Navigation Links
Physicians awarded $4 million to study effects of fertility treatments and obstetric care
Date:12/17/2013

LOS ANGELES ( Dec.18, 2013) Two Cedars-Sinai physician-researchers have been awarded grants totaling $4 million from the National Institutes of Health to study how the environment both in the womb and in the hospital where the baby is born can affect the newborn and the mother.

Pregnancies resulting from fertility treatments are at increased risk for complications, including low birth weight, birth defects and infant mortality. Approximately 2 percent of babies born in the United States are conceived using assisted reproductive technologies.

Margareta D. Pisarska, MD, director of the Fertility and Reproductive Medicine Center and director of the Division of Reproductive Endocrinology and Infertility in the Department of Obstetrics and Gynecology at Cedars-Sinai, is the lead investigator of the study examining the causes of pregnancy complications couples can face when they get help to conceive. The study, sponsored by the National Institute of Child Health and Human Development, is believed to be the first ever to examine the causes of problems in pregnancies resulting from fertility treatments.

"We are trying to understand what is causing the increased risk of problems for pregnancies achieved by in vitro fertilization," said Pisarska. "It is the first study of its kind in humans and it is unique because we will be able to look at the earliest point in human pregnancy, when the fertilized egg implants, to determine if the adverse outcomes are the result of the genetic make-up of the parents that led to problems conceiving in the first place, or whether it is the result of the infertility treatments themselves."

The study, titled "Adverse Outcomes of Assisted Reproductive Technologies: Genetics or Epigenetics," is funded by a $3.37 million grant from the NIH and is expected to take five years to complete. During the study, researchers also will be looking into the fetal origins of adult diseases to gain insight into how normal pregnancies develop in the womb. "We hope to determine how environmental changes during our development in utero will influence long-term health risks such as heart disease and diabetes, even through adulthood," said Pisarska.

The second study, funded by the Agency for Health Care Research and Quality, will examine the effect a hospital's environment has on childbirth. Kimberly D. Gregory, MD, MPH, vice chair of Women's Healthcare Quality and Performance Improvement in the Department of Obstetrics and Gynecology at Cedars-Sinai, will investigate the role obstetrical resources and available levels of care play in labor and delivery.

"Maternal morbidity and mortality continue to be a problem in California and nationally, and it is estimated that 40 percent of maternal deaths are preventable," said Gregory, who has served on numerous state and federal health policy committees. To address the problem, healthcare policymakers are considering the creation of obstetrical levels of care at hospitals, much like what is in place for newborns.

"For the past 40 years, hospitals have standardized the care of newborns into 'levels,' with Level I offering basic neonatal care to child and mother, up to Level III or Level IV neonatal intensive care units, or NICUs, for newborns recovering from serious illness or who were born extremely premature," Gregory said. "Our study seeks to identify what would constitute a Level I, or low-risk obstetrical unit, and what would be required for a Level IV designation for high-risk pregnancies.

"The challenge for hospitals is that a low-risk woman can become high-risk without many signs or symptoms," Gregory added. "There is a need to have the right clinical policies and procedures in place to handle a suddenly complicated pregnancy, and that is what this research will identify."

Pisarska's study is supported by NIH R01 grant HD074368 and Gregory's research is supported by NIH R01 grant HS017713.


'/>"/>

Contact: Laura Coverson
laura.coverson@cshs.org
310-423-5215
Cedars-Sinai Medical Center
Source:Eurekalert

Related biology news :

1. Uganda Heart Institute physicians and nurses visit Texas Childrens Heart Center
2. Children with diplegic and hemiplegic cerebral palsy: Who can be paid more attention by rehabilitation physicians?
3. Study finds physicians need to better recognize use of herbal supplements while breastfeeding
4. Survey of physicians suggests tablets more useful than smartphones
5. Georgia Physicians Study Published in The Journal of Urology
6. Physicians belief about obesity causes impacts advice and care
7. Scripps physicians call for change in cancer tissue handling
8. Physicians admit feeling under qualified and lacking necessary education to treat obesity
9. Young gamers offer insight to teaching new physicians robotic surgery
10. FirstMark Exhibiting and Presenting at the San Diego Academy of Family Physicians 55th Annual Postgraduate Symposium
11. UT Dallas awarded $1 million to improve prosthetics for soldiers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... , March 21, 2017 Optimove ... used by retailers such as 1-800-Flowers and AdoreMe, ... — Product Recommendations and Replenishment. Using Optimove,s machine learning ... personalized product and replenishment recommendations to their customers ... on predictions of customer intent drawn from a ...
(Date:3/13/2017)... -- Future of security: Biometric Face Matching software  ... ... Face Matching enables to match face pictures against each other or against large ... Identification Systems) ... is the fastest software for biometric Face Matching on the market. The speed ...
(Date:3/6/2017)... MATEO, Calif. , March 6, 2017 /PRNewswire/ ... marketing and sales technology, today announced Predictive Sales ... solution for infusing actionable sales intelligence into Salesforce. ... to automatically enable their sales organizations with deep ... messages that allow for intelligent engagement. Predictive Sales ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... ... March 28, 2017 , ... ... release of LabKey’s newest software solution, LabKey Biologics . Built in collaboration ... and biotech organizations, LabKey Biologics provides drug research teams tools for biological entity ...
(Date:3/28/2017)... 28, 2017 Focus is ... sector due to the scientifically intensive operations of ... agricultural, environmental, and industrial. In today,s pre-market research, Stock-Callers.com ... Inc. (NASDAQ: PTLA), OvaScience Inc. (NASDAQ: OVAS), Ocera ... (NASDAQ: OCUL ). Learn more about ...
(Date:3/28/2017)... 28, 2017 /PRNewswire/ -RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSXV: ... compelling safety and clinical data from its phase 1/2 tendon ... hair follicle-derived fibroblasts (RCT-01) as a treatment for Achilles tendinosis. ... ... safety profile at 6 months and showed no serious adverse ...
(Date:3/28/2017)... ... March 28, 2017 , ... Executive search firm, ... Avomeen Analytical Services. Harvill is a distinguished life sciences expert with a proven ... a leader in a wide range of services related to laboratory testing and ...
Breaking Biology Technology: