Navigation Links
Physical reason for chromosome shape discovered
Date:1/14/2014

This work gives a solution to a fundamental question in structural biology: Why do metaphase chromosomes have their characteristic elongated cylindrical shape? The proposed solution is consistent with the structure of metaphase chromatin and with the nanomechanical properties of chromatin and chromosomes. It is a research at the interface between biology (higher order chromatin structure) and physical sciences (supramolecular structures and nanomaterials). This approach goes beyond the capabilities of current structural biology based on X-ray crystallography, because it allows the study of an enormous supramolecular assembly that cannot be crystallized. The work has been published in the Journal of the Royal Society Interface.

In the cell nucleus, genomic DNA molecules are associated with histone proteins and form long chromatin filaments containing many nucleosomes. Previous microscopy studies performed by researchers at the Chromatin Laboratory directed by professor Joan-Ramon Daban (Biosciences Unit of the Department of Biochemistry and Molecular Biology, UAB) showed that, during cell division, chromatin filaments are folded into multilayer planar structures. This discovery led to the thin-plate model in which it was proposed that condensed chromosomes are formed by many stacked layers of chromatin oriented perpendicular to the chromosome axis.

The measurements performed by professor Daban show that chromosomes of different animal and plant species exhibit great differences in size (which are dependent on the amount of DNA that they contain), but in all cases chromosomes are elongated cylinders that have relatively similar shape proportions (the length to diameter ratio is approximately 13). This study demonstrates that it is possible to explain this morphology by considering that chromosomes are self-organizing supramolecular structures formed by stacked layers of planar chromatin having different nucleosome-nucleosome interactio
'/>"/>

Contact: Joan-Ramon Daban
Joanramon.daban@uab.cat
34-935-811-616
Universitat Autonoma de Barcelona
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Increasing clarity for medics in suspected physical abuse cases
2. NIH-funded study examines use of mobile technology to improve diet and physical activity behavior
3. UTHealth study addresses barriers to physical activity counseling
4. Harvards Wyss Institute to develop smart suit that improves soldiers physical endurance
5. Iron, vitamins could affect physical fitness in adolescents
6. Childrens physical activity levels are not enough to counteract sedentary lifestyles
7. Biophysical Society names 5 2013 award recipients
8. Biophysical Society names 2013 Distinguished Service, Emily M. Gray, and Founders awardees
9. New study finds milk-drinking kids reap physical benefits later in life
10. Dark Energy: Life beneath the seafloor discussed at upcoming American Geophysical Union conference
11. UT study: Students who are more physically fit perform better academically
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Physical reason for chromosome shape discovered
(Date:9/30/2014)... Sept. 30, 2014  Spectra Automation, a ... the biotech and power generation industries, announced ... Bioprocess Manager, an easy-to-use and cost-effective data ... bioprocess development laboratories. Most ... and analyzer systems. Accessing and consolidating data ...
(Date:9/29/2014)... study confirms that the exposure to tar tended to ... regular cigarettes. Similarly, exposure to nicotine tended to ... type of cigarette in several countries around the world. ... toxic chemicals in the smoke of these cigarettes are ... levels of chemicals in the smoke are not necessarily ...
(Date:9/29/2014)... Parents with children at home should use ventilation when ... University are recommending, after a new study showed an ... symptoms and chronic bronchitis. , "In homes where a ... asthma and wheezing is higher than in homes where ... Smit, an associate professor in the College of Public ...
Breaking Biology News(10 mins):Spectra Automation Introduces RECONN Bioprocess Manager 2Slim cigarette smokers not exposed to more harmful chemicals 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3
... Before he left for Bangladesh to conduct a workshop ... California, Riverside did not quite know what to expect. ... workshop, called "Workshop on Genomics and Proteomics," from July 16 ... public university in Bangladesh. What his brief visit to ...
... , The winners of the 2012 Science in Society ... Writers, are: In the Book category, Seth ... of Medicine, Science, and Fear (Simon & Schuster) ... from the Center for Public Integrity (Jim Morris, Chris ...
... The same type of microwave oven technology that most people ... application in the solar energy industry, providing a new way ... environmental concerns. Engineers at Oregon State University have for ... in the synthesis of copper zinc tin sulfide, a promising ...
Cached Biology News:Lessons from Bangladesh 2Lessons from Bangladesh 32012 Science in Society Journalism Awards announced 22012 Science in Society Journalism Awards announced 3Microwave ovens may help produce lower cost solar energy technology 2
(Date:9/30/2014)... Shimadzu Scientific Instruments has released ... highly precise tool for measuring displacement in rubber ... 1000-mm maximum movement distance, the DSES-1000 can measure ... length of 10 mm. In addition, it achieves ... stroke and within +/- 100 µm below 50-mm ...
(Date:9/30/2014)... Over the last decade, the laboratory ... R&D budgets and increased acceptance of new filtration technologies ... biotechnology industries are also catalyzing the growth of laboratory ... expected to grow at a strong CAGR during the ... worth $2,532.6 million by 2019. The market is mainly ...
(Date:9/30/2014)... San Jose, California (PRWEB) September 30, 2014 ... generally measure the level of each type of cholesterol ... essential since the presence of excessive cholesterol levels in ... is a precursor condition to heart attack and other ... of fatality worldwide, therefore testing for cholesterol levels on ...
(Date:9/30/2014)... 2014 CORD:USE Cord Blood Bank – ... has entered into an Equity and Exclusive Services Agreement ... series of patented technologies for the isolation of human ... Tianhe is performing Phase I/II clinical trials in ... using Tianhe,s Stem Cell Educator Therapy showing that ...
Breaking Biology Technology:Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4
... ZUTPHEN, Netherlands , June 4, 2010 ... private cordblood,banking. The four scientists supported the "Family Cord Blood Bank" which ... , , ... largest stem cell bank in Europe , is,very pleased with this ...
... , June 3 Lexicon Pharmaceuticals, Inc. ... developing breakthrough treatments for human disease, announced today that Alan ... will present at two investor conferences next week in New ... Healthcare Conference on Wednesday, June 9, 2010 10 ...
... The U.S. Patent Office issued Patent No. 7,711,580, A System and Method ... . , , , ... and method for matching patients with clinical trials and particular trial sites, prequalifying ... allow them to inform themselves about available clinical trials and trial sites. , ...
Cached Biology Technology:Scientists Give the Go-Ahead for Private Storage of Stem Cells From Umbilical Cord Blood 2Scientists Give the Go-Ahead for Private Storage of Stem Cells From Umbilical Cord Blood 3Lexicon to Present at Two Major Healthcare Investor Conferences 2Lexicon to Present at Two Major Healthcare Investor Conferences 3EmergingMed Granted Patent 2EmergingMed Granted Patent 3
Rabbit polyclonal to MDM2 (phospho S185) ( Abpromise for all tested applications). entrezGeneID: 4193 SwissProtID: Q00987...
ASCIZ...
...
Yields DNA greater than 50 kb in length from yeast, fungi, Gram neg. and Gram pos. bacteria...
Biology Products: