Navigation Links
Photopharmacology: Optoswitches turn pain off and sight on
Date:2/26/2014

for various types of visual impairment and certain forms of congenital blindness. In collaboration with researchers at the University of California in Berkeley, Trauner and his group have, for the first time, succeeded in restoring visual function to mice in which retinal photoreceptive cells had degenerated. The trick was to use a new synthetic switch to confer light sensitivity on the retinal ganglion cells in these mice, which normally respond to signals from the rods and cones upstream of them.

"We demonstrated some time ago that a molecule called AAQ is capable of causing nerve cells to become light-sensitive, because it modifies the behavior of ion channels in their surface membranes," Trauner says. In the meantime, he and his group had synthesized an improved variant of the AAQ switch, which they call DENAQ. The scientists in Berkeley have now shown that DENAQ can indeed restore light responsiveness to a retina that has lost its primary photoreceptive cells, as they report in the latest issue of the journal Neuron. "From the clinical point of view, DENAQ is a great advance on AAQ, because it acts specifically on a particular type of ion channel that is essential for the transmission of signals received from the rods and cones," says Trauner. In addition, and unlike AAQ, it reacts to wavelengths present in normal daylight, to which the retina is normally sensitive. "In the future, this approach could help to restore sight in people suffering from certain forms of blindness."

"In principle, one can imagine a whole range of possible applications for photopharmacology," says Trauner. "Some GPCRs, for instance, are targeted by neurotransmitters, and their functions are compromised in diseases of the central nervous system, so it is possible that optical switches could also be of interest in the treatment of conditions such as depression or epilepsy. And beyond that, one could make use of the unparalleled spatial and temporal precision of light s
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-6938
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. New insights into cloud formation
2. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
3. Hiding in plain sight, a new frog species with a weird croak is identified in New York City
4. Hiding in plain sight, new frog species found in New York City
5. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
6. Discovery offers insight into treating viral stomach flu
7. Fine-scale analysis of the human brain yields insight into its distinctive composition
8. Chimpanzee ground nests offer new insight into our ancestors descent from the trees
9. Battle of the sexes offers evolutionary insights
10. Analysis of speed of Greenland glaciers gives new insight for rising sea level
11. Mice with big brains provide insight into brain regeneration and developmental disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/14/2015)... NEW YORK , May 14, 2015 ... specializing in identity verification and online remote ... Instructure, a software-as-a-service (SaaS) company and creator ... Shared customers of the two companies will ... Proctortrack in Canvas. As a ...
(Date:5/11/2015)... , May 11, 2015 Curemark LLC, a ... start of a new Phase III double blind, randomized, ... novel formulation, CM-AT, on all children ages 3-8 with ... FDA Phase III double blinded clinical trial for CM-AT ... levels of the digestive enzyme chymotrypsin. This new trial ...
(Date:5/7/2015)... Sweden , May 7, 2015 ... touch fingerprint sensors, FPC1022 and FPC1035, FPC,s smallest ... and FPC1035 are mainly considered for integration on ... size gives smartphone OEMs increased possibilities to integrate ... The decreased size also improves possibilities for module ...
Breaking Biology News(10 mins):Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2
... 2011 Metabolism encompasses the biochemical reactions that sustain ... systems: one that breaks down nutrients to generate energy ... building blocks cells need to thrive. Considering the fundamental ... metabolic dysfunctions can lead to serious diseases. ...
... progressively harder to navigate the maze of Los Angeles freeways. ... vehicle pollution, mice showed significant brain damage including signs ... toxin is not an exhaust gas, but a mix of ... car parts and pavement, according to the study to be ...
... Frequent reports of accelerating species losses invariably raise ... should work to conserve biodiversity. Biologists have traditionally ... are often presumed to be offered by biodiversity--benefits like ... and helping to purify air and water, among many ...
Cached Biology News:At EB2011: The role of metabolism in disease 2Freeway air bad for mouse brain 2Precedent-setting evidence of the benefits of biodiversity 2Precedent-setting evidence of the benefits of biodiversity 3Precedent-setting evidence of the benefits of biodiversity 4
(Date:6/2/2015)... San Diego, Calif. (PRWEB) June 02, 2015 ... developer of build-to-order, independent blade-based and rackmount computing ... centers, today announced the launch of its high ... offering, the Cirrascale Slipstreamâ„¢ RM1622D . The ... Xeon® processor E3-1200 v4 product family with Intel® ...
(Date:6/2/2015)... , June 2, 2015   Intrexon ... in synthetic biology, announced today the appointment of ... Vice President, Consumer Sector.  Mr. Jarry will lead ... in products and applications for consumer markets.  ... 30 years of experience in leading global life ...
(Date:6/2/2015)... Ohio , June 2, 2015 GOJO, ... pledged its commitment to antibiotic stewardship at the White ... human and animal health organizations and stakeholders at the ... five years to slow the emergence of antibiotic-resistant bacteria, ... antibiotics, and prevent the spread of resistant infections. ...
(Date:6/1/2015)... 02, 2015 Chosen for his ... Jack Uldrich has been selected as keynote speaker ... today. He will deliver his keynote: "Don't Stop ... delivered presentations to the American Medical Association, Blue ... Neurology, Alcetel-Lucent/Verizon Forum on Wireless Healthcare, United Healthcare, ...
Breaking Biology Technology:Cirrascale® Announces Support for Intel® Xeon® Processor E3-1200 v4 Product Family; Launches Server Offering Optimized for Low Cost-per-Stream Transcoding Applications 2Cirrascale® Announces Support for Intel® Xeon® Processor E3-1200 v4 Product Family; Launches Server Offering Optimized for Low Cost-per-Stream Transcoding Applications 3Intrexon Announces New Sector Leader 2Intrexon Announces New Sector Leader 3GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 2GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 3GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 4Futurist Jack Uldrich to Address the Future of Pharmaceuticals 2
... Plant Biotechnology Industry, WILMINGTON, Del., Oct. 18 ... the best employers in the biotechnology and,pharmaceutical industry in ... is the first DuPont appearance on the survey,s top ... of other companies in the,plant biotechnology industry. DuPont also ...
... (Nasdaq: NPSP ) announced today the expiration and,final ... all of its outstanding,3.0% Convertible Notes due 2008. The ... October 17, 2007. As of the expiration date ... notes, representing approximately 99.7% of the notes,outstanding, had been ...
... Completes Enrollment in First Cohort --, SAN ... (TSX:NVN) today announced that the Company,has completed enrollment ... clinical trial,to assess the safety and tolerability of ... The trial is expected to dose up ...
Cached Biology Technology:DuPont Named Among Top Biotechnology Employers by Science Magazine 2NPS Pharmaceuticals Announces Results of Tender Offer 2NPS Pharmaceuticals Announces Results of Tender Offer 3Nventa updates progress of cervical dysplasia trial with new HspE7 2Nventa updates progress of cervical dysplasia trial with new HspE7 3Nventa updates progress of cervical dysplasia trial with new HspE7 4Nventa updates progress of cervical dysplasia trial with new HspE7 5
Request Info...
... The Light Diagnostics Cytomegalovirus (CMV) pp65 Antigenemia ... qualitative identification of lower matrix protein pp65 ... Kit Components: ... One bottle containing 220 mL of buffered ...
CHIMAERIC HUMAN IgA2 ANTI NP...
... suspension (non-adherent) cells, RNA ture ... or centrifugation to separate cells ... with 96-well GenePlate®. RiboCap™ plates ... sizes and contain the appropriate ...
Biology Products: