Navigation Links
Pitt: A shot of young stem cells made rapidly aging mice live longer and healthier
Date:1/3/2012

PITTSBURGH, Jan. 3 Mice bred to age too quickly seemed to have sipped from the fountain of youth after scientists at the University of Pittsburgh School of Medicine injected them with stem cell-like progenitor cells derived from the muscle of young, healthy animals. Instead of becoming infirm and dying early as untreated mice did, animals that got the stem/progenitor cells improved their health and lived two to three times longer than expected, according to findings published in the Jan. 3 edition of Nature Communications.

Previous research has revealed stem cell dysfunction, such as poor replication and differentiation, in a variety of tissues in old age, but it's not been clear whether that loss of function contributed to the aging process or was a result of it, explained senior investigators Johnny Huard, Ph.D., and Laura Niedernhofer, M.D., Ph.D. Dr. Huard is professor in the Departments of Orthopaedic Surgery and of Microbiology and Molecular Genetics, Pitt School of Medicine, and director of the Stem Cell Research Center at Pitt and Children's Hospital of PIttsburgh of UPMC. Dr. Niedernhofer is associate professor in Pitt's Department of Microbiology and Molecular Genetics and the University of Pittsburgh Cancer Institute (UPCI).

"Our experiments showed that mice that have progeria, a disorder of premature aging, were healthier and lived longer after an injection of stem cells from young, healthy animals," Dr. Niedernhofer said. "That tells us that stem cell dysfunction is a cause of the changes we see with aging."

Their team examined a stem/progenitor cell population derived from the muscle of progeria mice and found that compared to those from normal rodents, the cells were fewer in number, did not replicate as often, didn't differentiate as readily into specialized cells and were impaired in their ability to regenerate damaged muscle. The same defects were discovered in the stem/progenitor cells isolated from very old mice.

"We wanted to see if we could rescue these rapidly aging animals, so we injected stem/progenitor cells from young, healthy mice into the abdomens of 17-day-old progeria mice," Dr. Huard said. "Typically the progeria mice die at around 21 to 28 days of age, but the treated animals lived far longer some even lived beyond 66 days. They also were in better general health."

As the progeria mice age, they lose muscle mass in their hind limbs, hunch over, tremble, and move slowly and awkwardly. Affected mice that got a shot of stem cells just before showing the first signs of aging were more like normal mice, and they grew almost as large. Closer examination showed new blood vessel growth in the brain and muscle, even though the stem/progenitor cells weren't detected in those tissues.

In fact, the cells didn't migrate to any particular tissue after injection into the abdomen.

"This leads us to think that healthy cells secrete factors to create an environment that help correct the dysfunction present in the native stem cell population and aged tissue," Dr. Niedernhofer said. "In a culture dish experiment, we put young stem cells close to, but not touching, progeria stem cells, and the unhealthy cells functionally improved."

Animals that age normally were not treated with stem/progenitor cells, but the provocative findings urge further research, she added. They hint that it might be possible one day to forestall the biological declines associated with aging by delivering a shot of youthful vigor, particularly if specific rejuvenating proteins or molecules produced by the stem cells could be identified and isolated.


'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-720-2058
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Related biology news :

1. Young conservation biologist receives National Geographics 10,000th grant
2. New UC campus attraction will provide a unique, natural environment for the areas youngest learners
3. New hope for young leukemia patients?
4. Research aims to prevent obesity by reaching parents, young children through child care
5. Hysterectomy increases risk for earlier menopause among younger women
6. 22 young researchers join the 2011 EMBO Young Investigator Program
7. Gene responsible for relapses in young leukemia patients
8. Smoking a single cigarette may have immediate effect on young adults
9. IOF Young Investigator Awards recognize research excellence at Dubai meeting
10. 2011 a banner year for young striped bass in Virginia
11. Young artists draw their healthy lifestyles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/26/2017)...  Crossmatch, a leading provider of security and identity ... combatting fraud, waste and abuse in assistance operations around ... on Disaster Relief conference in Panama City ... and foreign assistance organizations throughout Latin America ... a largely unacknowledged problem in the foreign assistance and ...
(Date:1/23/2017)... , Jan. 23, 2017  The latest mobile ... smartphone prices have dropped dramatically. The quarterly average price ... 2013 to $276 in Q4 2016.  There are now ... price of $116, up from just 28 a year ... According to Maxine Most , Acuity Market ...
(Date:1/18/2017)... 2017 MedNet Solutions , an ... entire spectrum of clinical research, is proud to ... for the organization in terms of corporate growth, ... products and services. The company,s exceptional achievements can ... iMedNet ™ – ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... Feb. 21, 2017  Lexus, a returning partner of the ... official and exclusive automobile partner of the men,s and women,s events ... The 2017 Amgen Tour of California ... some of the best professional cycling teams in the world racing ... The four-day Amgen Breakaway from Heart Disease TM ...
(Date:2/21/2017)... FRANCISCO , Feb. 21, 2017   Invitae ... genetic information companies, today announced that members of the ... Company 37th Annual Health Care Conference on Monday, March ... p.m. Pacific in Boston, Massachusetts . ... presentation may be accessed by visiting the investors section ...
(Date:2/20/2017)... , Feb. 20, 2017 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ) ... and CEO and Fabrice Orecchioni, the company,s COO, has been named ... over the past four years, Fabrice has overseen the construction, start-up ... and the management of the Mitsui JV.  Fabrice has also ... proposed China JV. ...
(Date:2/20/2017)... ... February 20, 2017 , ... Salford-based Mettler Toledo Safeline, which ... pharmaceutical processing and packaging industries, was runner-up for the Environmental Achievement Award, sponsored ... most or taken the most innovative steps to improve its environmental performance. ...
Breaking Biology Technology: