Navigation Links
Pigs and dogs can bridge gap between mice and humans in developing new therapies
Date:12/16/2008

d drug development, including new medical technologies, devices and interventions. Large animals could also be used for research in a number of disease categories, including cancer, metabolic disorders such as obesity, and regenerative therapies, such as use of stem cells to replace damaged heart muscle.

The workshop focused particularly on pigs and dogs because these two animals are quite similar in scale and anatomy to humans, while serving quite complementary functions. Dogs could be used as models for studying the immediate consequences of infectious disease, while pigs could be genetically engineered to mimic certain human conditions, such as deficiencies in the immune system. In such cases pigs would be used like mice are at present to model certain aspects of human immunity or metabolic disorder, but with the advantage of being closer to us in many respects.

"A possible idea is the generation of pigs with a humanised immune system," said Schnieke. "The proof of principle has been shown in the mouse. Immune-deficient mice can be reconstituted with human immune cells and can be used to study immune reactions, for example against tissue xenografts (transplantation of tissue between species, such as pig to human). In theory this could also be possible in pigs. Therefore the generation of immune-deficient pigs is an important goal."

But further funding is required to develop suitable pig models, possibly within a European pig clinic. The workshop also discussed setting up smaller collaborative projects focussed on specific disease areas, with a view to obtaining funding from the ESF. A task force was established to pursue these goals.


'/>"/>

Contact: Angelika Schnieke
schnieke@wzw.tum.de
49-816-171-2004
European Science Foundation
Source:Eurekalert

Page: 1 2

Related biology news :

1. Building bridges between the clinic and the laboratory
2. Researchers bridge the terahertz gap with new tunable metamaterial
3. Truck-safe bamboo bridge opens in China
4. Scientists find link between inflamed gums and heart disease
5. U of Minnesota researcher finds link between aggression, status and sex
6. Adiponectin is a metabolic link between obesity and bone mineral density
7. Tiny protein provokes healthy bonding between cells
8. Escherichia coli bacteria transferring between humans and mountain gorillas
9. Researchers find link between nicotine addiction and autism
10. Balance between traditional activities, tourism key to sustaining coastal Alaska communities
11. MSU researcher studies ties between cholesterol drugs, muscle problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... – (Nov. 4, 2014) – A majority of Madagascar,s ... that could have serious consequences for the rainforests they ... shows the positive impacts lemurs can have on rainforest ... their disappearance could have on the region,s rich biodiversity. ... have fruits eaten by lemurs. Lemurs in turn ...
(Date:11/3/2014)... Colorado Cancer Center study published in this ... describes the activity of a recently discovered communication ... IL-37. It has been known to limit inflammation and ... immune system: IL-37 inhibits the ability of the immune ... this mechanism that underlies IL-37,s effect on the immune ...
(Date:11/2/2014)... In this month,s issue of Physics World , ... bridging the "valley of death" to take their innovations ... argues that the gruelling challenge facing all start-up companies ... harder for physicists because of two main factors: physics-based ... and they often turn out to be a lot ...
Breaking Biology News(10 mins):Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3PNAS: From HIV to cancer, IL-37 regulates immune system 2The 'valley of death' facing physics start-ups 2
... A new species of monkey flower, created by the ... bank of a stream in Scotland. Genetic changes in this attractive ... a rare example of a brand new species that has originated ... species and some crops are thought to have originated in this ...
... Calif.) Despite the ever-louder drumbeat for sustainability and ... a collision course with "unprecedented levels of damage and ... assessment that includes UC Santa Barbara researchers among its ... Global Environmental Outlook report commonly known as GEO-5 ...
... occurring protein called TLR1 plays a critical role in ... pork or drinking contaminated water, according to new research ... discovery may help create more effective oral vaccines for ... has launched an examination of how TLR1 is linked ...
Cached Biology News:Rare glimpse into the origin of species 2UC Santa Barbara researchers play key role in UN Environmental Assessment 2UC Santa Barbara researchers play key role in UN Environmental Assessment 3TLR1 protein drives immune response to certain food-borne illness in mice 2
(Date:11/26/2014)... 25, 2014 Silicon Valley Electronic Data ... RPM Alliance , provider of clinical research and ... the latest addition to its CRO Partnership Program, Clinovo ... system to India. , “We have found Clinovo’s ... customizable EDC platform which is both user friendly and ...
(Date:11/26/2014)... SoundConnect , an award winning ... announce that Darren Suders has joined the team as ... drive the partner program through innovative offerings, ... , Darren brings more than 10-years of channel telecommunication ... channel operations, from policy development, to partner education and ...
(Date:11/26/2014)... novembre 2014 /PRNewswrie/ -- Theravalues Corporation annuncia con orgoglio ... in occasione di Hi Europe 2014 (dal 2 al ... Si tratta della curcumina con la maggiore biodisponibilità di ... e ingredienti approvati dalle norme europee. La ... pianta curcumina ( Curcuma longa ) che è stata ...
(Date:11/24/2014)... , Belgium , Nov. 24, 2014 ... sciences company focused on developing diagnostic tests for cancer and ... cancer study will be presented at the Science for Business ... Belgium . The data come from VolitionRx,s ... at the Pneumology department of the Centre Hospitalier Universitaire (CHU) ...
Breaking Biology Technology:RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2SoundConnect Appoints Director of Channel Development & Sales 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6
... millions of Americans whose vision is slowly ebbing due to degenerative ... riding to the rescue. , ,In a study in rats, neural ... to protect the vision of animals with degenerative eye disease similar ... appears in the journal Public Library of Science (PLoS) ...
... the launch of a new laptop-sized ultrasound system, ... in the compact ultrasound industry in 2006, according to ... Consultants . , ,Klein Biomedical, which tracks ultrasound market ... of the compact ultrasound market, with annual sales of ...
... Madison, Wis. - Gov. Jim Doyle has announced the allocation ... new ethanol plant in the Juneau County village of Necedah. , ... help Necedah construct a new well and water main that will ... will produce 50 million gallons of ethanol annually and employ between ...
Cached Biology Technology:Stem cell therapy shows visionary promise 2Stem cell therapy shows visionary promise 3GE Healthcare leads compact ultrasound market 2
... and temperature control for microbiology and cell ... and is suitable for DASGIP bioreactors from ... Its temperature ranges from approximately 10 °C ... equipped with an individual electrical heating element ...
... records analyzes and reports the data from any ... the a chart recorder. The final data is ... The end-point selection is automatic for Systolic, Mean, ... computed. The user is always in the position ...
... Custom DNA microarrays designed for your ... and powerful Paraflo microfluidic synthesis platform. Thousands ... on-chip and LC Sciences can provide assistance ... available as part of our comprehensive Custom ...
... aptamer screening and binding optimization and built ... on-chip synthesis platform. These microarrays are available ... Microarray Service. Probe Content ... greater than 1500 known aptamer sequences. Add ...
Biology Products: