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Physics strategy tested as solution for antibiotic resistance
Date:4/21/2010

tics cued to protein fluctuations in persister cells. Their finding that resonant activation fluctuating antibiotic treatments accelerates bacteria colony sterilization was published in the journal Physical Biology in March 2010 ("Resonant activation: a strategy against bacterial persistence," Fu, Zhu, and Xing. http://iopscience.iop.org/1478-3975/7/1/016013).

Xing acknowledges that that the computer simulation simplified the problem by neglecting further complication due to mutation, but said he believes the concept has applications for cancer treatment. "On and off dosing with chemicals could be as effective as or more effective than long-term dosage. You need to stop and let the body recover, then resume," he said.

He is particularly interested in conducting experiments to see if resonant activation could increase the efficiency of inducing a normal (somatic) cell into an undifferentiated or stem cell.

"Bacteria mutate quickly, but there could be applications for cancer or stem cell conversion, where mutation is slower or not an issue," Xing said.


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Contact: Susan Trulove
strulove@vt.edu
540-231-5646
Virginia Tech
Source:Eurekalert

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