Navigation Links
Phasic firing of dopamine neurons is key to brain's prediction of rewards
Date:4/3/2009

San Antonio Researchers are one step closer to understanding the neurobiology that allows people to successfully learn motivated behaviors by associating environmental cues with rewarding outcomes, according to a study published yesterday in the Proceedings of the National Academy of Sciences' online Early Edition. Carlos Paladini, assistant professor of neuroscience at The University of Texas at San Antonio (UTSA) and UTSA graduate student Collin Lobb collaborated with researchers at The University of Washington at Seattle to study the firing patterns of midbrain dopamine neurons in mice during reward-based learning.

"Our research findings provide a direct functional link between the bursting activity of midbrain dopamine neurons and behavior. The research has significant applications for the improvement of health, because the dopamine neurons we are studying are the same neurons that become inactivated during Parkinson's Disease and with the consumption of psychostimulants such as cocaine and amphetamine," said Paladini, who is also a member of UTSA's Neurosciences Institute.

Midbrain dopamine neurons fire in two characteristic modes, tonic and phasic, which are thought to modulate distinct aspects of behavior. When an unexpected reward is presented to an individual, midbrain dopamine neurons fire high frequency bursts of electrical activity. Those bursts of activity allow us to learn to associate the reward with cues in our environment, which may predict similar rewards in the future.

The burst of electrical spikes observed in dopamine neurons is facilitated by a protein called the NMDA receptor, which is expressed on the surface of the dopamine cells. In this study, researchers removed the NMDA receptor from the dopamine cells only, leaving the dopamine neurons unable to fire bursts. The cells would otherwise fire normally.

When researchers placed the mice in reward-based situations, they found that the mice
'/>"/>

Contact: Christi Fish
christi.fish@utsa.edu
210-458-7584
University of Texas at San Antonio
Source:Eurekalert

Page: 1 2

Related biology news :

1. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
2. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
3. Unlocking mystery of why dopamine freezes Parkinsons patients
4. The birth and death of dopamine neurons: A new model for neurodegeneration
5. Basic guides to PCR, labeling neurons featured in Cold Spring Harbor Protocols
6. ORNL, St. Jude track neurons to predict and prevent disease
7. UCLA stem cells scientists make electrically active motor neurons from iPS cells
8. Researchers generate functional neurons from somatic cells
9. How mirror neurons allow us to learn and socialize by going through the motions in the head
10. Protecting neurons could halt Alzheimers, Parkinsons diseases
11. Mediator in communication between neurons and muscle cells found
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/28/2014)... juices are associated with a lower risk of developing ... of East Anglia (UEA). , Research published today ... flavanones (both subclasses of dietary flavonoids) significantly decrease their ... of cancer death among women. , The research ... between 25 and 55 for more than three decades. ...
(Date:10/27/2014)... German . ... via electrical signals, they communicate with each other at ... substances, the neurotransmitters, are stored in vesicles at the ... vesicles fuse with the cell membrane and release their ... synapses always have some readily releasable vesicles on standby. ...
(Date:10/27/2014)... breakthroughs may pave the way for vaccines and ... These flatworms, including tapeworms that cause hydatid diseases ... infect more than 300 million people and cause ... to chronic illness and death each year. , ... immunology, and tropical medicine, and scientific director of ...
Breaking Biology News(10 mins):Tea and citrus products could lower ovarian cancer risk, new UEA research finds 2Synapses always on the starting blocks 2Synapses always on the starting blocks 3GW researcher adapting breakthrough technologies to combat parasitic worm infections 2
... 14, 2012 Neuro Kinetics, Inc. (NKI) ( www.neuro-kinetics.com ... used worldwide for neurophysiologic/ neurotologic testing, said today that ... (NIH) Feedback Sessions in Washington D.C. on February 28, ... invitation only program funded by the NIH in cooperation ...
... why arteries stiffen in postmenopausal women have found a ... Kerrie Moreau, Ph.D., Associate Professor of Medicine at ... BH4 or tetrahydrobiopterin plays a key role in arterial ... of the enzyme endothelial nitric oxide synthase or eNOS. ...
... like difficulty hearing or remembering things can complicate everyday ... to date has focused on the disease,s less frequent ... number of patients have expressed their desire for a ... attacks its own central nervous system, which can cause ...
Cached Biology News:Neuro Kinetics Invited to Present at NIH Forum for Investors and Strategic Partners 2Critical element that improves vascular function in postmenopausal women found 2Wayne State University researcher's model will target causes of everyday MS symptoms 2Wayne State University researcher's model will target causes of everyday MS symptoms 3
(Date:10/27/2014)... October 27, 2014 The report ... Intelligent Traffic Management, Communication, Monitoring), and by Display ... to 2019” segments the global market into various ... It also identifies the drivers and restraints for ... challenges. , Browse 75 market tables and 37 ...
(Date:10/27/2014)... 2014 Janssen Biotech, Inc. and the ... today the launch of Get Your ... campaign designed to provide resources for people living ... role of nutrition and appropriate therapy in managing ... associated with this release, please click: http://www.multivu.com/players/English/7261131-janssen-ccfa-get-your-full-course-for-ibd-wellness-with-sunny-anderson/ ...
(Date:10/26/2014)... (PRWEB) October 26, 2014 The ... Routers, ADC, Network Security Equipment, WAN Optimization Appliances]: ... and segments the data center networking market into ... of revenues. The report also identifies the factors ... opportunities impacting it along with the future roadmaps. ...
(Date:10/25/2014)... The report “Adipic Acid Market ... - Global Trends & Forecast to 2019” report ... market drivers, opportunities, and trends in different regions. ... figures spread through 217 slides and in-depth TOC ... Forecast to 2019”., http://www.marketsandmarkets.com/Market-Reports/adipic-acid-269.html , Early buyers ...
Breaking Biology Technology:Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 2Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 3Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 4
... Kristina Lind and Mikael Kubista, TATAA Biocenter, Medicinaregatan 7A/B,405 30 Gteborg, Sweden , ... Introduction , A technique for ... Sano et al. (1992). It combines the molecular recognition of antibodies , ... similar , to conventional enzyme-linked immunosorbent assays (ELISA) ...
... Difference gel electrophoresis (DIGE) is a relatively straightforward , ... using fluorescent , dyes. The technique, originally ... cyanine (Cy) dyes to differentially label proteins separated by 2-D gel , ... can be achieved by scanning the multiplex ...
... Joella Blas, and Efthalia Gerasimopoulos, Bio-Rad Laboratories, Inc.,Hercules, CA 94547 USA , ... Introduction , Bio-Plex assays allow ... volume of sample. The assays are based on detection of signal from ... have bound to each target protein. , ...
Cached Biology Technology:Real-Time Immuno-PCR on the iCycler iQ System, Rev A 2Real-Time Immuno-PCR on the iCycler iQ System, Rev A 3Real-Time Immuno-PCR on the iCycler iQ System, Rev A 4Real-Time Immuno-PCR on the iCycler iQ System, Rev A 5Imaging and Analysis of DIGE Product Information Sheet, Rev B 2Imaging and Analysis of DIGE Product Information Sheet, Rev B 3Imaging and Analysis of DIGE Product Information Sheet, Rev B 4Imaging and Analysis of DIGE Product Information Sheet, Rev B 5Imaging and Analysis of DIGE Product Information Sheet, Rev B 6Imaging and Analysis of DIGE Product Information Sheet, Rev B 7Feasibility of Multiplexing Bio-Plex Total Target and Phosphoprotein Assays 2Feasibility of Multiplexing Bio-Plex Total Target and Phosphoprotein Assays 3Feasibility of Multiplexing Bio-Plex Total Target and Phosphoprotein Assays 4
AC input: 50-60 Hz 115-120 V...
MAb to Myoglobin Cardiac...
... workstation is the simplest, easiest-to-use system ever ... liquid handling capabilities,into their labs, or groups ... routine applications on a separate instrument. Plate-handling ... even when you have thousands of ...
... against a large variety of antigens. ... provided with personalized project proposals and ... by Covance remain exclusive property of ... project has four phases: immunization, fusion, ...
Biology Products: