Navigation Links
Pitt/UPMC: Exceptional cognitive and physical health in old age leaves immunological fingerprint
Date:10/21/2011

PITTSBURGH, Oct. 20 Exceptional cognitive and physical function in old age leaves a tell-tale immunologic fingerprint, say researchers at the University of Pittsburgh and Children's Hospital of Pittsburgh of UPMC. Likewise, older adults who have mild impairments bear a distinct immunologic pattern, too, according to findings published today in the Public Library of Science: One.

Old age is not synonymous with impairment and disability, noted lead investigator Abbe N. de Vallejo, Ph.D., associate professor of pediatrics and immunology, University of Pittsburgh School of Medicine.

"Our study indicates that getting older does not necessarily mean that the immune system gets weaker, as many of us assumed," he said. "The immune system is dynamic, and the changes it undergoes over time very much influence function."

For the project, the team collected blood samples from 140 participants who had been followed in the Cardiovascular Health Study (CHS) for nearly two decades and were 78 to 94 years old. With only two participants younger than 82, the average age of the group was 86. The team also gathered information about the participants' health and function, medical history and hospitalizations, and self-rated health, and assessed their cognitive and physical function using standard tests.

Previous research has shown that with age, immune cells called T-cells become more like natural killer (NK) cells, which typically target tumor cells and virus-infected cells, Dr. de Vallejo said. A closer look in the new study shows that participants who were most physically and cognitively resilient had a dominant pattern of stimulatory NK receptors on the T-cell surface, and that these unusual T-cells can be activated directly through these NK receptors independently of the conventional ones. The functionally resilient elders also have a distinct profile of blood proteins called cytokines that reflect an immune-enhancing environment.<
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wide heads give hammerheads exceptional stereo view
2. New research explains autistics exceptional visual abilities
3. Research finds older women who are more physically fit have better cognitive function
4. Results from trials of DHA in Alzheimers disease and age-related cognitive decline
5. A heart healthy diet and ongoing, moderate physical activity may protect against cognitive decline
6. Supplementing babies formula with DHA boosts cognitive development
7. WIREs: Shaping the future of cognitive science
8. Fighting sleep, Penn researchers reverse the cognitive impairment caused by sleep deprivation
9. Consumption of certain fish during pregnancy associated with poorer cognitive performance
10. New study possibly links cognitive and motor delays with flat head syndrome in young babies
11. A common thread links multiple human cognitive disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... 2015 According to a new ... Assessment Type (Pen & Paper Based, Hosted, Biometrics), Service, ... Academic Research), Vertical and Region - Global Forecast to ... to grow from USD 2.4 Billion in 2015 to ... Growth Rate (CAGR) of 25.6% from 2015 to 2020. ...
(Date:8/20/2015)... 20, 2015 The wearable technology market ... active and healthy. However, wearable technology has the ... to help improve diagnostic capabilities and therapeutic outcomes. ... Wearable Technologies Conference 2015 , where ... wearables in healthcare.    "Over the ...
(Date:8/18/2015)... , Aug. 17, 2015 Research ... addition of the "Global Biometric Authentication & ... - Estimation & Forecast, 2015-2020" report to ... authentication and identification systems market is expected to ... 2015 to 2020 and generate over $25 billion ...
Breaking Biology News(10 mins):Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2
... have presented a Canadian-based UN coral reef specialist with ... marine research. Peter Sale, Assistant Director for Coastal ... Water, Environment and Health, and Emeritus Professor at the ... Excellence in Indo-Pacific ichthyology at the 8th Indo-Pacific Fish ...
... Scientists at Jefferson Medical College have received a ... by the National Institute of Arthritis and Musculoskeletal and ... and differentiation with the aim of regenerating diseased and ... group showed that stem cells exist in both animal ...
... , , , , , ... AUDIO: Barry Alto describes his research on the interactions of predators and prey. This is the audio for ... , , , , , ... , , , , , , , In a drama played out ...
Cached Biology News:Canadian-based UN coral reef expert honored at world meeting in Australia 2Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine 2Midge keeps invasive mosquito in check, aiding native mosquitoes 2Midge keeps invasive mosquito in check, aiding native mosquitoes 3Midge keeps invasive mosquito in check, aiding native mosquitoes 4
(Date:9/2/2015)... September 2, 2015 BioLight ... or the "Company"), a firm that invests in, ... cancer diagnostics, announced today that presentations highlighting its ... be delivered at the Ophthalmology Futures European Forum ... of Cataract & Refractive Surgeons ("ESCRS"), both taking ...
(Date:9/2/2015)... Biovista Inc. freut sich, ... 2015 bekanntgeben zu können. Hierbei handelt es sich ... Biovista unterstützt mit seiner Möglichkeit der Analyse ... Krankheiten als denen, für die ein Medikament ursprünglich ... Team bei der Wylder Nation Foundation bei der ...
(Date:9/2/2015)... ... 2015 , ... Whitehouse Laboratories is excited to announce that ... upcoming educational seminar and training session on Extractable & Leachable testing. Featuring a ... Updates & Case Studies on the Latest Compliance Implications of USP and ICH ...
(Date:9/2/2015)... ... September 02, 2015 , ... The ... creating professional commercial video content, to analysis of athletic performance. Producing high-resolution ... go by too quickly to process with the naked eye. , Slow ...
Breaking Biology Technology:Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 2Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 3Biovista sponsert die Forschung von Wylder Nation Foundation zum Thema Mangel an saurer Sphingomyelinase 2Whitehouse Laboratories to Participate in Pharm Ed Resources Extractables, Leachables, & Elemental Impurities Educational Seminar 2Whitehouse Laboratories to Participate in Pharm Ed Resources Extractables, Leachables, & Elemental Impurities Educational Seminar 3Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 2Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 3
... part of a new strategic plan featuring enhancements to ... has announced the launch of nonstop Midwest Connect ... serves Research Triangle Park , beginning June 1. ... hostile takeover bid by AirTran Holdings, noted that Raleigh/Durham ...
... NimbleGen Systems announced on Friday afternoon that it has ... and number of shares are yet to be determined. J.P. ... Partners, Leerink-Swann & Company and Robert W. Baird & Co. ... $12.5 million venture capital investment at the close of 2006 ...
... comes to health information technology, Greg Smith doesn't have to ... is thinking. , ,Smith, senior vice president and CIO ... the business side of the Wheaton shop. Armed with a ... resource business, and now sits on Hewlett Packard's ...
Cached Biology Technology:CIO Leadership Series: Greg Smith, Wheaton Franciscan Healthcare 2CIO Leadership Series: Greg Smith, Wheaton Franciscan Healthcare 3CIO Leadership Series: Greg Smith, Wheaton Franciscan Healthcare 4
GOAT ANTI HUMAN PARAINFLUENZA VIRUS 2+3...
... Cary 50 Microplate Reader accessory ... per analysis by extending the ... award-winning Cary 50 instruments. Use ... 384 samples in microlitre volumes, ...
IMAGEQUANT 300 WKSTN, 1 EA. Category: ImageQuant CCD Imagers....
PAb to Hu-IFN-Alpha/Beta R2 [(IFNAR2) CD118], Rabbit Serum, neutralizing Binds to but does not neutralize human interferon alpha/beta receptor...
Biology Products: