Navigation Links
Photopharmacology: Optoswitches turn pain off and sight on
Date:2/26/2014

Photoreactive compounds developed by scientists of Ludwig-Maximilians-Universitaet (LMU) in Munich directly modulate nerve-cell function, and open new routes to the treatment of neurological diseases, including chronic pain and certain types of visual impairment.

All modes of sensory perception are based on communication between nerve cells. Both the response to the primary stimulus and the transmission of the resulting signal depend on the function of specialized receptor proteins that are associated with the surface membranes of neurons. Many sensory neurons respond only to a single sensory modality, such as mechanical stimulation or temperature. However, Dirk Trauner, Professor of Chemical Biology and Genetics at LMU, has helped develop a method which, in principle, enables all types of neuroreceptors to be controlled by light. "This is achieved by using synthetic molecular compounds that react specifically to light as switches for natural receptors," he says. "The combination results in hybrid photoreceptors, which effectively make the nerve cells that bear them responsive to light. In the long term, we hope to use this approach as the basis for new therapies for neurological disease." Two new studies, on pain receptors and a mouse model for congenital blindness, now report significant advances toward the realization of this goal.

Synthetic opioid as a painkiller

So-called opioids, natural substances related to morphine, have been used as painkillers for thousands of years. The body also synthesizes endogenous opioids, known as endorphins, which bind to the same receptors and have the same analgesic effects as morphine. By chemically modifying the synthetic opioid fentanyl, which is used clinically both as an anesthetic and as an extremely potent painkiller, Trauner and his team have succeeded in conferring photosensitivity on a particular class of opioid receptor. The modified fentanyl retains the ability to bind
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-6938
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. New insights into cloud formation
2. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
3. Hiding in plain sight, a new frog species with a weird croak is identified in New York City
4. Hiding in plain sight, new frog species found in New York City
5. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
6. Discovery offers insight into treating viral stomach flu
7. Fine-scale analysis of the human brain yields insight into its distinctive composition
8. Chimpanzee ground nests offer new insight into our ancestors descent from the trees
9. Battle of the sexes offers evolutionary insights
10. Analysis of speed of Greenland glaciers gives new insight for rising sea level
11. Mice with big brains provide insight into brain regeneration and developmental disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... drugs already approved by the U.S. Food and Drug ... growth of certain bacterial pathogens inside human cells, including ... fever. The findings, published in mBio , the ... demonstrate a new way of identifying non-antibiotic drugs that ... A handful of drugs on the list inhibit the ...
(Date:7/28/2014)... Amundsen reached the South Pole in 1911, but new ... any human. , Using data from 16 ice cores ... including the South Pole, a group led by Joe ... Nevada, created the most accurate and precise reconstruction to ... new record, described in an article published today in ...
(Date:7/28/2014)... States have a circulatory problem of the legs called ... even require surgery in serious cases. This disease can ... limb amputation. , At The University of Texas Health ... a non-surgical preventative treatment in a mouse model of ... circulation. Their proof-of-concept study appears in the journal ...
Breaking Biology News(10 mins):New route to identify drugs that can fight bacterial infections 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2
... from reducing cholesterol and having anticancerogenic properties, is characterised ... which genes are responsible for this activity ?the reason ... agent, was the aim of the PhD thesis by ... University of Navarre with the title, Molecular Characterisation of ...
... National Institutes of Health (NIH) announced today a new ... articles resulting from NIH-funded research. The policy ?the first ... release to the public manuscripts from research supported by ... of final publication. , These peer-reviewed, NIH-funded research publications ...
... harmless on human skin, but it is the ... indwelling medical devices. S. epidermidis is associated with ... prosthetic joints, replacement heart valves, and intravenous catheters, ... Moreover, the mechanism through which the organism becomes ...
Cached Biology News:Advances in the characterisation of the oyster mushroom genes 2NIH Calls on Scientists to Speed Public Release of Research Publications 2NIH Calls on Scientists to Speed Public Release of Research Publications 3
(Date:7/29/2014)... “PharmaSphere: Emerging Biotech Investment Report Strategic ... report provides in-depth analysis of the current trends ... capital segments of the financial industry, bearing in ... impact on the future of emerging biotechnology companies ... identifies regions of the world that are attracting ...
(Date:7/29/2014)... a particle be separated from its properties? On July ... the results of the first Cheshire Cat experiment, separating ... University in Orange, CA, and Vienna University of Technology. ... a grin," thought Alice in Wonderland, "but a grin ... ever saw in my life!" Alice,s surprise stems from ...
(Date:7/29/2014)... July 29, 2014 Second generation biofuels are ... by fossil fuels. However, as natural gas is very cheap, ... they are not as valuable as they could be in ... difficulty financing projects, has made it difficult for renewable energy ... get off the ground. For these reasons, certain companies have ...
(Date:7/29/2014)... SPRINGS, Colo. , July 29, 2014 /PRNewswire/ ... specializing in cannabis formulation-based drug development and related ... York Times for taking a strong position in ... its Sunday, July 27, 2014 publication.  The New ... editorials and articles this week exploring the issue ...
Breaking Biology Technology:Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 2Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 3Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 4The quantum Cheshire cat: Scientists separate a particle from its properties 2The quantum Cheshire cat: Scientists separate a particle from its properties 3The quantum Cheshire cat: Scientists separate a particle from its properties 4Renewable Waste Intelligence: Could Renewable Chemicals Be the Future for the Renewable Energy Industry? 2Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 2Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 3
...  Today, the Global Probiotics Council (GPC), a committee formed ... launch of the fifth annual Young Investigator Grant for ... in the amount of $50,000, to promising young researchers. ... the role of probiotics and gastrointestinal microbiota in health ...
... Arcion Therapeutics, a clinical stage biotechnology company developing ... received notice of allowance for a US Patent for ... ARC-2022 is being developed by Arcion for pain associated ... has been evaluated in a single-dose Phase 1 pharmacokinetic ...
... Jan. 4, 2012  Verify Brand™ announces the release ... 4.0 software. VB Enterprise 4.0 is a suite ... client and mobile software applications that enable comprehensive ... Trace® across the supply chain. VB Enterprise ...
Cached Biology Technology:Fifth Cycle of Probiotics & Microbiota Research Grant Announced 2Fifth Cycle of Probiotics & Microbiota Research Grant Announced 3Fifth Cycle of Probiotics & Microbiota Research Grant Announced 4Arcion Receives Notice of Allowance for US Patent for Novel Topical Lidocaine Formulation for Pain 2Verify Brand™ Announces the Release of VB Enterprise 4.0 2
Purified Mouse anti-Hu LAT (pY226) Storage Temperature: Refrigerate(2 to 8C)...
Tris-EDTA Buffer Solution, 1X, pH 8.0, sterile, Molecular Biology Grade...
... the most comprehensive, cost-effective solution to ... incorporated unprecedented quality into both our ... proven detection chemistries and antibodies that ... protocol. It also includes our competitively ...
...
Biology Products: