Navigation Links
Pinpointing genes that protect against frailty
Date:8/8/2014

August 8, 2014 ─ (BRONX, NY) ─ Frailty is a common condition associated with old age, characterized by weight loss, weakness, decreased activity level and reduced mobility, which together increase the risk of injury and death. Yet, not all elderly people become frail; some remain vigorous and robust well into old-age. The question remains: why?

Researchers at Albert Einstein College of Medicine of Yeshiva University have been awarded a $3.3 million grant from the National Institutes of Health (NIH) to study the role of genetics in protecting against frailty. The study will be led by Nir Barzilai, M.D., director of the Institute for Aging Research and the Ingeborg and Ira Leon Rennert Chair in Aging Research at Einstein and attending physician, medicine at Montefiore Medical Center, and Joe Verghese, M.B.B.S., the Murray D. Gross Memorial Faculty Scholar in Gerontology at Einstein, chief of geriatrics at Einstein and Montefiore and director of the Montefiore Einstein Center for the Aging Brain.

"People who are frail are more vulnerable to serious complications from falls or surgery and more susceptible to infection," said Dr. Verghese. "Understanding why some elderly people do not experience a loss of balance or strength and do not suffer from abnormal gait may help us prevent and treat such physical decline."

The new project taps into the resources of Einstein's LonGenity Research Study, which builds upon the Longevity Genes Project, an ongoing 15-year study with more than 500 Ashkenazi Jews over the age of 95. LonGenity compares the genetics of the centenarians and their children with those with usual survival. Over the past 10 years, Dr. Barzilai's team has identified several biological markers that may explain their extreme longevity.

"We have shown that our centenarian participants have a significant genetic advantage over the general population. Their rare genetic variants have allowed them to live longer, healthier lives and avoid or significantly delay age-related diseases, such as Alzheimer's and type 2 diabetes," said Dr. Barzilai,. "We now want to know if a family history of those same 'longevity genes' reduces the risk for frailty."

The researchers will build on a pilot study funded by the American Federation for Aging Research that linked exceptional longevity to improved physical function and reduced risk of frailty. The Einstein team plans to further those initial efforts to identify gene variants that keep frailty at bay, explore biological pathways that may lead to frailty, and develop drugs that mimic the effect of those frailty-preventing genes.

The five-year grant, "Role of exceptional longevity genotypes in protection against frailty in aging" (R01AG044829), was awarded by the National Institute on Aging, part of the NIH.


'/>"/>
Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Related biology news :

1. Scientists discover how jumping genes help black truffles adapt to their environment
2. Butterflies could hold key to probes that repair genes
3. Neiker-Tecnalia is researching the potato genes that best adapt to climate change
4. High matrix metalloproteinase-9 expression induces microangiogenesis after cerebral infarction
5. Genetic risk for autism stems mostly from common genes
6. ADSCs transplantation promotes neurogenesis in Alzheimers disease
7. Sweet genes
8. A CNIO team reduces the size of the human genome to 19,000 genes
9. CNIO researchers discover more than 40 melanoma-specific genes that determine aggressiveness
10. Fruit flies help scientists uncover genes responsible for human communication
11. Schizophrenia and cannabis use may share common genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... , June 22, 2016   Acuant ... and verification solutions, has partnered with RightCrowd ... solutions for Visitor Management, Self-Service Kiosks and ... products that add functional enhancements to existing ... corporations and venues with an automated ID ...
(Date:6/15/2016)... June 15, 2016 Transparency ... titled "Gesture Recognition Market by Application Market - Global Industry Analysis ... 2024". According to the report, the  global gesture recognition ... 2015 and is estimated to grow at a ... by 2024.  Increasing application of gesture ...
(Date:6/2/2016)... , June 2, 2016 The ... has awarded the 44 million US Dollar project, for ... Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... leader in the production and implementation of Identity Management Solutions. ... January, however Decatur was selected for ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... 2016 , ... Parallel 6 , the leading software as a service ... Virtual Patient Encounter CONSULT module which enables both audio and video telemedicine communication ... , Using the CONSULT module, patients and physicians can schedule a face to face ...
(Date:6/27/2016)... , ... June 27, 2016 , ... ... for Amgen, will join the faculty of the University of North Carolina ... professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the ...
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
Breaking Biology Technology: