Navigation Links
Pharmaceutical breakthrough may make a range of drugs cheaper and more available
Date:1/30/2008

A new study published in the February 2008 print edition of The FASEB Journal (www.fasebj.org) describes a scientific advance that should reduce the cost and increase the availability of a wide range of drugs. In the report, University of Pennsylvania researchers describe how they used gene therapy to reduce the time it takes to breed large animals capable of producing therapeutic proteins in their milk, such as insulin or those that fight cancer. This represents a significant milestone in drug development, as current methods involve cloning, which takes more time and generally costs more.

Having an easier way to harness natures power to produce large quantities of specific proteins in milk could increase the availability of drugs for people who could otherwise not afford these treatments, said Ina Dobrinski, one of the researchers on the study.

The study also is significant because it may also be a new way to eliminate diseases in future generations of animals, such as those used for livestock. Heres why: To get the goats to produce specific proteins, the researchers used radiation to kill a portion of a male goats germ cells (the cells that produce sperm). Then they used a modified adeno-associated virus (a well studied and tolerated gene therapy vector) to insert a gene in the remaining cells. Once the new gene took hold in the germ cells, a predictable number of female offspring produced the desired protein in their milk. The advance is immediately valuable for pharmaceutical development and biology research, but a similar approach could be used to bolster the food supply by eliminating genetic disorders in animals over several generations. It is also possible that once perfected, this technique could eliminate disease genes in humans over several generations, assuming ethical concerns can be resolved adequately.

For thousands of years, people have domesticated cows and goats to make milk, butter and cheese. And for thousands of years dairy products have been used as folk remedies for practically every human illness. Most have been completely ineffective. said Gerald Weissmann, MD, editor-in-chief of The FASEB Journal. So it is reassuring that modern science would find a way to use the milk we drink to yield of drugs that actually work.


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Singulex Teams With Wyeth Pharmaceuticals to Translate Pre-Clinical Biomarker Research Into Clinical Study Design
2. NMR researchers unlock hydrogens secrets to spot polymorphism in pharmaceuticals
3. Biopharmaceutical infrastructure key to lower drug development costs
4. Researchers develop liquid crystal pharmaceuticals to fight cancer and other diseases
5. Bacteria from sponges make new pharmaceuticals
6. Breakthrough research turns the tide on water-borne pathogen
7. Further breakthroughs for breast cancer patients
8. University of Alberta researchers report breakthrough in lowering bad cholesterol, fatty acid levels
9. Genetic breakthrough offers promise in tackling kidney tumors
10. Medical breakthrough for organ transplants and cardiovascular diseases by Flemish researchers
11. Breakthrough technology observes synapse in real time, supporting theory of vesicular recycling
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... -- Research and Markets has announced the addition of ... - Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle ... around 15.1% over the next decade to reach approximately $1,580 million ... estimates and forecasts for all the given segments on global as ...
(Date:3/22/2017)... 21, 2017 Vigilant Solutions , a ... enforcement agencies, announced today the appointment of retired FBI ... public safety business development. Mr. Sheridan brings ... including a focus on the aviation transportation sector, to ... position, Mr. Sheridan served as the Aviation Liaison Agent ...
(Date:3/9/2017)... , Australia , March 9, ... study data at the prestigious World Lung Imaging Workshop ... Andreas Fouras , was invited to deliver the ... pulmonary medicine. This globally recognised event brings together leaders ... share the latest developments in lung imaging. ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... April 21, 2017 , ... The AMA is happy ... school graduates from across the nation. The scholarships are created through funds donated by ... , Scholarship criteria are set by the AMA Scholarship Committee, which is made up ...
(Date:4/21/2017)... ... April 21, 2017 , ... Frederick ... a range of emerging technology-based businesses, recently earned a $77,518 grant from the ... , Founded in 2004, FITCI is Frederick’s first incubator. A non-profit corporation, FITCI ...
(Date:4/20/2017)... TX; Ultrecht, Netherlands (PRWEB) , ... April 20, ... ... Qafis Biometrics Technology today announced their strategic partnership to offer a full ... digital identity authentication, a comprehensive suite of biometric products and the ground-breaking proactive ...
(Date:4/20/2017)... ... ... USDM Life Sciences , the leading risk management, technological innovation and ... announce Holger Braemer as Vice President of its Europe division and Managing ... , Braemer is an integral part of USDM’s expansion of services and solutions for ...
Breaking Biology Technology: