics engineers ...
Breaking Biology News(10 mins):Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5
... 2012 Researchers at the Translational Genomics Research Institute (TGen) ... to a less costly, less invasive and more accurate way ... a major complication of diabetes, high blood pressure and a ... by a progressive deterioration of the kidney,s ability to filter ...
... Biological Chemistry "Paper of the Week" by Wai Mun ... Center and the University of Minnesota reveals new insights into ... tumefaciens , the pathogen responsible for crown gall disease, a ... beets. The bacterium is parasitic: It infects ...
... you,re a male born to a father who,s a strong and enduring ... become a leader yourself, due to the wide range of social advantages ... old man isn,t a leader, other men in your community are more ... on you and showing you the ropes. Sound like ...
Cached Biology News:TGen method isolates biospecimens for treatment of kidney disease 2The old primates' club: Even male monkeys ride their fathers' coattails to success 2The old primates' club: Even male monkeys ride their fathers' coattails to success 3The old primates' club: Even male monkeys ride their fathers' coattails to success 4The old primates' club: Even male monkeys ride their fathers' coattails to success 5
(Date:9/19/2014)... Charlotte, NC (PRWEB) September 19, 2014 ... Certified Biobased Product Label for its Organic Cotton ... the product’s amount of renewable biobased ingredients meets or ... or intermediate materials composed in whole or in significant ... “This logo/label will allow our Organic cotton to be ...
(Date:9/19/2014)... , September 19, 2014 ... and Markets ( http://www.researchandmarkets.com/research/b2jxhs/micro_market ) has announced the addition ... Chromatography Columns"  report to their offering.  ... market is one of the fastest-growing segments in ... $1.2 billion in 2013, and expected to reach ...
(Date:9/19/2014)... LONDON , September 19, 2014 ... Spain , available today on PharmaBoardroom.com ... of the Eurozone crisis that rocked the Spanish economy in ... the Spanish pharma community has remained pragmatic in times of ... is still the fifth biggest European market, and the ...
(Date:9/18/2014)... Austin, TX (PRWEB) September 18, 2014 ... of integrated urological and interventional radiology products and ... (also known as cryotherapy and cryoablation) versus external ... Mid-Atlantic Section of the American Urological Association (MAAUA) ... , "Comparing Relative Effectiveness of Cryosurgery and ...
Breaking Biology Technology:Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2Micro Market Monitor : Global Pre-packed Chromatography Columns 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2
... 8 The Alzheimer,s Drug Discovery Foundation (ADDF) and ... biotechnology industry and academia worldwide to apply for a new ... Research Award . The goal of the program is ... early diagnosis, detection and disease monitoring of Lewy body dementias. ...
... ... Facility , ... Pa. (Vocus) September 8, 2009 -- BPG Properties, Ltd. (BPG), one of ... , a 705,000 square foot highly specialized research and development/manufacturing facility in Lansdale, Pennsylvania ...
... LONDON, Sept. 8 PriceSpective, a value ... and biotechnology companies, is pleased to announce that it has ... Colasante, as a Vice President, and Sophie Murdoch, as a ... and expand its current offerings. , , ...
Cached Biology Technology:Alzheimer's Drug Discovery Foundation and the Lewy Body Dementia Association Invite Scientists to Apply for LBD Grant Award Program 2BPG Properties, Ltd. Announces 2750 Morris Road in Lansdale, Pennsylvania is for Sale 2BPG Properties, Ltd. Announces 2750 Morris Road in Lansdale, Pennsylvania is for Sale 3PriceSpective Appoints Colasante as a Vice President and Murdoch as a Director 2
... the membrane-permeant ester forms (CCF2-AM and ... beta-lactamase substrates, CCF2 and CCF4. These ... where cleavage by endogeneous cytoplasmic esterases ... charged forms, thereby trapping them in ...
...
Homogenizing Solution, 18ml Proteinase K - [50ug/l] 75 l...
...
Biology Products: