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Pinpointing genes that protect against frailty
Date:8/8/2014

ef="https://www.einstein.yu.edu/centers/aging/research/longenity-longevity-genes-projects/longenity.aspx">LonGenity Research Study, which builds upon the Longevity Genes Project, an ongoing 15-year study with more than 500 Ashkenazi Jews over the age of 95. LonGenity compares the genetics of the centenarians and their children with those with usual survival. Over the past 10 years, Dr. Barzilai's team has identified several biological markers that may explain their extreme longevity.

"We have shown that our centenarian participants have a significant genetic advantage over the general population. Their rare genetic variants have allowed them to live longer, healthier lives and avoid or significantly delay age-related diseases, such as Alzheimer's and type 2 diabetes," said Dr. Barzilai,. "We now want to know if a family history of those same 'longevity genes' reduces the risk for frailty."

The researchers will build on a pilot study funded by the American Federation for Aging Research that linked exceptional longevity to improved physical function and reduced risk of frailty. The Einstein team plans to further those initial efforts to identify gene variants that keep frailty at bay, explore biological pathways that may lead to frailty, and develop drugs that mimic the effect of those frailty-preventing genes.

The five-year grant, "Role of exceptional longevity genotypes in protection against frailty in aging" (R01AG044829), was awarded by the National Institute on Aging, part of the NIH.


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Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

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