Navigation Links
Pinch away the pain
Date:2/16/2010

Scorpion venom is notoriously poisonous ― but it might be used as an alternative to dangerous and addictive painkillers like morphine, a Tel Aviv University researcher claims.

Prof. Michael Gurevitz of Tel Aviv University's Department of Plant Sciences is investigating new ways for developing a novel painkiller based on natural compounds found in the venom of scorpions. These compounds have gone through millions of years of evolution and some show high efficacy and specificity for certain components of the body with no side effects, he says.

Peptide toxins found in scorpion venom interact with sodium channels in nervous and muscular systems ― and some of these sodium channels communicate pain, says Prof. Gurevitz. "The mammalian body has nine different sodium channels of which only a certain subtype delivers pain to our brain. We are trying to understand how toxins in the venom interact with sodium channels at the molecular level and particularly how some of the toxins differentiate among channel subtypes.

"If we figure this out, we may be able to slightly modify such toxins, making them more potent and specific for certain pain mediating sodium channels," Prof. Gurevitz continues. With this information, engineering of chemical derivatives that mimic the scorpion toxins would provide novel pain killers of high specificity that have no side effects.

An ancient Chinese secret?

In his research, Prof. Gurevitz is concentrating on the Israeli yellow scorpion, one of the most potent scorpions in the world. Its venom contains more than 300 peptides of which only a minor fraction has been explored. The reason for working with this venom, he says, is the large arsenal of active components such as the toxins that have diversified during hundreds of millions of years under selective pressure. During that process, some toxins have evolved with the capability to directly affect mammalian sodium channel subty
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A tiny pinch from a z-ring helps bacteria cells divide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... 2015 In Brazil , cloud ... using these solutions and 42 percent planning to invest in ... 25 percent of the companies will be investing in these ... of companies in the region are currently opting for the ... will command significant attention in the coming years. This trend ...
(Date:3/2/2015)... March 2, 2015 Synaptics Inc. (NASDAQ: ... human interface solutions, today announced a new implementation ... to enable rapid and secure transactions and reliable ... gaming is a turnkey solution providing mouse and ... quickly integrate fingerprint ID solutions into their product ...
(Date:2/25/2015)... 25, 2015  ABC Financial Services (ABC), the ... Health and Fitness Industry, today announced enhancements to ... The latest upgrade includes advances to the agreement ... check-in via Identity One fingerprint biometrics. The features ... interactive displays at the International Health, Racquet & ...
Breaking Biology News(10 mins):Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 4Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3
... Personal health recommendations and diets tailored to better ... focusing on genetics. Researchers at Kansas State University ... for nutrigenomics, a field that studies the effects of ... of using food to prevent an individual,s genes from ...
... for Experimental Biology and Medicine has established the ... seminal research accomplishments have established them as leaders ... to SEBM. The following Past Presidents of ... recipients of the SEBM Distinguished Scientist Award. ...
... and THE WOODLANDS, Texas March 5, 2010 ... that it is collaborating with the Translational Genomics ... the genomes of 14 patients afflicted with triple ... multiple other therapies. The goal of this first-of-its-kind ...
Cached Biology News:Studies on nutrients, gene expression could lead to tailored diets for disease prevention 2Studies on nutrients, gene expression could lead to tailored diets for disease prevention 3Life Technologies, TGen and US Oncology partner on groundbreaking breast cancer sequencing research 2Life Technologies, TGen and US Oncology partner on groundbreaking breast cancer sequencing research 3
(Date:3/26/2015)... March 26, 2015 ReliantHeart, Inc., an ... Transonic, a supplier of precision transit-time flow measurement solutions, ... greatly improve the efficiency of the HeartAssist5® ... patients to experience greater mobility and peace of mind. ... miniature flow board, will draw 1/6th of the power ...
(Date:3/26/2015)... March 26, 2015 WriteResult, a premier ... researchers from Yale University’s School of Public Health and ... participants during a 4 month-long project. The goal of ... low income families with free access to fresh produce ... diet-related health concerns like high blood pressure, diabetes and ...
(Date:3/25/2015)... TORONTO , March 25, 2015 /PRNewswire/ - SQI Diagnostics ... announced that, as a result of recent discussions with ... common shares of the Company, after dealing with certain ... and special meeting of shareholders on March 26, 2015 ... that the election of directors will take place when ...
(Date:3/25/2015)... March 25, 2015  S&P Capital IQ (MHFI) ... Stock Report coverage on Abattis Bioceuticals Corp . ... ATT): is a specialty biotechnology company with capabilities ... and marketing proprietary ingredients, bio-similar compounds, patented equipment ... North America . The company seeks ...
Breaking Biology Technology:LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 2SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 4SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 5S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 5
... Inc., a,biopharmaceutical company engaged in the discovery and ... diseases, announced today,that it has been named to ... one of the top biotech companies of 2008. ... based on company,vision, revenue potential, quality of deals, ...
... CXM ) announced today that it has ... according to the preliminary list of additions,issued by ... the,Russell Indexes will take place after the market ... http://www.newscom.com/cgi-bin/prnh/20051018/CARDIUMLOGO ), Annual reconstitution of Russell,s U.S. ...
... Research & Development Team, CLINTON, N.J., ... fully,integrated critical care biotherapeutics company, announced that ... President of Translational,Medicine, reporting to Ralf Rosskamp, ... of Ikaria., As Vice President of ...
Cached Biology Technology:Tolerx Named as One of the 'Fierce 15' Biotech Companies of 2008 2Tolerx Named as One of the 'Fierce 15' Biotech Companies of 2008 3Cardium Selected for Inclusion in Russell Microcap Index 2Cardium Selected for Inclusion in Russell Microcap Index 3Cardium Selected for Inclusion in Russell Microcap Index 4Ikaria Introduces Dr. Michael Cooreman as Vice President of Translational Medicine 2Ikaria Introduces Dr. Michael Cooreman as Vice President of Translational Medicine 3
... is a software package that provides ... for custom buffer creation, set-up of ... crystallization trials. The software helps crystallographers ... automated protein crystallography: ...
BD Falcon insert HTS 96 well, square A-bottom with lid. PET membrane, sterile. (5/ca) Packaging: 5 / pack, 5 / case ...
... plate, Directly compatible with ABI thermal cyclers, ... improved sealing characteristics can be sealed ... cap strips, Certified free of DNase, RNase ... of Thermo Fisher Scientific, the world leader ...
Vented Caps for 75 cm2 Flasks...
Biology Products: