Navigation Links
Pitt/UPMC: Exceptional cognitive and physical health in old age leaves immunological fingerprint
Date:10/21/2011

PITTSBURGH, Oct. 20 Exceptional cognitive and physical function in old age leaves a tell-tale immunologic fingerprint, say researchers at the University of Pittsburgh and Children's Hospital of Pittsburgh of UPMC. Likewise, older adults who have mild impairments bear a distinct immunologic pattern, too, according to findings published today in the Public Library of Science: One.

Old age is not synonymous with impairment and disability, noted lead investigator Abbe N. de Vallejo, Ph.D., associate professor of pediatrics and immunology, University of Pittsburgh School of Medicine.

"Our study indicates that getting older does not necessarily mean that the immune system gets weaker, as many of us assumed," he said. "The immune system is dynamic, and the changes it undergoes over time very much influence function."

For the project, the team collected blood samples from 140 participants who had been followed in the Cardiovascular Health Study (CHS) for nearly two decades and were 78 to 94 years old. With only two participants younger than 82, the average age of the group was 86. The team also gathered information about the participants' health and function, medical history and hospitalizations, and self-rated health, and assessed their cognitive and physical function using standard tests.

Previous research has shown that with age, immune cells called T-cells become more like natural killer (NK) cells, which typically target tumor cells and virus-infected cells, Dr. de Vallejo said. A closer look in the new study shows that participants who were most physically and cognitively resilient had a dominant pattern of stimulatory NK receptors on the T-cell surface, and that these unusual T-cells can be activated directly through these NK receptors independently of the conventional ones. The functionally resilient elders also have a distinct profile of blood proteins called cytokines that reflect an immune-enhancing environment.<
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wide heads give hammerheads exceptional stereo view
2. New research explains autistics exceptional visual abilities
3. Research finds older women who are more physically fit have better cognitive function
4. Results from trials of DHA in Alzheimers disease and age-related cognitive decline
5. A heart healthy diet and ongoing, moderate physical activity may protect against cognitive decline
6. Supplementing babies formula with DHA boosts cognitive development
7. WIREs: Shaping the future of cognitive science
8. Fighting sleep, Penn researchers reverse the cognitive impairment caused by sleep deprivation
9. Consumption of certain fish during pregnancy associated with poorer cognitive performance
10. New study possibly links cognitive and motor delays with flat head syndrome in young babies
11. A common thread links multiple human cognitive disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... , Dec. 22, 2014  The 2014 ... the biometrics industry as Acuity Market Intelligence reports ... may finally be open. Acuity forecasts that intensifying ... devices that incorporate biometrics will drive a global ... billion biometric devices by 2020.   ...
(Date:12/19/2014)... 18, 2014  23andMe, Inc., the leading personal genetics ... pinpoints fine-scale differences in genetic ancestry of individuals from ... Since immigrants first arrived more than four hundred ... has served as a meeting place for peoples from ... the ongoing mixing of peoples with African, European, and ...
(Date:12/17/2014)... , Dec. 15, 2014 The ... make it easier to detect and prevent counterfeit ... Today the agency started performing an in-house ... will validate the authenticity of purchased microcircuits while ... new quality control measures will be conducted at ...
Breaking Biology News(10 mins):First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... little water available for plants to grow, their roots ... growth even under water-limiting conditions, according to research published ... University of Milan, Italy in the open access journal ... and soil microbial communities are critical to the health ...
... aerosol particles and the wavelength distribution of incident light ... and cools the local atmosphere, absorbs radiation and warms ... good handle on dust,s primary effect of reflecting and ... absorbing and warming at the longer infrared wavelengths has ...
... more than 1,000 people whose homelands stretch from Africa ... compiled the largest and most detailed catalog yet of ... researchers find the genetic roots of rare and common ... involved some 200 scientists at Washington University School of ...
Cached Biology News:Dust's warming counters half of its cooling effect 2Dust's warming counters half of its cooling effect 3Dust's warming counters half of its cooling effect 4Global genome effort seeks genetic roots of disease 2Global genome effort seeks genetic roots of disease 3
(Date:12/24/2014)... , Dec. 23, 2014 China Biologic ... "Company"), a leading fully integrated plasma-based biopharmaceutical company ... that its majority-owned subsidiary, Shandong Taibang Biological Products ... certification from the China Food and Drug Administration ... facility. As previously disclosed in the Company,s public ...
(Date:12/24/2014)... and NEW YORK , Dec. 23, ... open-label pilot study of mazindol in children with attention ... Therapy in December 2014 . The ... children with attention deficit/hyperactivity disorder" ( Konofal et al, ... Dec 1;8:2321-2332. eCollection 2014 ) shows that mazindol ...
(Date:12/22/2014)... 2014 GenomeDx Biosciences today announced that a ... a genomic test for prostate cancer, was able to ... by radical prostatectomy without adjuvant therapy. Although rapid metastasis ... using tumor genomics to identify these men who have ... important advance. The study has been published online ...
(Date:12/19/2014)... Hershey, PA (PRWEB) December 19, 2014 ... a leading developer and manufacturer of needle-free injection ... an agreement with Immunomic Therapeutics, Inc. (“ITI”) for ... injection device with its LAMP™ vaccine platform. ... for an exclusive Worldwide license to the Biojector®-2000 ...
Breaking Biology Technology:China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3
... Tuesday, April 1, 2008 At 10:00 a.m. Eastern ... ... Alseres,Pharmaceuticals, Inc. (Nasdaq: ALSE ) today reported consolidated financial,results for ... http://www.newscom.com/cgi-bin/prnh/20070608/NEF043LOGO ), "2007 was a year of significant ...
... a drug,and diagnostic discovery company, today announced that Matthew ... on April 1st,2008. At the same date, Philippe Rousseau ... CEO is appointed., Philippe Rousseau has served as ... member of its Management Board since 2004. John Jaskowiak,who ...
... Spectros Corporation,(Portola Valley, CA) reported that 2007 year-over-year ... in the hospital for a,broadening array of applications ... was the first device approved by the FDA ... organs receive,insufficient oxygen. "We are pleased that hospitals ...
Cached Biology Technology:Alseres Pharmaceuticals, Inc. Reports 2007 Financial Results and Provides Company Highlights 2Alseres Pharmaceuticals, Inc. Reports 2007 Financial Results and Provides Company Highlights 3Alseres Pharmaceuticals, Inc. Reports 2007 Financial Results and Provides Company Highlights 4Alseres Pharmaceuticals, Inc. Reports 2007 Financial Results and Provides Company Highlights 5Alseres Pharmaceuticals, Inc. Reports 2007 Financial Results and Provides Company Highlights 6Alseres Pharmaceuticals, Inc. Reports 2007 Financial Results and Provides Company Highlights 7Alseres Pharmaceuticals, Inc. Reports 2007 Financial Results and Provides Company Highlights 8Alseres Pharmaceuticals, Inc. Reports 2007 Financial Results and Provides Company Highlights 9Alseres Pharmaceuticals, Inc. Reports 2007 Financial Results and Provides Company Highlights 10ExonHit Appoints a New Management Board 2ExonHit Appoints a New Management Board 3ExonHit Appoints a New Management Board 4Spectros Corporation Reports 2007 Year-Over-Year Sales Rise 36% 2