Navigation Links
Physical reason for chromosome shape discovered
Date:1/14/2014

This work gives a solution to a fundamental question in structural biology: Why do metaphase chromosomes have their characteristic elongated cylindrical shape? The proposed solution is consistent with the structure of metaphase chromatin and with the nanomechanical properties of chromatin and chromosomes. It is a research at the interface between biology (higher order chromatin structure) and physical sciences (supramolecular structures and nanomaterials). This approach goes beyond the capabilities of current structural biology based on X-ray crystallography, because it allows the study of an enormous supramolecular assembly that cannot be crystallized. The work has been published in the Journal of the Royal Society Interface.

In the cell nucleus, genomic DNA molecules are associated with histone proteins and form long chromatin filaments containing many nucleosomes. Previous microscopy studies performed by researchers at the Chromatin Laboratory directed by professor Joan-Ramon Daban (Biosciences Unit of the Department of Biochemistry and Molecular Biology, UAB) showed that, during cell division, chromatin filaments are folded into multilayer planar structures. This discovery led to the thin-plate model in which it was proposed that condensed chromosomes are formed by many stacked layers of chromatin oriented perpendicular to the chromosome axis.

The measurements performed by professor Daban show that chromosomes of different animal and plant species exhibit great differences in size (which are dependent on the amount of DNA that they contain), but in all cases chromosomes are elongated cylinders that have relatively similar shape proportions (the length to diameter ratio is approximately 13). This study demonstrates that it is possible to explain this morphology by considering that chromosomes are self-organizing supramolecular structures formed by stacked layers of planar chromatin having different nucleosome-nucleosome interactio
'/>"/>

Contact: Joan-Ramon Daban
Joanramon.daban@uab.cat
34-935-811-616
Universitat Autonoma de Barcelona
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Increasing clarity for medics in suspected physical abuse cases
2. NIH-funded study examines use of mobile technology to improve diet and physical activity behavior
3. UTHealth study addresses barriers to physical activity counseling
4. Harvards Wyss Institute to develop smart suit that improves soldiers physical endurance
5. Iron, vitamins could affect physical fitness in adolescents
6. Childrens physical activity levels are not enough to counteract sedentary lifestyles
7. Biophysical Society names 5 2013 award recipients
8. Biophysical Society names 2013 Distinguished Service, Emily M. Gray, and Founders awardees
9. New study finds milk-drinking kids reap physical benefits later in life
10. Dark Energy: Life beneath the seafloor discussed at upcoming American Geophysical Union conference
11. UT study: Students who are more physically fit perform better academically
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Physical reason for chromosome shape discovered
(Date:1/22/2015)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication ... success of the Wocket™ smart wallet at CES 2015 in ... as one of the "11 Hot Products at CES" in a review ... So Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" ...
(Date:1/22/2015)... 22, 2015 Research and Markets ( ... "Global Wearable Technologies Market and Applications, Opportunities, ... and Forecast 2014-2020" report to their offering. ... devices that can be worn on the user,s ...
(Date:12/22/2014)... (NASDAQ: NXTD and NXTDW) ("NXT-ID" or the ... commerce market, announces it has retained famous pickpocket, entertainer and ... CES debut of the Wocket™ biometric smart wallet.  ... booth January 6th and 7 th , 2015, demonstrating some ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
... Insect Technique (SIT), the release of sexually sterile male insects ... to the problem of malaria in Africa. A new supplement, ... reviews the history of the technique, and features details about ... The supplement, edited by Dr Mark Benedict, who along with ...
... Researchers from the universities of Bristol and St. Andrews in ... skin affects how healthy and therefore attractive they appear, and ... most desirable complexion. The work will be published in the ... Using specialist computer software, a total of 54 ...
... , , SANTA ANA, ... ( SCMM, Prime Standard: SMY), a leading provider of solutions ... results for its third quarter ended September 30, 2009. In ... Corporation, revenue more than doubled, reflecting the success of the ...
Cached Biology News:Are sterile mosquitoes the answer to malaria elimination? 2Skin color gives clues to health 2SCM Microsystems Reports Third Quarter 2009 Results 2SCM Microsystems Reports Third Quarter 2009 Results 3SCM Microsystems Reports Third Quarter 2009 Results 4SCM Microsystems Reports Third Quarter 2009 Results 5SCM Microsystems Reports Third Quarter 2009 Results 6SCM Microsystems Reports Third Quarter 2009 Results 7SCM Microsystems Reports Third Quarter 2009 Results 8SCM Microsystems Reports Third Quarter 2009 Results 9SCM Microsystems Reports Third Quarter 2009 Results 10SCM Microsystems Reports Third Quarter 2009 Results 11SCM Microsystems Reports Third Quarter 2009 Results 12
(Date:1/22/2015)... 2015 Dr. Greg Leyer of UAS Labs ... Natural Supplements Pre-Conference seminar on probiotics in San Diego, CA. ... continuing education conference for health care professionals. This year’s pre-conference ... of probiotics in health. Dr. Leyer spoke about the emerging ...
(Date:1/22/2015)... SAN DIEGO , Jan. 22, 2015   ... company, and Sequenom, Inc. (NASDAQ: SQNM ... a development agreement for next generation noninvasive prenatal ... Cypher,s genome interpretation technology, called Mantis™, to advance ...
(Date:12/24/2014)... Md. , Dec. 24, 2014  United Therapeutics Corporation ... Inc. (NYSE: MDT ) has submitted a ... Administration (FDA) for the use of Medtronic,s SynchroMed ® ... developed catheter) for use with United Therapeutics, Remodulin ® ...
(Date:12/24/2014)... December 23, 2014 GMO corn cases filed ... are in the process of being consolidated in a Kansas ... Re: Syngenta AG MIR 162 Corn Litigation, MDL No. 2591 ... , Management of the Syngenta GMO corn multidistrict litigation (MDL) ...
Breaking Biology Technology:Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2
... , , NEW YORK, Dec. 15 ... is available in its catalogue: , The ... 2015, Pipeline Analysis and Reimbursement , ... , The author has released its latest research "The ...
... , WILMINGTON, Del. and CHARLOTTESVILLE, Va., ... and the University of Virginia (UVa) in Charlottesville, today ... collaboration to enhance development of new treatments primarily for ... peripheral vascular disease (PAD). , (Logo: http://www.newscom.com/cgi-bin/prnh/20091027/PH99766LOGO ...
... 15 The Mosaic Company (NYSE: MOS ) plans to ... tables on Tuesday, January 5, 2010, after the close of trading ... on Mosaic,s website at mosaicco.com/investors. , The Company will ... 2010, to discuss the results. The call will begin at ...
Cached Biology Technology:Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 2Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 3Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 4Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 5Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 6Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 7Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 8Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 9Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 10Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 11Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 12Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 13Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 14Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 15Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 16Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 17Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement 18AstraZeneca and the University of Virginia Sign Strategic Research Collaboration to Develop Novel Treatments for Cardiovascular Disease 2AstraZeneca and the University of Virginia Sign Strategic Research Collaboration to Develop Novel Treatments for Cardiovascular Disease 3Mosaic Announces Second Quarter Fiscal Year 2010 Earnings Release and Conference Call 2