Navigation Links
Physicists decode decision circuit of cancer metastasis
Date:10/24/2013

allow tumor cells break away, migrate to other parts of the body and establish a new tumor. To find ways to shut down metastasis, cancer researchers have conducted dozens of studies about the genetic circuitry that activates the EMT.

One clear finding from previous studies is that a two-component genetic switch is the key to both the EMT and MET. The switch contains two specialized pairs of proteins. One pair is SNAIL and microRNA34 (SNAIL/miR34), and the other is ZEB and microRNA200 (ZEB/miR200).

Each pair is "mutually inhibitory," meaning that the presence of one of the partners inhibits the production of the other.

In the mesenchymal cell state -- the state that corresponds to cancer metastasis -- both SNAIL and ZEB must be present in high levels. In the epithelial state, the microRNA partners dominate, and neither ZEB nor SNAIL is available in high levels.

"Usually, if you have two genes that are mutually limiting, you have only two possibilities," Ben-Jacob said. "In the first case, gene A is highly expressed and inhibits gene B. In the other, gene B is highly expressed and it inhibits A. This is true in the case of ZEB and miR200. One of these is 'on' and the other is 'off,' so it's clear that this is the decision element in the switch."

SNAIL and miR34 interact more weakly. As a result, both can be present at the same time, with the amount of each varying based upon inputs from a number of other proteins, including several other cancer genes.

"One of the most important things the model showed us was how SNAIL and miR34 act as an integrator," Ben-Jacob said. "This part of the circuit is acted on by multiple cues, and it integrates those signals and feeds information into the decision element. It does this based upon the level of SNAIL, which activates ZEB and inhibits miR200."

In modeling the ZEB/miR200 decision circuit, the team found that it operates as a "ternary" or three-way, switch. The rea
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Physicists explore properties of electrons in revolutionary material
2. Biophysicists unravel secrets of genetic switch
3. Powerful sequencing technology decodes DNA folding pattern
4. Deadly E. coli strain decoded
5. Mysterious snake disease decoded
6. Researchers decode birch tree genome sequence for the first time
7. Genome decoded: Scientists find clues to more disease-resistant watermelons
8. RIT scientists decode 3 bacterial strains common to grapevines and sugarcane
9. Global research team decodes genome sequence of 90 chickpea lines
10. Scientists decode genome of painted turtle, revealing clues to extraordinary adaptations
11. OHSU teams with Intel to decode the root causes of cancer and other complex diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Physicists decode decision circuit of cancer metastasis
(Date:5/14/2015)... May 14, 2015 Research and Markets ... "Fingerprint Sensors Market in Smart Mobile Devices " ... believes that 2014 was a watershed year for fingerprint ... of ,Apple Pay,. Apple gave fingerprint sensors a raison ... service. Fingerprint sensors are a must-have feature in flagship ...
(Date:5/11/2015)... 2015  Through a well-rounded UAS delegation representing private industry, ... strong showing at AUVSI,s Unmanned 2015 conference last week in ... Ohio,s UAS industry met with over 200 hundred ... along the UAS ecosystem. "Our message is ... for Aerospace Rich Knoll . "If you want to ...
(Date:5/8/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ), the ... of the executive management team will present at the following ... and Telecom Conference Date: May 18, 2015 Time: ... MA Cowen and Company Technology, Media ... Location: The New York Palace Hotel, New York, ...
Breaking Biology News(10 mins):Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2Synaptics to Present at Upcoming Investor Conferences 2
... Nitrogen is both an essential nutrient and a ... fertilizer that feeds billions, a benefit and a hazard, ... transportation have spread nitrogen liberally around the planet, say ... Issues in Ecology series, "Excess Nitrogen in the ...
... of the sex of a fetus until after 30 weeks ... some ethnic groups in Canada and the United States, states ... Journal ). Female feticide that is, choosing to ... is an issue in several Asian countries including India, China, ...
... BOSTON, MA -- From tracking activities within ... up human hair, several experiments have already demonstrated ... called multi-isotope imaging mass spectometry, or MIMS, developed ... MIMS can produce high-resolution, quantitative three-dimensional images of ...
Cached Biology News:Solutions for a nitrogen-soaked world 2Female feticide in Canada requires action 2Quantitative imaging application to gut and ear cells are reported in 2 Nature papers 2
(Date:5/25/2015)... (PRWEB) May 26, 2015 Where is ... Jack Uldrich says, "The honest answer is that nobody ... four keynote speeches throughout the month of June, starting ... topics vary from future-proofing to top tech trends. And ... research is where the universe is expanding to. According ...
(Date:5/22/2015)... May 22, 2015 Charm Sciences, ... Department of Agriculture (USDA), Grain Inspection, Packers and ... contract to Charm Sciences to monitor aflatoxin in ... (water-based) and ROSA FAST Aflatoxin Quantitative Test (solvent-based). ... Test uses Water Extraction Technology to extract ...
(Date:5/21/2015)... Specialty Pharmacy Times has completed ... to BPA Worldwide as a business publication member. ... data for Specialty Pharmacy Times based on business/distribution, ... a member of BPA Worldwide, Specialty Pharmacy Times ... with the most reliable, unequaled data,” said Chris ...
(Date:5/21/2015)... Imagine being able to probe and truly ... Being able to read faces and enjoy genuine invisible ... their thoughts and actions like never before. Use ... unique abstract paintings and video, or, play a completely ... as it creates action, dialog, and outcomes based on ...
Breaking Biology Technology:Futurist Jack Uldrich Says Embracing Our Ignorance is the Key to Unlearning 2Futurist Jack Uldrich Says Embracing Our Ignorance is the Key to Unlearning 3USDA-GIPSA (FGIS) Awards 5 Year Contract for Aflatoxin Tests to Charm Sciences 2Specialty Pharmacy Times Joins BPA Worldwide 25 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2
... Biotech Group (USA) Reports Second Quarter and Six-Month Results -- NEW YORK, Aug. 19 /PRNewswire-Asia/ -- ... ... lpUnit=,PRN,; --> ... var s = ,; var first_result; // Results are keyed by longUrl, so we need to ...
... Silence Therapeutics plc (AIM: SLN), a leading international ... partner, Quark Pharmaceuticals, Inc. ("Quark"), has announced the grant ... worldwide license to develop and commercialise QPI-1002, a p53 ... Quark is currently conducting a Phase II ...
... WOODLANDS, Texas, Aug. 19 US Oncology, Inc., ... that in less than two decades it has played ... therapies approved by the US Food and Drug Administration ... (Logo:   http://www.newscom.com/cgi-bin/prnh/20100517/DA06089LOGO ) Tasigna ...
Cached Biology Technology:Tiens Biotech Group (USA) Reports Second Quarter and Six-Month Results 2Tiens Biotech Group (USA) Reports Second Quarter and Six-Month Results 3Tiens Biotech Group (USA) Reports Second Quarter and Six-Month Results 4Tiens Biotech Group (USA) Reports Second Quarter and Six-Month Results 5Tiens Biotech Group (USA) Reports Second Quarter and Six-Month Results 6Tiens Biotech Group (USA) Reports Second Quarter and Six-Month Results 7Tiens Biotech Group (USA) Reports Second Quarter and Six-Month Results 8Tiens Biotech Group (USA) Reports Second Quarter and Six-Month Results 9Tiens Biotech Group (USA) Reports Second Quarter and Six-Month Results 10Tiens Biotech Group (USA) Reports Second Quarter and Six-Month Results 11Tiens Biotech Group (USA) Reports Second Quarter and Six-Month Results 12Silence Therapeutics' Partner Quark Signs Exclusive Option Agreement With Novartis for Development and Commercialisation of QPI-1002 2US Oncology Helps Deliver Latest Cancer Therapies Through Local Community Access to Cutting Edge Research 2US Oncology Helps Deliver Latest Cancer Therapies Through Local Community Access to Cutting Edge Research 3US Oncology Helps Deliver Latest Cancer Therapies Through Local Community Access to Cutting Edge Research 4