Navigation Links
Pinhead-size worms + robot = new antibiotics
Date:8/5/2009

In an advance that could help ease the antibiotic drought, scientists in Massachusetts are describing successful use of a test that enlists pinhead-sized worms in efforts to discover badly needed new antibiotics. Their study appeared in ACS Chemical Biology, a monthly journal.

Frederick Ausubel and colleagues note in the new study that existing methods for identifying germ-fighting drugs involve adding the potential drug to cultures of bacteria or cells and watching the results. These tests sometimes do not work well. They may give passing grades to potential drugs that are toxic, or that fight bacteria in the same ways as existing antibiotics that are loosing effectiveness against drug-resistant bacteria. A much better test would involve screening of potential new antibiotics in living animals infected with bacteria to see the effects on the entire body of the animal.

The scientists describe successful use of such a whole-animal high throughput screening test automated with a robot to test the effects of 37,000 potential drugs on C. elegans (a type of worm) infected with E. faecalis (a type of bacteria). That bacterium causes life-threatening infections in humans. C. elegans are tiny nematode worms that are widely used in scientific research. The tests identified 28 potential new drugs never before reported to have germ-fighting effects. Some of the potential new drugs worked in ways that appeared to be totally different than existing antibiotics.


'/>"/>

Contact: Michael Woods
m_woods@acs.org
202-872-6293
American Chemical Society
Source:Eurekalert  

Page: 1

Related biology news :

1. Scientists alter sexual orientation in worms
2. Drug commonly used to treat bipolar disorder dramatically increases lifespan in worms
3. Worms take the sniff test to reveal sex differences in brain
4. Snoozing worms help Penn researchers explain the evolution of sleep
5. After more than 100 years apart, webworms devastate New Zealand parsnips
6. Rusty worms in the brain
7. Rutgers biologist to study worms in Amazon, glaciers
8. Sex and lifespan linked in worms
9. Almost 7 million pregnant in sub-Saharan Africa infected with hookworms; at risk of anaemia
10. Longevity, cancer and diet connected: New research in worms could apply to humans
11. Floridas worm grunters collect bait worms by inadvertently imitating mole sounds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pinhead-size worms + robot = new antibiotics
(Date:9/2/2014)... September 2, 2014 A study published in ... of the American Academy of Child and Adolescent ... with a psychiatric diagnosis had an increased risk ... antipsychotics. , Using data from the nationwide Danish ... Ren Ernst Nielsen, Psychiatry, Aalborg University Hospital, Denmark, ...
(Date:9/2/2014)... of lithographic limestone is well known as a ... that area (for example, Archaeopteryx). Now, for the ... the French equivalent of these outcrops - discoveries ... known water treader. , Despite the abundance of ... have been obtained from the Late Kimmeridgian equivalents ...
(Date:9/1/2014)... in the U.S. has improved steadily in recent yearsspurred ... dietary quality remains poor and disparities continue to widen ... study from Harvard School of Public Health (HSPH). , ... that the extensive efforts by many groups and individuals ... but it also indicates that these efforts need to ...
Breaking Biology News(10 mins):Risk of diabetes in children and adolescents exposed to antipsychotics 2Exceptionally well preserved insect fossils from the Rhône Valley 2Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3
... in German . It,s a quick process, ... seconds, a laser beam has welded the casing and speedometer cover ... is a perfect weld seam scarcely visible to the naked eye. ... welding. What,s more: the resulting heat is confined to a minimal ...
... Columbia have been able to pinpoint more of the ... valuable compounds to the roasting process. Lead author ... the prevailing antioxidants present in dark roasted coffee brew ... high temperatures. Their findings will appear in ...
... of Zaragoza (UNIZAR) has studied precipitation trends in Spain,s ... The results show that precipitation has declined overall between ... of the rainy season. The rains are heavier in ... ,Since 1946, the average precipitation falling on Spanish hydrological ...
Cached Biology News:Laser welding in the right light 2Roasting coffee beans a dark brown produces valued antioxidants: UBC food scientists 2Rain in Spain is on the decline 2
(Date:9/1/2014)... Albany, NewYork (PRWEB) September 01, 2014 ... Pharma, Biotech and Diagnostics report provides comprehensive understanding ... and agreements entered into by the worlds leading ... detailed understand and analysis of how and why ... flexibility of a prospective partner’s negotiated deals terms ...
(Date:8/31/2014)... 31, 2014 2014 Market ... a professional and in-depth research report on ... Polyacrylamide information, including Polyacrylamide definition, classification, application, ... industry overview. This research covers the international ... as global industry analysis covering macroeconomic environment ...
(Date:8/29/2014)... SAN DIEGO, Aug. 29, 2014  Pfenex Inc. ... in the development of high-value and difficult to ... business update and reported financial results for the ... "With the successful completion of our initial public ... advance our biosimilar product candidates, derived from our ...
(Date:8/29/2014)... According to a new market report published by Transparency ... valued at USD 3,754.6 million in 2012 and is estimated ... CAGR of 5.9% from 2013 to 2019. , Nearly half ... by bone and joint disorders, and this number is expected ... will continue to increase the demand for orthobiologics. Other factors ...
Breaking Biology Technology:Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3
... Researcher Provides Extensive Experience In Molecular DiagnosticsSALT LAKE ... company revolutionizing spine care through the development of ... Macina, Ph.D., has joined the executive management team ... and Development. Dr. Macina will report directly to ...
... Feb. 24 Innovative Biosensors, Inc., and ProGenTech ... diagnostics, today announced an agreement to jointly develop ... incorporate Innovative Biosensor,s proprietary Cellular Analysis and Notification ... cell-based approach for quickly detecting various pathogens, into ...
... the gene that ultimately controls the production of tooth ... to the repair of damaged enamel, a new concept ... of replacement teeth. , The gene, called Ctip2, is ... several functions - in immune response, and the development ...
Cached Biology Technology:Axial Biotech Appoints Dr. Roberto Macina to Vice President of Research and Development 2Innovative Biosensors and ProGenTech Partner to Develop a Rapid Diagnostics System 2Innovative Biosensors and ProGenTech Partner to Develop a Rapid Diagnostics System 3Genetic discovery could lead to advances in dental treatment 2
... designed to rapidly and reliably amplify unknown ... Technology. APAgene provides hassle-free, ready-to use components, ... ingredients are provided in each kit. The ... gap filling, localized cloning of genomic DNA, ...
No description available in Ensembl. Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Rabbit polyclonal to Yaf9 ( Abpromise for all tested applications)....
... is designed to deparaffinize and perform Heat ... paraffin-embedded tissue sections mounted on glass microscope ... paraffin at the high temperature used in ... of the paraffin by detergent. Formaldehyde fixation ...
Biology Products: