Navigation Links
Pitt/Iowa team finds cellular structural molecule can be toxic: Makes pneumonia worse
Date:9/20/2010

in gene were more likely to have severe pneumonia.

"This research was inspired by the knowledge that some people have a mutation in this protein, a condition called Byler's disease, and they are more likely to get pneumonia," Dr. Mallampalli noted.

In other experiments, mice with the gene mutation and pneumonia were treated with an engineered protein fragment that attached to the cardiolipin binding site, preventing the molecule from interacting with surfactant and ultimately reducing lung injury and improving survival.

"A similar strategy might work in people and could be a very useful option at a time when we have bacterial strains that are resistant to multiple antibiotics," said Mark Gladwin, M.D., chief of the Division of Pulmonary, Allergy and Critical Care Medicine, Pitt School of Medicine.

Dr. Mallampalli and his colleagues are now working on ways to deliver proteins into the lung that tightly bind cardiolipin with the goal of translating this approach for testing in pneumonia patients.


'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Duke team finds compounds that prevent nerve damage
2. Study finds genetic variant plays role in cleft lip
3. In a last stronghold for endangered chimpanzees, survey finds drastic decline
4. Brown scientist finds coastal dead zones may benefit some species
5. Study finds high mortality of endangered loggerhead sea turtles in Baja California
6. Yale journal finds nanomaterials may have large environmental footprint
7. UCSB study finds physical strength, fighting ability revealed in human faces
8. NJIT professor finds engineering technique to identify disease-causing genes
9. Grapes may aid a bunch of heart risk factors, animal study finds
10. NC State finds new nanomaterial could be breakthrough for implantable medical devices
11. Pitt research finds that low concentrations of pesticides can become toxic mixture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... of a sparrow-sized fossil from China challenges the commonly ... that gained the ability to fly. The birdlike fossil ... much rather the remains of a tiny tree-climbing animal ... the Dinosaur Museum in Blanding, Utah, and Alan Feduccia ... in Springer,s Journal of Ornithology . , The ...
(Date:7/9/2014)... by researchers at the NIH,s National Center ... collaborators to treat sickle cell disease has ... The drug candidate, Aes-103, is the first ... mechanism of sickle cell disease. Baxter now ... for regulatory approval and commercialization. , Sickle ...
(Date:7/9/2014)... inhibitors and N-methyl-D-aspartate receptor antagonists can alleviate ... to affect irreversible cognitive dysfunction and effectively ... Amyloid beta peptide (Aβ) vaccines reduced and ... (AD) transgenic mouse model, and significantly improved ... and his team, First Affiliated Hospital of ...
Breaking Biology News(10 mins):Researchers declassify dinosaurs as being the great-great-grandparents of birds 2First drug candidate from NIH program acquired by biopharmaceutical company 2First drug candidate from NIH program acquired by biopharmaceutical company 3First drug candidate from NIH program acquired by biopharmaceutical company 4
... -- Children exposed prenatally to tobacco smoke and during childhood ... to research done at Cincinnati Children,s Hospital Medical Center. ... cases in children between the ages of 8 and 15 ... This could translate into up to 800,000 children ...
... November 23, 2009 Agios Pharmaceuticals today announced that ... the mutated IDH1 gene has a novel enzyme activity ... discovery shows that the mutated form of IDH1 produces ... formation and malignant progression of gliomas, the most common ...
... all read studies about the health benefits of having a ... level, where amino acids known as cysteines are much more ... other cysteines. Now, researchers at the University of Michigan, ... system that protects single cysteines. The research appears in the ...
Cached Biology News:Exposure to lead, tobacco smoke raises risk of ADHD 2Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer 2Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer 3Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer 4Saving the single cysteine: New antioxidant system found 2
(Date:1/15/2014)... DTS Language Services, Inc . is pleased to announce ... organizations who need document translations. Clients will now have ... in advance with a selection of nearly 50 life science ... critical factor in clinical and scientific fields, and decrease the ...
(Date:1/15/2014)... 15, 2014 AudioNotch is the internet's ... for the treatment of tinnitus. Patients listen to sound ... over a period of weeks to months, their tinnitus volume ... two forms: Notched Music and Notched White Noise. Now, AudioNotch ...
(Date:1/14/2014)... January 14, 2014 Carahsoft and CDS ... January 23, 2014 at 2pm EST (11am PST), “Natural ... topic focuses on how technology can turn raw, heterogeneous ... for government agencies. The online webinar will last approximately ...
(Date:1/14/2014)... As pet owners drew up their lists of New Year,s resolutions ... care of my furry companion." Nowadays there are pet salons, dog ... to take the little canine or feline darlings along wherever mommy ... some pricey toys at the pet store. But anyone who has ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... team of scientists, led by a biomedical engineer at The ... first time that mathematical models created from data obtained ... unknown cellular mechanisms. This brings biologists a step closer to ... workings of the cell as readily as NASA engineers plot ...
... Texas at Austin have conducted a basic chemistry experiment in ... thousandth the diameter of a human hair. The nano-scale ... was required to see the experiment. Made from a ... a thread-like crystal (a nanowire) of germanium with a tiny ...
... , PURCHASE, N.Y., Oct. 15 Nutrition 21, Inc. ... nutritional supplements under the Iceland Health®, Chromax® and Diabetes ... improve cardiovascular health, enhance memory and reduce chronic joint ... and the full fiscal year ended June 30, 2009. ...
Cached Biology Technology:Scientists use math modeling to predict unknown biological mechanism of regulation 2Tiny test tube experiment shows reaction of melting materials at the nano scale 2Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 2Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 3Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 4Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 5Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 6
... system holds 48 x 0.2 ml tubes, or a ... fluorescence (470-500 nm) for each well, and a pair ... 540-700 nm). This item is a real-time upgrade for ... are 18 x 32 x 33 cm (W x ...
... FC 500 Series is a ... the most advanced technologies available. ... flexible testing, powerful software and ... help researchers optimize their overall ...
... Cellomics KineticScan™ Reader is Cellomics‘ ... Solutions for Cell-based Screening". The ... ability to do both temporal ... physiological processes, dynamic distribution and ...
... PULSin may be superior to transfection in ... transfection, with PULSin you can study lethal ... course of proteins in cells. Likewise, delivery ... than traditional RNA interference experiments. ,With ...
Biology Products: