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Pitt gets $12 million DoD contract for regenerative medicine treatment trials
Date:5/25/2010

PITTSBURGH, May 25 A two-year, $12 million contract with the U.S. Department of Defense Office of Technology Transition (OTT) will jumpstart human trials of three innovative research programs that aim to replace scars and defects with healthy, functional tissues, announced officials of the University of Pittsburgh and the McGowan Institute for Regenerative Medicine today at the Institute's Second Annual Open Session, Soldiers and Sailors Memorial Hall, Oakland.

The OTT mission emphasizes the rapid translation of preclinical research into human studies to bring successful therapies more quickly to everyday practice, said Alan Russell, Ph.D., director of the McGowan Institute, a joint effort of Pitt and the University of Pittsburgh Medical Center (UPMC), and leader of the new program.

"This initiative provides fiscal support and also represents a shared commitment to the goal of helping soldiers return to the lives they have put on the line for us," he said. "All these projects could deliver much-needed solutions for the ills that plague our wounded warriors. They are designed to give back what has been lost or taken away: normal tissues that function properly, adapting to our changing biological environment to keep us healthy and whole."

In particular, the OTT initiative will focus on efforts to:

  • Replace muscle tissue through extracellular matrix, a protein- and growth factor-rich biological scaffold that appears to recruit stem cells and other precursors to injury sites; primary investigators Stephen Badylak, D.V.M., M.D., Ph.D., deputy director, McGowan Institute and J. Peter Rubin, M.D., Pitt School of Medicine

  • Bring to clinical testing an injectable, porous bone cement for the repair of craniofacial bone defects and restoration of normal bone growth and remodeling; primary investigators Bernard J. Costello, D.M.D., M.D., Pitt School of Dental Medicine; Prashant N. Kumta, Ph.D., Edward R. Weidlein
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Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

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