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Pioneers in Alzheimer's research: Research couple honored for its lifetime achievement
Date:7/16/2013

opped, the synapses regenerate and the mice recover from amnesia. This observation shows that the disease process is in principle reversible.

Eckhard Mandelkow: "I am of the opinion that an effective therapy against Alzheimer is possible. Crucial, in my view, is that the treatment is started early enough. Many of today's therapy approaches might have failed on account of the fact that they are applied too late. Since a disease is usually only diagnosed when typical symptoms such as memory dysfunctions are evident. At this time, the brain is however already severely damaged."

Recently, the couple has examined 200,000 substances, in order to find an active agent against the aggregation of tau. Some of these substances were found to be potential candidates for drugs. Their effect will now be further explored.

Prof. Dr. Eckhard Mandelkow studied physics and did his PhD at the Max Planck Institute for Medical Research in Heidelberg on the structure of virus proteins. In a subsequent research period at the Brandeis University (USA), he already dealt with proteins of the cytoskeleton and then continued this line of research. Then he focused on the structure and function of proteins of the nerve cells, especially of motor proteins, tau proteins and their pathological changes during the neurodegeneration. He is the head of the working group "Structural principles of neurodegeneration" at the DZNE/caesar in Bonn.

Dr. Eva-Maria Mandelkow studied medicine, worked for several years in the clinic and then pursued a career in fundamental research. She received her PhD at the Max Planck Institute for Medical Research in Heidelberg for her work in muscle physiology. This was followed by research periods at the Brandeis University (USA), the Scripps Research Institute (USA) and at the MRC Laboratory in Cambridge (UK), where she dealt with proteins of the cytoskeleton. Eva-Maria Mandelkow heads the working group "Cell and animal models of neurodegen
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Contact: Dirk Förger
presse@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

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