Navigation Links
Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections
Date:10/27/2008

id, both administered intravenously twice daily and analyzed based on populations, including intent-to-treat (ITT), modified intent-to-treat (MITT), per protocol (PP) and modified clinical evaluable (MCE).
  • The ITT population included all patients who received at least one dose of medication;
  • The MITT population included all patients in the ITT population who had an infecting Gram-positive pathogen isolated at baseline;
  • The PP population excludes all patients with any protocol violation; and
  • The MCE population was the same as the PP population, but adding back clinically evaluable patients whose protocol violation was use of additional systemic or topical prohibited antibiotics or high-dose steroids registered as clinical failures.

The causative pathogen distribution in the study population was well-balanced between treatment groups with Staphylococcus aureus (S. aureus) as the predominant pathogen isolated at baseline (76.5 percent for iclaprim and 81.1 percent for linezolid), of which 40 percent of isolates were MRSA.

Patients were evaluated daily for the first four days and then every other day thereafter during the treatment period, at the end of therapy, at the test-of-cure (TOC) visit (7 to 14 days post treatment) and at a late follow-up visit 7 to14 days after the TOC visit. The primary endpoint was the comparative clinical cure rates of iclaprim and linezolid at the TOC visit in the ITT and PP populations.

The most commonly reported adverse events in the clinical studies were: gastrointestinal disorders (7.4 percent versus 10.4 percent for iclaprim and linezolid, respectively); general disorders and administration site conditions (4.2 percent versus 3.9 percent); nervous system disorders (4.8 percent versus 6.5 percent); and skin and subcutaneous tissue disorders (4.2 percent versus 4.5 percent).


'/>"/>

Contact: Dr. Jrgen Raths
41-614-179-660
Zeno Group
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet
2. Improved foam for varicose veins found to be safe in preliminary results from phase II trial
3. Moms obesity during conception phase may set the stage for offsprings obesity risk
4. Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth
5. HGS announces positive Phase 2 LymphoStat-B at ACR meeting
6. Phase 2 of Singapores Biomedical Sciences Initiative gains momentum for clinical research
7. CABI helps phase out dangerous pesticide in EU
8. SinuNase Phase 3 show almost 100 percent of chronic sinusitis cases are from fungal-induced inflamma
9. New test promises quicker, more accurate evaluation for cystic fibrosis patients
10. How eating fruit and vegetables can improve cancer patients response to chemotherapy
11. UCSF Fresno leading-edge study lends hope to emphysema patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Research Hospital study found that 73 percent of adult ... of developing metabolic syndrome and related health problems by ... in the current issue of the journal Cancer ... survivors of childhood cancer in the study had metabolic ... high blood pressure, abdominal obesity, elevated triglyceride and other ...
(Date:7/28/2014)... Brain & Behavior Research Foundation today announced the ... recognizing exceptional clinical and basic research by young ... Investigator Grants. The grants enable early career scientists ... research for the prevention, early detection, treatment, and ... four people. , Six young scientistswinners of the ...
(Date:7/28/2014)... Research and Markets has announced ... America 2014-2018" report to their offering. ... and analyze biological data. These systems capture biological traits ... patterns, and hand measurements from the subject and compare ... main purpose of a biometrics system is to identify ...
Breaking Biology News(10 mins):Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 2Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 3The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 2The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 3The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 4Biometrics Market in Latin America 2014-2018 2
... PLoS ONE highlights how the exploration of the ... of a voyage of discovery, starting with marine animals ... their application as marker in living cells. Many ... fluorescent proteins, which come in a variety of dazzling ...
... 30 Orchid Cellmark Inc.,(Nasdaq: ORCH ), a leading ... for the third quarter of 2008. , ... of 2008 compared,to $15.6 million for the third quarter of 2007. ... compared to a year ago was largely due,to lower revenues in ...
... 10 prominent scientists says that the level of globe-warming carbon ... where world climate will change disastrously unless the level can ... from recent estimates that truly dangerous levels would be reached ... the current edition of the Open Atmospheric Science Journal ...
Cached Biology News:Biomedical research profits from the exploration of the deep sea 2Orchid Cellmark Reports Third Quarter 2008 Financial Results 2Orchid Cellmark Reports Third Quarter 2008 Financial Results 3Orchid Cellmark Reports Third Quarter 2008 Financial Results 4Orchid Cellmark Reports Third Quarter 2008 Financial Results 5Orchid Cellmark Reports Third Quarter 2008 Financial Results 6Orchid Cellmark Reports Third Quarter 2008 Financial Results 7Orchid Cellmark Reports Third Quarter 2008 Financial Results 8Carbon dioxide already in danger zone, warns study 2
(Date:7/28/2014)... MO (PRWEB) July 28, 2014 ... and services that bring the power of genomics to ... inaugural Appistry Pipeline Challenge . , Two ... president of the National Center for Genome Resources, and ... Hospitals and Clinics of Kansas City. Rounding out the ...
(Date:7/28/2014)... , July 28, 2014  InterMune, Inc. (NASDAQ: ... its second quarter 2014 financial results at the close ... live conference call and webcast will be hosted by ... Interested investors and others may participate in ... 212-231-2900 (international), conference ID#21728775. A replay of the webcast and ...
(Date:7/28/2014)... July 28, 2014 The National Model ... Muncie IN, is pleased to announce that it has ... Museum of the United States Air Force. , The ... process that concluded this spring with an on-site inspection ... OH museum. , The National Museum of the ...
(Date:7/25/2014)... Amgen (NASDAQ: AMGN ) announced ... per share dividend for the third quarter of 2014. ... to all stockholders of record as of the close ... About Amgen Amgen is committed to unlocking the potential ... discovering, developing, manufacturing and delivering innovative human therapeutics. This ...
Breaking Biology Technology:Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2InterMune to Release Second Quarter Financial Results on August 6 2AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3
... approved a $500,000 start-up grant for the recently ... for classified, defense-related projects. , ,The consortium, ... initially include the UW System, the Medical College ... the Milwaukee School of Engineering. , ,The consortium ...
... Cisco Systems has reached an agreement ... local area network. , ,The UW-Madison campus serves 41,500 ... includes more than 180 buildings spread across 933 acres. ... can access a personalized window of their financial records, ...
... tiny man with giant ideas. Ill never forget the one and ... a conference of business executives in Cambridge, Massachusetts. There were one ... for a keynote, Drucker spoke immediately after lunch. He had to ... effortlessly for almost two hours. No Powerpoint. No props. No nonsense. ...
Cached Biology Technology:Wisconsin consortium aims for defense business 2Praise for the principles of Peter 2Praise for the principles of Peter 3Praise for the principles of Peter 4
...
The large Dodeca stainer shaking rack holds the staining trays in the large Dodeca stainer....
... in this set of Antibody Microarray ... for a total of over 2100 ... internal control. Antibodies belonging to many ... cell cycle progression, signal transduction and ...
... is the most advanced thermal cycler ever ... performance, the Dyad also boasts graphical programming ... navigation via touch pad or mouse. ... economically expanded to a four-bay system with ...
Biology Products: