Navigation Links
Petascale computational tools could revolutionize understanding of genomic evolution
Date:11/17/2009

Technological advances in DNA sequencing make determining how living things are related possible by analyzing the ways in which their genes have been rearranged on chromosomes. However, inferring these evolutionary relationships from rearrangement events requires massive computing impossible even on the most advanced computing systems available today.

A four-year $1 million project, funded by the National Science Foundation's PetaApps program, aims to develop computational tools that will use next-generation petascale computers to understand genomic evolution. A team of universities received the grant, including the Georgia Institute of Technology, the University of South Carolina and Penn State. The funding is part of the American Recovery and Reinvestment Act.

"Genome sequences are now available for many organisms, but making biological sense of the genomic data requires high-performance computing methods and an evolutionary perspective, whether you are trying to understand how genes of new functions arise, why genes are organized as they are in chromosomes, or why these arrangements are subject to change," said lead investigator David A. Bader, professor, Computational Science and Engineering Division, Georgia Tech's College of Computing.

Even on today's fastest parallel computers, it could take centuries to analyze genome rearrangements for large, complex organisms. So, the research team -- which also includes Jijun Tang, associate professor, department of computer science and engineering, University of South Carolina, and Stephen Schaeffer, associate professor of biology, Penn State -- is focusing on future generations of petascale machines, which will be able to process more than a thousand trillion calculations per second. Today, most personal computers can only process a few hundred thousand calculations per second.

The researchers plan to develop new algorithms in an open-source software framework that will use the capabilities of parallel, petascale computing platforms to infer ancestral rearrangement events. The starting point to develop these new algorithms will be GRAPPA, an open-source code co-developed by Bader and initially released in 2000 that reconstructed the evolutionary relatedness among species.

The researchers will test the performance of their new algorithms by analyzing a collection of fruit fly genomes.

"Fruit flies -- formally known as Drosophila -- are an excellent model system for studying genome rearrangement because the genome sizes are relatively small for animals, the mechanism that alters gene order is reasonably well understood and the evolutionary relationships among the 12 sequenced genomes are known," said Schaeffer.

The analysis of genome rearrangements in Drosophila will provide a relatively simple system to understand the mechanisms that underlie gene order diversity, which can later be extended to more complex mammalian genomes, such as primates.


'/>"/>

Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Related biology news :

1. Petascale computing tools could provide deeper insight into genomic evolution
2. Petascale climate modeling heats up at University of Miami
3. Symposium marks 20th anniversary of Theoretical and Computational Biophysics Group
4. 7th annual [BC]2 Basel Computational Biology Conference Molecular Evolution June 18-19, 2009
5. Computational model examines the pathways of Alzheimers that strikes at the young
6. Computational model examines the pathways of Alzheimers that strikes at the young
7. 7th [BC]2 Basel Computational Biology Conference
8. Oxford Journals and the International Society for Computational Biology announce new partnership
9. New computational technique allows comparison of whole genomes as easily as whole books
10. Supercomputer provides massive computational boost to biomedical research at TGen
11. Penn presents inaugural symposium on applied mathematics and computational science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/9/2016)... May 9, 2016 Elevay is ... to expanding freedom for high net worth professionals seeking ... today,s globally connected world, there is still no substitute ... ever duplicate sealing your deal with a firm handshake. ... by taking advantage of citizenship via investment programs like ...
(Date:4/26/2016)... LONDON , April 26, 2016 /PRNewswire/ ... Systems, a product subsidiary of Infosys (NYSE: ... partnership to integrate the Onegini mobile security platform ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration ... security to access and transact across channels. Using ...
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... -- The Biodesign Challenge (BDC), a university competition that asks ... systems and biotechnology, announced its winning teams at the ... York City . The teams, chosen ... MoMA,s Celeste Bartos Theater during the daylong summit. Keynote ... of architecture and design, and Suzanne Lee , ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. Hays ... DNA as a Field Application Specialist. , “I am thrilled that Dr. Young ... DNA. “In further expanding our capacity as a scientific integrator, Hays brings a wealth ...
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
Breaking Biology Technology: